Search Results - "R. Carding, Simon"

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health by Parker, Aimée, Fonseca, Sonia, Carding, Simon R.

“…The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of bacteria, archaea, viruses, fungi, and protozoa, coexisting in a…”
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Diet, the intestinal microbiota, and immune health in aging by Clements, Sarah J., R. Carding, Simon

“…Many countries are facing aging populations, with those over 65 years of age likely to represent the largest population over the next 10-20 years. Living…”
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Inflammatory bowel disease: cause and immunobiology by Baumgart, Daniel C, Dr, Carding, Simon R, Prof

“…Summary Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this paper, we discuss how environmental factors (eg, geography,…”
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Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body by Stentz, Régis, Carvalho, Ana L, Jones, Emily J, Carding, Simon R

“…As part of their life cycle, Gram-negative bacteria produce and release microvesicles (outer membrane vesicles, OMVs) consisting of spherical protrusions of…”
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Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier by Hoyles, Lesley, Snelling, Tom, Umlai, Umm-Kulthum, Nicholson, Jeremy K, Carding, Simon R, Glen, Robert C, McArthur, Simon

“…Gut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders. Three…”
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Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome? by Newberry, Fiona, Hsieh, Shen-Yuan, Wileman, Tom, Carding, Simon R

“…Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (ME/CFS) is a disabling and debilitating disease of unknown aetiology. It is a heterogeneous…”
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The Uptake, Trafficking, and Biodistribution of Bacteroides thetaiotaomicron Generated Outer Membrane Vesicles by Jones, Emily J, Booth, Catherine, Fonseca, Sonia, Parker, Aimee, Cross, Kathryn, Miquel-Clopés, Ariadna, Hautefort, Isabelle, Mayer, Ulrike, Wileman, Tom, Stentz, Régis, Carding, Simon R

“…Gram-negative bacteria ubiquitously produce and release nano-size, non-replicative outer membrane vesicles (OMVs). In the gastrointestinal (GI-) tract, OMVs…”
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Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain by Parker, Aimée, Romano, Stefano, Ansorge, Rebecca, Aboelnour, Asmaa, Le Gall, Gwenaelle, Savva, George M, Pontifex, Matthew G, Telatin, Andrea, Baker, David, Jones, Emily, Vauzour, David, Rudder, Steven, Blackshaw, L Ashley, Jeffery, Glen, Carding, Simon R

“…Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to…”
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The gut virome: the ‘missing link’ between gut bacteria and host immunity? by Mukhopadhya, Indrani, Segal, Jonathan P., Carding, Simon R., Hart, Ailsa L., Hold, Georgina L.

“…The human gut virome includes a diverse collection of viruses that infect our own cells as well as other commensal organisms, directly impacting on our…”
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The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis by Rai, Shashank, Arasteh, Maryam, Jefferson, Matthew, Pearson, Timothy, Wang, Yingxue, Zhang, Weijiao, Bicsak, Bertalan, Divekar, Devina, Powell, Penny P., Naumann, Ronald, Beraza, Naiara, Carding, Simon R., Florey, Oliver, Mayer, Ulrike, Wileman, Thomas

“…Macroautophagy/autophagy delivers damaged proteins and organelles to lysosomes for degradation, and plays important roles in maintaining tissue homeostasis by…”
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Use of genetically modified bacteria for drug delivery in humans: Revisiting the safety aspect by Wegmann, Udo, Carvalho, Ana Lucia, Stocks, Martin, Carding, Simon R.

