Search Results - "R. A. Khamitov"

Optimization of genetic constructs for high-level expression of the darbepoetin gene in mammalian cells by Shukurov, R. R, Kazachenko, K. Yu, Kozlov, D. G, Nurbakov, A. A, Sautkina, E. N, Khamitov, R. A, Seryogin, Yu. A

“…Genetic constructs were designed in order to optimize darbepoetin production in CHO cells. They are characterized by a higher level of structural optimization…”
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Design of a stable cell line producing recombinant darbepoetin alpha based on CHO cells by Shukurov, R. R, Lobanova, N. V, Savinova, I. N, Vorobyova, I. G, Nurbakov, A. A, Ermolina, L. V, Orlova, N. V, Mosina, A. G, Antonova, L. P, Khamitov, R. A, Seryogin, Yu. A

“…A stable cell line that is based on CHO cells and produces 100 mg per liter of culture medium of recombinant darbepoetin alpha with a target glycosylated…”
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A Study of the Comparability of the Pharmacodynamic, Toxicological, and Pharmacokinetic Properties of the Reference Drug Pulmozyme® and the Biosimilar Drug Tigerase by Aksenova, M S, Bocharova, E N, Abbasova, S G, Ponomarev, A S, Loginova, V V, Bolotnikova, M V, Belskaya, N V, Kazarov, A A, Lisova, A E, Kudina, N K, Pantyushenko, M S, Zhilyaeva, M V, Kopein, D S, Karelov, Yu M, Erastov, G G, Lykov, M V, Khamitov, R A

“…The article presents the results of studies of the drug Tigerase® (inhalation solution manufactured by JSC GENERIUM, Russia), conducted to obtain evidence of…”
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Methodological Approaches to Validation of Therapeutic Recombinant Proteins Production Based on the Quality by Design Concept by Stratonova, N. V., Lisov, A. S., Morozov, A. N., Tyupa, D. V., Khamitov, R. A.

“…Validation of production processes based on the Quality by Design (QbD) principles calls for thorough scientific understanding of the processes and enhancement…”
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The current pattern of reconstructive surgery for breast cancer by Ismagilov, A. Kh, Khamitov, A. R., Vanesyan, A. S.

“…In Russia, breast cancer (BC) occupies a leading place in the pattern of cancers, the incidence of which is 20.9 %, among the female population; in 2013 there…”
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Elaboration of an algorithm for preserving a projective skin flap above the tumor when planning subcutaneous mastectomy from an aesthetically acceptable area in patients with breast nodule cancer by Khamitov, A. R., Ismagilov, A. Kh, Sabirov, A. G., Balatenko, N. V., Zagvozkina, D. O., Galeev, M. V., Kiyasov, I. A.

“…Indications for the conservation of the skin flap over the tumor for potential offset of the operational access in aesthetically acceptable zone in patients…”
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Antiviral effectiveness of the combined use of amixine and virasole in experimental hemorrhagic fever with renal syndrome in sucking albino mice by Loginova, S Ia, Koval'chuk, A V, Borisevich, S V, Kopylova, N K, Pashchenko, Iu I, Khamitov, R A, Maksimov, V A, Shuster, A M

“…The antiviral effectiveness of the combined and single use of superlow-dose amixine and virasole on the course of experimental hemorrhagic fever with renal…”
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Analysis of Arbidol® Effectiveness agains an Experimental Form of Severe Acute Respiratory Syndrome by S. Ya. Loginova, V. N. Shchukina, S. V. Borisevich, R. A. Khamitov, V. A. Maksimov, A. M. Shuster

“…Studies have been conducted to assess the effectiveness of Arbidol® in relation to the experimental form of severe acute respiratory syndrome in Syrian Golden…”
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Virus neutralizing antibodies in pseudovirus particle neutralization reaction as a bioanalytical part of a Salnavac® vaccine clinical trial by Zuev, Evgeniy V., Markova, Oksana Anatolievna, Kulemzin, Sergey V., Poteryaev, Dmitry A., Litvinova, Natalya A., Korotkevich, Ilya A., Grigiryeva, Taisiya V., Khamitov, Ravil A.

“…Introduction. The SARS-CoV-2 coronavirus pandemic has been a major challenge for all areas of medical science, causing a surge of new developments in various…”
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Optimization and validation of flow cytometry method for quantification of SARS-CoV-2 antigen-reactive human memory T cells by Strizhakova, Olga M., Pershin, Andrey S., Kazarov, Alexander A., Lyagoskin, Ivan V., Bahareva, Yana A., Vasil'ev, Alexander P., Nikonova, Yulia A., Egorova, Irina Yu, Shukurov, Rahim R., Khamitov, Ravil A.

