Search Results - "R. Lowenstein, Pedro"

Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy by Gregory, Jason V., Kadiyala, Padma, Doherty, Robert, Cadena, Melissa, Habeel, Samer, Ruoslahti, Erkki, Lowenstein, Pedro R., Castro, Maria G., Lahann, Joerg

“…Glioblastoma (GBM), the most aggressive form of brain cancer, has witnessed very little clinical progress over the last decades, in part, due to the absence of…”
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High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme by Kadiyala, Padma, Li, Dan, Nuñez, Fernando M, Altshuler, David, Doherty, Robert, Kuai, Rui, Yu, Minzhi, Kamran, Neha, Edwards, Marta, Moon, James J, Lowenstein, Pedro R, Castro, Maria G, Schwendeman, Anna

“…Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no cure. Treatment effectiveness for GBM has been limited due to tumor…”
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Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas by Scheetz, Lindsay, Kadiyala, Padma, Sun, Xiaoqi, Son, Sejin, Hassani Najafabadi, Alireza, Aikins, Marisa, Lowenstein, Pedro R, Schwendeman, Anna, Castro, Maria G, Moon, James J

“…Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide…”
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Self-organization in brain tumors: How cell morphology and cell density influence glioma pattern formation by Jamous, Sara, Comba, Andrea, Lowenstein, Pedro R, Motsch, Sebastien

“…Modeling cancer cells is essential to better understand the dynamic nature of brain tumors and glioma cells, including their invasion of normal brain. Our goal…”
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Impact of epigenetic reprogramming on antitumor immune responses in glioma by McClellan, Brandon L, Haase, Santiago, Nunez, Felipe J, Alghamri, Mahmoud S, Dabaja, Ali A, Lowenstein, Pedro R, Castro, Maria G

“…Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a key mediator of glioma progression. Epigenetic dysregulation…”
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ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma by Koschmann, Carl, Calinescu, Anda-Alexandra, Nunez, Felipe J, Mackay, Alan, Fazal-Salom, Janet, Thomas, Daniel, Mendez, Flor, Kamran, Neha, Dzaman, Marta, Mulpuri, Lakshman, Krasinkiewicz, Johnathon, Doherty, Robert, Lemons, Rosemary, Brosnan-Cashman, Jacqueline A, Li, Youping, Roh, Soyeon, Zhao, Lili, Appelman, Henry, Ferguson, David, Gorbunova, Vera, Meeker, Alan, Jones, Chris, Lowenstein, Pedro R, Castro, Maria G

“…Recent work in human glioblastoma (GBM) has documented recurrent mutations in the histone chaperone protein ATRX. We developed an animal model of…”
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The self-organized structure of glioma oncostreams and the disruptive role of passive cells by Barberis, Lucas, Condat, Carlos A., Faisal, Syed M., Lowenstein, Pedro R.

“…Oncostreams are self-organized structures formed by spindle-like, elongated, self-propelled cells recently described in glioblastomas and especially in…”
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Mutant ATRX: uncovering a new therapeutic target for glioma by Haase, Santiago, Garcia-Fabiani, María Belén, Carney, Stephen, Altshuler, David, Núñez, Felipe J, Méndez, Flor M, Núñez, Fernando, Lowenstein, Pedro R, Castro, Maria G

“…ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ATRX mutations are widely distributed in glioma, and…”
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Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression by Comba, Andrea, Faisal, Syed M., Dunn, Patrick J., Argento, Anna E., Hollon, Todd C., Al-Holou, Wajd N., Varela, Maria Luisa, Zamler, Daniel B., Quass, Gunnar L., Apostolides, Pierre F., Abel, Clifford, Brown, Christine E., Kish, Phillip E., Kahana, Alon, Kleer, Celina G., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

“…Intra-tumoral heterogeneity is a hallmark of glioblastoma that challenges treatment efficacy. However, the mechanisms that set up tumor heterogeneity and tumor…”
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Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy by Baker, Gregory J, Yadav, Viveka Nand, Motsch, Sebastien, Koschmann, Carl, Calinescu, Anda-Alexandra, Mineharu, Yohei, Camelo-Piragua, Sandra Ines, Orringer, Daniel, Bannykh, Serguei, Nichols, Wesley S, deCarvalho, Ana C, Mikkelsen, Tom, Castro, Maria G, Lowenstein, Pedro R

