Search Results - "R. Dahl, Alan"
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Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action
Published in Regulatory toxicology and pharmacology (01-07-2008)“…This report provides a summary of deliberations conducted under the charge for members of Module C Panel participating in the Naphthalene State-of-the-Science…”
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A review of whole animal bioassays of the carcinogenic potential of naphthalene
Published in Regulatory toxicology and pharmacology (01-07-2008)“…This report provides a summary of deliberations conducted under the charge for members of Module A participating in the Naphthalene State-of-the-Science…”
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A RAPID COMBUSTION METHOD FOR THE ACCURATE DETERMINATION OF LOW LEVELS OF TRITIUM IN BIOLOGICAL SAMPLES
Published in Toxicology methods (01-01-1998)“…The authors have developed a simple, accurate method to combust low-level, tritium-containing tissue samples by modifying a tube furnace with two combustion…”
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Inhaled Isotretinoin (13-cis Retinoic Acid) Is an Effective Lung Cancer Chemopreventive Agent in A/J Mice at Low doses: A Pilot Study
Published in Clinical cancer research (01-08-2000)“…In previously treated head-and-neck cancer patients, p.o. administered isotretinoin (13- cis retinoic acid) reduced the occurrence of second aerodigestive…”
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HPLC DETERMINATION OF TRITIATED POLYCYCLIC AROMATIC HYDROCARBON METABOLITES IN THE SUBFEMTOMOLE RANGE
Published in Toxicology methods (01-01-1998)“…In experiments to determine the toxicokinetics of polycyclic aromatic hydrocarbons (PAHs) in lungs at environmentally realistic levels, a technique to measure…”
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Metabolism of 1,3-butadiene: species differences
Published in Toxicology (Amsterdam) (28-10-1996)“…Species differences in the metabolism of 1,3-butadiene (BD) have been studied in an effort to explain the major differences observed in the responses of mice,…”
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Topical Delivery of 13-cis-Retinoic Acid by Inhalation Up-Regulates Expression of Rodent Lung but not Liver Retinoic Acid Receptors
Published in Clinical cancer research (01-09-2000)“…Chemopreventive retinoids may be more effective if delivered to the lung epithelium by inhalation. 13- cis -Retinoic acid (13- cis -RA) was comparable to all-…”
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Nasal Cytochrome P450 2A: Identification, Regional Localization, and Metabolic Activity toward Hexamethylphosphoramide, a Known Nasal Carcinogen
Published in Toxicology and applied pharmacology (01-01-1997)“…Two members of the cytochrome P450 2A subfamily, CYP2A10 and 2A11, are abundant nasal enzymes previously characterized in rabbit olfactory microsomes. Rabbit…”
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Comparison of the disposition of butadiene epoxides in Sprague–Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation
Published in Toxicology (Amsterdam) (21-11-1997)“…1,3-Butadiene (BD), a compound used extensively in the rubber industry, is a potent carcinogen in mice and a weak carcinogen in rats in chronic carcinogenicity…”
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Urinary butadiene diepoxide: a potential biomarker of blood diepoxide
Published in Toxicology (Amsterdam) (07-03-2001)“…The carcinogenicity of 1,3-butadiene (BD) varies greatly in the rodent species in which 2-year bioassay studies were completed. This raises the question of…”
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A relevant dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is extensively metabolized and rapidly absorbed in the canine tracheal mucosa
Published in Cancer research (Chicago, Ill.) (01-04-1998)“…Lung cancer is largely a site-of-entry disease caused by inhaled carcinogenic agents, especially tobacco smoke. Two major groups of procarcinogens,…”
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Chemical and biological characterization of volatile components of environmental samples after fractionation by vacuum line cryogenic distillation
Published in Archives of environmental contamination and toxicology (01-05-1985)“…Volatile components from diesel exhaust particles and coal gasifier process gas condensate were vacuum fractionated by cryogenic distillation and identified by…”
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Nasal cavity enzymes involved in xenobiotic metabolism: effects on the toxicity of inhalants
Published in Critical reviews in toxicology (1991)“…A decade ago, the ability of nasal tissues to metabolize inhalants was only dimly suspected. Since then, the metabolic capacities of nasal cavity tissues has…”
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Thermal redistribution of hydrido and phosphino groups in phosphinohydridogermanes
Published in Inorganic chemistry (01-05-1975)Get full text
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Bridged-polycyclic compounds. LXIII. Reductive ring opening of 3,6-dibenzotricyclo[3.3.0.02,8]octadiene
Published in Journal of organic chemistry (01-09-1970)Get full text
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The fate of inhaled octane and the nephrotoxicant, isooctane, in rats
Published in Toxicology and applied pharmacology (01-09-1989)“…To determine if inhaled nephrotoxic branched and nonnephrotoxic straight chain alkanes differ substantially in their biological fate, male F344 rats were…”
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Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene
Published in Toxicology and applied pharmacology (01-08-1989)“…Occupational exposures to 1,3-butadiene or isoprene occur through their use in the manufacture of rubber and other related polymer products. The purpose of…”
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Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds
Published in Biochemical pharmacology (01-03-1985)“…Eighteen methylenedioxyphenyl (MDP) compounds, including some commonly inhaled by people, were tested for the ability to inhibit rabbit nasal microsomal…”
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Lipid-soluble metal compounds in a coal gasifier process stream
Published in Environmental science & technology (01-08-1982)“…Heavy metal concentrations were measured by atomic absorption spectroscopy in the lipid-soluble fractions of tar from the process stream of an experimental…”
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