Search Results - "R. Pettit, George"

Microplate Alamar Blue Assay for Staphylococcus epidermidis Biofilm Susceptibility Testing by PETTIT, Robin K, WEBER, Christine A, KEAN, Melissa J, HOFFMANN, Holger, PETTIT, George R, RUI TAN, FRANKS, Kelly S, HORTON, Marilyn L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Application of a high throughput Alamar blue biofilm susceptibility assay to Staphylococcus aureus biofilms by Pettit, Robin K, Weber, Christine A, Pettit, George R

“…Staphylococcus aureus and S. epidermidis biofilms differ in structure, growth and regulation, and thus the high-throughput method of evaluating biofilm…”
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Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea by Pettit, G.R, Numata, A, Iwamoto, C, Usami, Y, Yamada, T, Ohishi, H, Cragg, G.M

“…Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel,…”
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Antineoplastic Agents. 599. Total Synthesis of Dolastatin 16 by Pettit, George R, Smith, Thomas H, Arce, Pablo M, Flahive, Erik J, Anderson, Collin R, Chapuis, Jean-Charles, Xu, Jun-Ping, Groy, Thomas L, Belcher, Paul E, Macdonald, Christian B

“…The first 23-step total synthesis of the cyclodepsipeptide dolastatin 16 (1) has been achieved. Synthesis of the dolaphenvaline and dolamethylleuine amino acid…”
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Isolation and Structures of Axistatins 1–3 from the Republic of Palau Marine Sponge Agelas axifera Hentschel by Pettit, George R, Tang, Yuping, Zhang, Qingwen, Bourne, Gregory T, Arm, Christoph A, Leet, John E, Knight, John C, Pettit, Robin K, Chapuis, Jean-Charles, Doubek, Dennis L, Ward, Franklin J, Weber, Christine, Hooper, John N. A

“…An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents…”
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Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin by Dabydeen, Donnette A, Burnett, James C, Bai, Ruoli, Verdier-Pinard, Pascal, Hickford, Sarah J H, Pettit, George R, Blunt, John W, Munro, Murray H G, Gussio, Rick, Hamel, Ernest

“…The complex marine natural product halichondrin B was compared with NSC 707389 (E7389), a structurally simplified, synthetic macrocyclic ketone analog, which…”
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The Marine Product Cephalostatin 1 Activates an Endoplasmic Reticulum Stress-specific and Apoptosome-independent Apoptotic Signaling Pathway by López-Antón, Nancy, Rudy, Anita, Barth, Nicole, Schmitz, Lienhard M., Pettit, George R., Schulze-Osthoff, Klaus, Dirsch, Verena M., Vollmar, Angelika M.

“…Cephalostatin 1, a bis-steroidal marine natural product, has been reported to induce apoptosis without the requirement of an active caspase-8 or mitochondrial…”
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Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa by PETTIT, George R., XU, Jun-Ping, CHAPUIS, Jean-Charles, PETTIT, Robin K., TACKETT, Larry P., DOUBEK, Dennis L., HOOPER, John N. A., SCHMIDT, Jean M.

“…The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to <0.0001 microg/mL) murine and human cancer cell growth…”
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The Cephalostatins. 22. Synthesis of Bis-steroidal Pyrazine Pyrones by Pettit, George R, Moser, Bryan R, Mendonça, Ricardo F, Knight, John C, Hogan, Fiona

“…Cephalostatin 1 (1), a remarkably strong cancer cell growth inhibitory trisdecacyclic, bis-steroidal pyrazine isolated from the marine tube worm Cephalodiscus…”
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The Cephalostatins. 21. Synthesis of Bis-steroidal Pyrazine Rhamnosides by Pettit, George R, Mendonça, Ricardo F, Knight, John C, Pettit, Robin K

“…The synthesis of bis-steroidal pyrazines derived from 3-oxo-11,21-dihydroxypregna-4,17(20)-diene (4) and glycosylation of a D-ring side chain with α-l-rhamnose…”
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Antineoplastic Agents. 465. Structural Modification of Resveratrol:  Sodium Resverastatin Phosphate by Pettit, George R, Grealish, Matthew P, Jung, M. Katherine, Hamel, Ernest, Pettit, Robin K, Chapuis, J.-Charles, Schmidt, Jean M

“…As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4…”
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Corrigendum to “The interaction of spongistatin 1 with tubulin” [Arch. Biochem. Biophys. 727 (2022) 109296 (7 pages)] by Bai, Ruoli, Smith, Amos B., Pettit, George R., Hamel, Ernest

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Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity by Bai, Ruoli, Edler, Michael C, Bonate, Peter L, Copeland, Terry D, Pettit, George R, Ludueña, Richard F, Hamel, Ernest

“…Tasidotin, an oncolytic drug in phase II clinical trials, is a peptide analog of the antimitotic depsipeptide dolastatin 15. In tasidotin, the…”
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Antineoplastic Agents. 556. Isolation and Structure of Coprinastatin 1 from Coprinus cinereus by Pettit, George R, Meng, Yanhui, Pettit, Robin K, Herald, Delbert L, Cichacz, Zbigniew A, Doubek, Dennis L, Richert, Linda

“…Cancer cell line bioassay-guided separation of an ethyl acetate extract prepared from a plant-associated fungus, Coprinus cinereus, led to the isolation of…”
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Synthesis and biological activity of some structural modifications of pancratistatin by Rinner, Uwe, Hillebrenner, Heather L., Adams, David R., Hudlicky, Tomas, Pettit, George R.

“…Graphic Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies…”
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The interaction of spongistatin 1 with tubulin by Bai, Ruoli, Smith, Amos B., Pettit, George R., Hamel, Ernest

“…A tritiated derivative of the sponge-derived natural product spongistatin 1 was prepared, and its interactions with tubulin were examined. [3H]Spongistatin 1…”
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Interaction of diazonamide A with tubulin by Bai, Ruoli, Cruz-Monserrate, Zobeida, Fenical, William, Pettit, George R., Hamel, Ernest

“…[3H]Diazonamide A ([3H]DZA), prepared from the natural product isolated from Diazona angulata, bound to tubulin in larger aberrant assembly products (>500 kDa…”
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QSAR Evaluation of the Ch'an Su and Related Bufadienolides against the Colchicine-Resistant Primary Liver Carcinoma Cell Line PLC/PRF/5 by Kamano, Yoshiaki, Yamashita, Ayano, Nogawa, Toshihiko, Morita, Hiroshi, Takeya, Koichi, Itokawa, Hideji, Segawa, Toshiaki, Yukita, Ayako, Saito, Kyoko, Katsuyama, Mariko, Pettit, George R

“…QSAR analysis has been used to identify the essential structural requirements for increasing the inhibitory activities of selected bufadienolides from the…”
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Antineoplastic Agents. 607. Emetine Auristatins by Pettit, George R, Melody, Noeleen, Chapuis, Jean-Charles

“…The remarkable biological activity of the dolastatin 10 structural modifications quinstatins and isoquinstatins prompted further investigation into drug…”
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Antineoplastic Agents. 527. Synthesis of 7-Deoxynarcistatin, 7-Deoxy-trans-dihydronarcistatin, and trans-Dihydronarcistatin 1 by Pettit, George R, Melody, Noeleen

“…The synthesis of sodium narcistatin (8) was improved (88% overall yield) and the modified reaction sequence was utilized to synthesize three new 3,4-cyclic…”
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