Search Results - "R M Arduini"

High-resolution crystal structures of distal histidine mutants of sperm whale myoglobin by Quillin, M L, Arduini, R M, Olson, J S, Phillips, Jr, G N

“…The highly conserved distal histidine residue (His64) of sperm whale myoglobin modulates the affinity of ligands. In an effort to fully characterize the…”
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N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model by Baker, Darren P, Lin, Edward Y, Lin, Kochung, Pellegrini, Maria, Petter, Russell C, Chen, Ling Ling, Arduini, Robert M, Brickelmaier, Margot, Wen, Dingyi, Hess, Donna M, Chen, Liqing, Grant, Donna, Whitty, Adrian, Gill, Alan, Lindner, Daniel J, Pepinsky, R Blake

“…PEGylation of IFN-alpha has been used successfully to improve the pharmacokinetic properties and efficacy of the drug. To prepare a PEGylated form of human…”
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Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains by Arduini, R M, Strauch, K L, Runkel, L A, Carlson, M M, Hronowski, X, Foley, S F, Young, C N, Cheng, W, Hochman, P S, Baker, D P

“…The extracellular portions of the chains that comprise the human type I interferon receptor, IFNAR1 and IFNAR2, have been expressed and purified as recombinant…”
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Crystal structure of myoglobin from a synthetic gene by Phillips, Jr, G N, Arduini, R M, Springer, B A, Sligar, S G

“…Crystals have been grown of myoglobin produced in Escherichia coli from a synthetic gene, and the structure has been solved to 1.9 A resolution. The space…”
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Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification by Taylor, Frederick R, Wen, Dingyi, Garber, Ellen A, Carmillo, Amie N, Baker, Darren P, Arduini, Robert M, Williams, Kevin P, Weinreb, Paul H, Rayhorn, Paul, Hronowski, Xiaoping, Whitty, Adrian, Day, Eric S, Boriack-Sjodin, Ann, Shapiro, Renee I, Galdes, Alphonse, Pepinsky, R. Blake

“…Post-translational modifications of the developmental signaling protein Sonic hedgehog (Shh) by a long-chain fatty acid at the N-terminus and cholesterol at…”
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A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate by T E Carver, R E Brantley, Jr, E W Singleton, R M Arduini, M L Quillin, G N Phillips, Jr, J S Olson

“…Mutants of sperm whale myoglobin were constructed at position 29 (B10 in helix notation) to examine the effects of distal pocket size on the rates of ligand…”
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Regulation of STAT protein synthesis by c-Cbl by BLESOFSKY, Warren A, MOWEN, Kerri, ARDUINI, Robert M, BAKER, Darren P, MURPHY, Maria A, BOWTELL, David D. L, DAVID, Michael

“…Many cytokines and growth factors induce transcription of immediate early response genes by activating members of the Signal Transducers and Activators of…”
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Cutting edge: role of STAT1, STAT3, and STAT5 in IFN-alpha beta responses in T lymphocytes by Tanabe, Yoshinari, Nishibori, Takeaki, Su, Leon, Arduini, Robert M, Baker, Darren P, David, Michael

“…Engagement of the IFN-alphabeta receptor initiates multiple signaling cascades, including activation of the STAT. In this study, we demonstrate that…”
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Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI) by JUSWINDER SINGH, CHUAQUI, Claudio E, PAPADATOS, James L, BOWES, Scott, JOSIAH, Serene, LING, Leona E, BORIACK-SJODIN, P. Ann, LEE, Wen-Cherng, PONTZ, Timothy, CORBLEY, Michael J, CHEUNG, H.-Kam, ARDUINI, Robert M, MEAD, Jonathan N, NEWMAN, Miki N

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Expression, purification, and characterization of rat interferon-β, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters by Arduini, Robert M, Li, Zhifang, Rapoza, Alan, Gronke, Robert, Hess, Donna M, Wen, Dingyi, Miatkowski, Konrad, Coots, Caroline, Kaffashan, Azita, Viseux, Nelly, Delaney, Jeannine, Domon, Bruno, Young, Carmen N, Boynton, Raymond, Chen, Ling Ling, Chen, Liqing, Betzenhauser, Matthew, Miller, Stephan, Gill, Alan, Pepinsky, R.Blake, Hochman, Paula S, Baker, Darren P

“…To identify potential new clinical uses and routes of administration for human interferon-β-1a (IFN-β-1a), we have developed an expression and purification…”
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A novel site-directed mutant of myoglobin with an unusually high O sub(2) affinity and low autooxidation rate by Carver, TE, Brantley, RE Jr, Singleton, E W, Arduini, R M, Quillin, M L, Phillips, GN Jr, Olson, J S

“…Mutants of sperm whale myoglobin were constructed at position 29 (B10 in helix notation) to examine the effects of distal pocket size on the rates of ligand…”
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A novel site-directed mutant of myoglobin with an unusally high O2 affinity and low autooxidation rate by CARVER, T. E, BRANTLEY, B. E, SINGLETON, E. W, ARDUINI, R. M, QUILLIN, M. L, PHILLIPS, G. N, OLSON, J. S

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