Search Results - "R. Bain, James"

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street by White, Phillip J., McGarrah, Robert W., Herman, Mark A., Bain, James R., Shah, Svati H., Newgard, Christopher B.

“…A strong association of obesity and insulin resistance with increased circulating levels of branched-chain and aromatic amino acids and decreased glycine…”
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A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels by van Vliet, Stephan, Bain, James R., Muehlbauer, Michael J., Provenza, Frederick D., Kronberg, Scott L., Pieper, Carl F., Huffman, Kim M.

“…A new generation of plant-based meat alternatives—formulated to mimic the taste and nutritional composition of red meat—have attracted considerable consumer…”
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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice by Ridaura, Vanessa K., Faith, Jeremiah J., Rey, Federico E., Cheng, Jiye, Duncan, Alexis E., Kau, Andrew L., Griffin, Nicholas W., Lombard, Vincent, Henrissat, Bernard, Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga, Semenkovich, Clay F., Funai, Katsuhiko, Hayashi, David K., Lyle, Barbara J., Martini, Margaret C., Ursell, Luke K., Clemente, Jose C., Van Treuren, William, Walters, William A., Knight, Rob, Newgard, Christopher B., Heath, Andrew C., Gordon, Jeffrey I.

“…The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for…”
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Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease by Shah, Svati H., MD, MHS, Sun, Jie-Lena, MS, Stevens, Robert D., PhD, Bain, James R., PhD, Muehlbauer, Michael J., PhD, Pieper, Karen S., MS, Haynes, Carol, BS, Hauser, Elizabeth R., PhD, Kraus, William E., MD, Granger, Christopher B., MD, Newgard, Christopher B., PhD, Califf, Robert M., MD, Newby, L. Kristin, MD, MHS

“…Background Cardiovascular risk models remain incomplete. Small-molecule metabolites may reflect underlying disease and, as such, serve as novel biomarkers of…”
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Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation by ENXUAN JING, O'NEILL, Brian T, GIBSON, Bradford W, KAHN, C. Ronald, RARDIN, Matthew J, KLEINRIDDERS, André, ILKEYEVA, Olga R, USSAR, Siegfried, BAIN, James R, LEE, Kevin Y, VERDIN, Eric M, NEWGARD, Christopher B

“…Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression…”
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A Systematic Review on the Use of Fibrin Glue for Peripheral Nerve Repair by Sameem, Mojib, Wood, Thomas J., Bain, James R.

“…Although Tisseel (Baxter, Deerfield, Ill.) was introduced over 30 years ago, the literature remains scant regarding its use and efficacy in peripheral nerve…”
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The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins by McNulty, Nathan P, Yatsunenko, Tanya, Hsiao, Ansel, Faith, Jeremiah J, Muegge, Brian D, Goodman, Andrew L, Henrissat, Bernard, Oozeer, Raish, Cools-Portier, Stéphanie, Gobert, Guillaume, Chervaux, Christian, Knights, Dan, Lozupone, Catherine A, Knight, Rob, Duncan, Alexis E, Bain, James R, Muehlbauer, Michael J, Newgard, Christopher B, Heath, Andrew C, Gordon, Jeffrey I

“…Understanding how the human gut microbiota and host are affected by probiotic bacterial strains requires carefully controlled studies in humans and in mouse…”
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Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis by Kraus, William E, Muoio, Deborah M, Stevens, Robert, Craig, Damian, Bain, James R, Grass, Elizabeth, Haynes, Carol, Kwee, Lydia, Qin, Xuejun, Slentz, Dorothy H, Krupp, Deidre, Muehlbauer, Michael, Hauser, Elizabeth R, Gregory, Simon G, Newgard, Christopher B, Shah, Svati H

“…Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA)…”
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Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss by Laferrère, Blandine, Reilly, David, Arias, Sara, Swerdlow, Nicholas, Gorroochurn, Prakash, Bawa, Baani, Bose, Mousumi, Teixeira, Julio, Stevens, Robert D, Wenner, Brett R, Bain, James R, Muehlbauer, Michael J, Haqq, Andrea, Lien, Lillian, Shah, Svati H, Svetkey, Laura P, Newgard, Christopher B

“…Glycemic control is improved more after gastric bypass surgery (GBP) than after equivalent diet-induced weight loss in patients with morbid obesity and type 2…”
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Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness by Batch, Bryan C, Shah, Svati H, Newgard, Christopher B, Turer, Christy B, Haynes, Carol, Bain, James R, Muehlbauer, Michael, Patel, Mahesh J, Stevens, Robert D, Appel, Lawrence J, Newby, L. Kristin, Svetkey, Laura P