“…The use of live, genetically modified bacteria as delivery vehicles for biologics is of considerable interest scientifically and has attracted significant…”
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Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide by Hoyles, Lesley, Pontifex, Matthew G, Rodriguez-Ramiro, Ildefonso, Anis-Alavi, M Areeb, Jelane, Khadija S, Snelling, Tom, Solito, Egle, Fonseca, Sonia, Carvalho, Ana L, Carding, Simon R, Müller, Michael, Glen, Robert C, Vauzour, David, McArthur, Simon

“…Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain…”
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Extracellular vesicles produced by the human gut commensal bacterium Bacteroides thetaiotaomicron elicit anti-inflammatory responses from innate immune cells by Fonseca, Sonia, Carvalho, Ana L, Miquel-Clopés, Ariadna, Jones, Emily J, Juodeikis, Rokas, Stentz, Régis, Carding, Simon R

“…Bacterial extracellular vesicles (BEVs) produced by gut commensal bacteria have been proposed to play an important role in maintaining host homeostasis…”
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Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease by Durant, Lydia, Stentz, Régis, Noble, Alistair, Brooks, Johanne, Gicheva, Nadezhda, Reddi, Durga, O'Connor, Matthew J, Hoyles, Lesley, McCartney, Anne L, Man, Ripple, Pring, E Tobias, Dilke, Stella, Hendy, Philip, Segal, Jonathan P, Lim, Dennis N F, Misra, Ravi, Hart, Ailsa L, Arebi, Naila, Carding, Simon R, Knight, Stella C

“…Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized…”
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Regulation of Enteroendocrine Cell Networks by the Major Human Gut Symbiont Bacteroides thetaiotaomicron by Modasia, Amisha, Parker, Aimee, Jones, Emily, Stentz, Regis, Brion, Arlaine, Goldson, Andrew, Defernez, Marianne, Wileman, Tom, Ashley Blackshaw, L, Carding, Simon R

“…Gut microbes have critical roles in maintaining host physiology, but their effects on epithelial chemosensory enteroendocrine cells (EEC) remain unclear. We…”
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A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut by Stentz, Régis, Osborne, Samantha, Horn, Nikki, Li, Arthur W.H., Hautefort, Isabelle, Bongaerts, Roy, Rouyer, Marine, Bailey, Paul, Shears, Stephen B., Hemmings, Andrew M., Brearley, Charles A., Carding, Simon R.

“…Dietary InsP6 can modulate eukaryotic cell proliferation and has complex nutritive consequences, but its metabolism in the mammalian gastrointestinal tract is…”
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A systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis by Brooks-Warburton, Johanne, Modos, Dezso, Sudhakar, Padhmanand, Madgwick, Matthew, Thomas, John P., Bohar, Balazs, Fazekas, David, Zoufir, Azedine, Kapuy, Orsolya, Szalay-Beko, Mate, Verstockt, Bram, Hall, Lindsay J., Watson, Alastair, Tremelling, Mark, Parkes, Miles, Vermeire, Severine, Bender, Andreas, Carding, Simon R., Korcsmaros, Tamas

“…We describe a precision medicine workflow, the integrated single nucleotide polymorphism network platform (iSNP), designed to determine the mechanisms by which…”
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Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease by Gul, Lejla, Modos, Dezso, Fonseca, Sonia, Madgwick, Matthew, Thomas, John P., Sudhakar, Padhmanand, Booth, Catherine, Stentz, Régis, Carding, Simon R., Korcsmaros, Tamas

“…The gastrointestinal (GI) tract harbours a complex microbial community, which contributes to its homeostasis. A disrupted microbiome can cause GI‐related…”
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A protocol paper for the MOTION Study-A longitudinal study in a cohort aged 60 years and older to obtain mechanistic knowledge of the role of the gut microbiome during normal healthy ageing in order to develop strategies that will improve lifelong health and wellbeing by Phillips, Sarah, Watt, Rachel, Atkinson, Thomas, Rajan, Shelina, Hayhoe, Antonietta, Savva, George M, Hornberger, Michael, Burton, Ben J L, Saada, Janak, Cambell-Kelly, Melissa, Rushbrook, Simon, Carding, Simon R

“…Advances in medicine and public health mean that people are living longer; however, a significant proportion of that increased lifespan is spent in a prolonged…”
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Defining the Bacteroides Ribosomal Binding Site by WEGMANN, Udo, HORN, Nikki, CARDING, Simon R

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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