“…Abstract As glioma cells infiltrate the brain they become associated with various microanatomic brain structures such as blood vessels, white matter tracts,…”
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Current Approaches for Glioma Gene Therapy and Virotherapy by Banerjee, Kaushik, Núñez, Felipe J, Haase, Santiago, McClellan, Brandon L, Faisal, Syed M, Carney, Stephen V, Yu, Jin, Alghamri, Mahmoud S, Asad, Antonela S, Candia, Alejandro J Nicola, Varela, Maria Luisa, Candolfi, Marianela, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult population and it carries a dismal prognosis. Inefficient drug delivery…”
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Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity by Baker, Gregory J, Chockley, Peter, Yadav, Viveka Nand, Doherty, Robert, Ritt, Michael, Sivaramakrishnan, Sivaraj, Castro, Maria G, Lowenstein, Pedro R

“…Natural killer (NK) cells safeguard against early tumor formation by destroying transformed target cells in a process referred to as NK immune surveillance…”
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Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments by Alghamri, Mahmoud S., McClellan, Brandon L., Hartlage, Carson S., Haase, Santiago, Faisal, Syed Mohd, Thalla, Rohit, Dabaja, Ali, Banerjee, Kaushik, Carney, Stephen V., Mujeeb, Anzar A., Olin, Michael R., Moon, James J., Schwendeman, Anna, Lowenstein, Pedro R., Castro, Maria G.

“…Gliomas are one of the most lethal types of cancers accounting for ∼80% of all central nervous system (CNS) primary malignancies. Among gliomas, glioblastomas…”
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P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells by Muthukrishnan, Sree Deepthi, Kawaguchi, Riki, Nair, Pooja, Prasad, Rachna, Qin, Yue, Johnson, Maverick, Wang, Qing, VanderVeer-Harris, Nathan, Pham, Amy, Alvarado, Alvaro G., Condro, Michael C., Gao, Fuying, Gau, Raymond, Castro, Maria G., Lowenstein, Pedro R., Deb, Arjun, Hinman, Jason D., Pajonk, Frank, Burns, Terry C., Goldman, Steven A., Geschwind, Daniel H., Kornblum, Harley I.

“…Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms…”
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Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications by Comba, Andrea, Faisal, Syed M., Varela, Maria Luisa, Hollon, Todd, Al-Holou, Wajd N., Umemura, Yoshie, Nunez, Felipe J., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

“…Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous system. Rapid tumor growth and diffuse infiltration into healthy brain…”
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Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier by Castro, Maria G, Baker, Gregory J, Lowenstein, Pedro R

“…Immunosuppressive checkpoints mediated by IDO, CTLA4, and PD1/PDL1 play a critical role in glioma progression and the efficacy of immunotherapies. Combined…”
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The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications by Faisal, Syed M., Comba, Andrea, Varela, Maria L., Argento, Anna E., Brumley, Emily, Abel, Clifford, Castro, Maria G., Lowenstein, Pedro R.

“…Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a poor prognosis due to its universal recurrence rate. GBM cells…”
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HMGB1 mediates endogenous TLR2 activation and brain tumor regression by Curtin, James F, Liu, Naiyou, Candolfi, Marianela, Xiong, Weidong, Assi, Hikmat, Yagiz, Kader, Edwards, Matthew R, Michelsen, Kathrin S, Kroeger, Kurt M, Liu, Chunyan, Muhammad, A K M Ghulam, Clark, Mary C, Arditi, Moshe, Comin-Anduix, Begonya, Ribas, Antoni, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant…”
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The transformative potential of mRNA vaccines for glioblastoma and human cancer: technological advances and translation to clinical trials by Tapescu, Iulia, Madsen, Peter J, Lowenstein, Pedro R, Castro, Maria G, Bagley, Stephen J, Fan, Yi, Brem, Steven

“…Originally devised for cancer control, mRNA vaccines have risen to the forefront of medicine as effective instruments for control of infectious disease,…”
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Melanoma induced immunosuppression is mediated by hematopoietic dysregulation by Kamran, Neha, Li, Youping, Sierra, Maria, Alghamri, Mahmoud S., Kadiyala, Padma, Appelman, Henry D., Edwards, Marta, Lowenstein, Pedro R., Castro, Maria G.

“…Tumors are associated with expansion of immunosuppressive cells such as tumor associated macrophages (TAMs), regulatory T cells (Tregs) and myeloid derived…”
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