“…Abstract Objective To identify novel biomarkers through metabolomic profiles that distinguish metabolically well (MW) from metabolically unwell (MUW)…”
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Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export by White, Phillip J, Lapworth, Amanda L, An, Jie, Wang, Liping, McGarrah, Robert W, Stevens, Robert D, Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J, Bain, James R, Trimmer, Jeff K, Brosnan, M. Julia, Rolph, Timothy P, Newgard, Christopher B

“…Abstract Objective A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident…”
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Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure by Hunter, Wynn G., Kelly, Jacob P., McGarrah, Robert W., Khouri, Michel G., Craig, Damian, Haynes, Carol, Ilkayeva, Olga, Stevens, Robert D., Bain, James R., Muehlbauer, Michael J., Newgard, Christopher B., Felker, G. Michael, Hernandez, Adrian F., Velazquez, Eric J., Kraus, William E., Shah, Svati H.

“…Background Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly…”
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Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women by Huffman, Kim M, Shah, Svati H, Stevens, Robert D, Bain, James R, Muehlbauer, Michael, Slentz, Cris A, Tanner, Charles J, Kuchibhatla, Maragatha, Houmard, Joseph A, Newgard, Christopher B, Kraus, William E

“…OBJECTIVE: To determine whether circulating metabolic intermediates are related to insulin resistance and β-cell dysfunction in individuals at risk for type 2…”
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Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans by Glynn, Erin L., Piner, Lucy W., Huffman, Kim M., Slentz, Cris A., Elliot-Penry, Lorraine, AbouAssi, Hiba, White, Phillip J., Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga R., Stevens, Robert D., Porter Starr, Kathryn N., Bales, Connie W., Volpi, Elena, Brosnan, M. Julia, Trimmer, Jeff K., Rolph, Timothy P., Newgard, Christopher B., Kraus, William E.

“…Aims/hypotheses Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study…”
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Leptin therapy in insulin-deficient type I diabetes by Wang, May-yun, Chen, Lijun, Clark, Gregory O, Lee, Young, Stevens, Robert D, Ilkayeva, Olga R, Wenner, Brett R, Bain, James R, Charron, Maureen J, Newgard, Christopher B, Unger, Roger H

“…In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic state through…”
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Utilization of the Rat Tibial Nerve Transection Model to Evaluate Cellular and Molecular Mechanisms Underpinning Denervation-Mediated Muscle Injury by Doherty, Christina, Lodyga, Monika, Correa, Judy, Di Ciano-Oliveira, Caterina, Plant, Pamela J, Bain, James R, Batt, Jane

“…Peripheral nerve injury denervates muscle, resulting in muscle paralysis and atrophy. This is reversible if timely muscle reinnervation occurs. With delayed…”
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Correction: Path-level interpretation of Gaussian graphical models using the pair-path subscore by Gill, Nathan P, Balasubramanian, Raji, Bain, James R, Muehlbauer, Michael J, Lowe, William L, Scholtens, Denise M

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Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion by White, Phillip J., Lapworth, Amanda L., McGarrah, Robert W., Kwee, Lydia Coulter, Crown, Scott B., Ilkayeva, Olga, An, Jie, Carson, Matthew W., Christopher, Bridgette A., Ball, James R., Davies, Michael N., Kjalarsdottir, Lilja, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Stevens, Robert D., Koves, Timothy R., Muoio, Deborah M., Brozinick, Joseph T., Gimeno, Ruth E., Brosnan, M. Julia, Rolph, Timothy P., Kraus, William E., Shah, Svati H., Newgard, Christopher B.

“…Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain…”
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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver by Monetti, Mara, Levin, Malin C., Watt, Matthew J., Sajan, Mini P., Marmor, Stephen, Hubbard, Brian K., Stevens, Robert D., Bain, James R., Newgard, Christopher B., Farese, Robert V., Hevener, Andrea L., Farese, Robert V.

“…Hepatic steatosis, the accumulation of lipids in the liver, is widely believed to result in insulin resistance. To test the causal relationship between hepatic…”
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Path-level interpretation of Gaussian graphical models using the pair-path subscore by Gill, Nathan P, Balasubramanian, Raji, Bain, James R, Muehlbauer, Michael J, Lowe, Jr, William L, Scholtens, Denise M

“…BACKGROUND : Construction of networks from cross-sectional biological data is increasingly common. Many recent methods have been based on Gaussian graphical…”
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