“…A proper and representative monitoring of SARS-CoV-2 herd immunity including a long-term health impact on recovered patients and vaccinated individuals is of…”
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Plastic surgery for breast cancer: еssentials, classification, performance algorithm by A. Kh. Ismagilov, A. S. Vanesyan, A. R. Khamitov, I. F. Kamaletdinov

“…The choice of plastic surgical techniques for cancer is influenced by two factors: resection volume/baseline breast volume ratio and tumor site.Based on these…”
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Comparative safety evaluation of intranasal and intramuscular immunisation with Ad26 and Ad5-vectored vaccines to prevent coronavirus infection by Zuev, E. V., Evdokimova, O. L., Markova, O. A., Korotkevich, I. A., Grigorieva, T. V., Khamitov, R. A.

“…Scientific relevance. Intranasal vaccination may dramatically change current approaches to mass immunisation against various infections, shifting the focus…”
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An experience of scaling and intensifying the industrial production of the Gam-COVID-Vac vector adenovirus vaccine in the limiting conditions of the pandemic by Morozov, A. N., Yakhin, I. R., Stratonova, N. V., Kutskir, M. V., Poteryaev, D. A., Khamitov, R. A.

“…The COVID-19 pandemic has presented a global challenge to the health system. More than 200 years of world epidemiological experience since the first mass use…”
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Prospects for Using the ELISPOT Technological Platform as Part of Anti-Epidemic Measures Against the New Coronavirus Infection COVID-19 by Poteryaev, D. A., Khamitov, R. A., Efimov, G. A., Shuster, A. M.

“…Determination of T-cell immune response to SARS-CoV-2 is important both for diagnosis of the disease in symptomatic patients, and for determination of the…”
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Validation of a test procedure for determination of specific activity of human recombinant interferon beta (Infibeta®) using various cell/virus combinations by Lebedeva, Yu. N., Litvinova, N. A., Lobanova, T. N., Shukurov, R. R., Khamitov, R. A., Gaiderova, L. A.

“…Interferon beta preparations have demonstrated efficacy in the treatment of multiple sclerosis. One of the most important quality attributes that support…”
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Assessment of T-cell immunity to SARS-CoV-2 in COVID-19 convalescents and vaccinated subjects, using TigraTest® SARS-CoV-2 ELISPOT kit by Poteryaev, D. A., Abbasova, S. G., Ignatyeva, P. E., Strizhakova, O. M., Kolesnik, S. V., Khamitov, R. A.

“…With the onset of the COVID-19 pandemic, a number of molecular-based tests have been developed to diagnose SARS-CoV-2 infection. However, numerous available…”
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The Creation of Technological Lines for the Cultivation of Modified Lines of Mammalian Cells Expressing Recombinant Proteins by I. A. Churkin, S. V. Borisevich, D. A. Kutaev, V. T. Lymar, Yu. I. Pashchenko, E. V. Gordeev, V. S. Kulish, T. M. Plekhanova, R. A. Khamitov, E. N. Sautkina

“…The article presents data for creating technological line for the cultivation of modified lines of mammalian cells expressing recombinant proteins. This line…”
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Optimisation of culture conditions for a producer clone coexpressing arylsulfatase B and a formylglycine-generating enzyme in order to increase the yield of arylsulfatase B by Timonova, S. S., Smolova, K. A., Kirik, I. A., Pantyushenko, M. S., Anisimov, R. L., Khamitov, R. A., Piskunov, A. A., Bade, V. N.

“…Maroteaux—Lamy syndrome (mucopolysaccharidosis type VI) is an orphan genetic disease caused by mutations in the arylsulfatase B gene ( ARSB ), which encodes…”
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Increasing productivity of arylsulfatase B-producing cell line by coexpression of formylglycine-generating enzyme by Timonova, S. S., Smolova, K. A., Zaripova, D. T., Pantyushenko, M. S., Koroleva, M. A., Anisimov, R. L., Khamitov, R. A., Piskunov, A. A., Bade, V. N.

“…Mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome) is an orphan genetic disease caused by deficiency of the lysosomal enzyme arylsulfatase B (ASB). The…”
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Physico-Chemical and Biological Properties of Biosimilar and Reference Tissue Plasminogen Activator Products by Gusarova, V. D., Pantyushenko, M. S., Simonov, V. M., Shukurov, R. R., Khamitov, R. A., Vishnevskiy, A. Yu

“…Recombinant tissue plasminogen activator (international nonproprietary name — alteplase) which was developed by «GENERIUM» (Russia) and received a marketing…”
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