Search Results - "R J Mertz"

Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells by J F Worley, 3rd, M S McIntyre, B Spencer, R J Mertz, M W Roe, I D Dukes

“…Glucose stimulation of islet beta-cell insulin secretion is initiated by membrane depolarization and an elevation in intracellular free calcium concentration…”
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Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans by Roe, M.W, Philipson, L.H, Frangakis, C.J, Kuznetsov, A, Mertz, R.J, Lancaster, M.E, Spencer, B, Worley, J.F. III, Dukes, I.D

“…Non-insulin-dependent diabetes mellitus (NIDDM) is a metabolic disease associated with abnormal insulin secretion, the underlying mechanisms of which are…”
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Dependence on NADH produced during glycolysis for beta-cell glucose signaling by I D Dukes, M S McIntyre, R J Mertz, L H Philipson, M W Roe, B Spencer, J F Worley, 3rd

“…An increase in cytosolic ATP following glucose metabolism by pancreatic beta-cells is the key signal initiating insulin secretion by causing blockade of…”
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Choroidal Retinoic Acid Synthesis: A Possible Mediator between Refractive Error and Compensatory Eye Growth by MERTZ, JAMES R., WALLMAN, JOSH

“…Research over the past two decades has shown that the growth of young eyes is guided by vision. If near-or far-sightedness is artificially imposed by spectacle…”
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Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose by Roe, M.W., Lancaster, M.E., Mertz, R.J., Worley, J.F., Dukes, I.D.

“…Glucose-activated beta-cell insulin secretion depends upon elevation of intracellular calcium concentration, [Ca2+]i, which is thought to arise from Ca2+…”
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Thapsigargin inhibits the glucose-induced decrease of intracellular Ca2+ in mouse islets of Langerhans by Roe, M W, Mertz, R J, Lancaster, M E, Worley, 3rd, J F, Dukes, I D

“…Stimulation of pancreatic islets of Langerhans with glucose results in changes in intracellular Ca2+ concentration ([Ca2+]i). With the use of mouse islets…”
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Regulation of insulin release by factors that also modify glutamate dehydrogenase by Fahien, L A, MacDonald, M J, Kmiotek, E H, Mertz, R J, Fahien, C M

“…Leucine and monomethyl succinate initiate insulin release, and glutamine potentiates leucine-induced insulin release. Alanine enhances and malate inhibits…”
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Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells by Blomhoff, R, Rasmussen, M, Nilsson, A, Norum, K R, Berg, T, Blaner, W S, Kato, M, Mertz, J R, Goodman, D S, Eriksson, U

“…The main retinoids and some binding proteins and enzymes involved in retinol metabolism have been quantified in different types of rat liver cells. Hepatic…”
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Influence of retinoid nutritional status on cellular retinol- and cellular retinoic acid-binding protein concentrations in various rat tissues by Kato, M, Blaner, W S, Mertz, J R, Das, K, Kato, K, Goodman, D S

“…Studies were conducted to explore the effects of differences in retinoid nutritional status and of sex on the tissue distribution and levels of cellular…”
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Insulin-secreting β-cells possess specific receptors for interleukin-1β by Hammonds, Peter, Beggs, Mark, Beresford, Guy, Espinal, Joseph, Clarke, Jennifer, Mertz, Robert J.

“…The effect of the cytokine interleukin-1β on the insulin secretory responsiveness of single β-cells (HIT-T15) was investigated. In the short-term, IL-1β…”
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Potentiation by glucose metabolites of inositol trisphosphate-induced calcium mobilization in permeabilized rat pancreatic islets by Rana, R S, Sekar, M C, Mertz, R J, Hokins, L E, MacDonald, M J

“…Saponin-permeabilized rat pancreatic islets degraded exogenously added inositol 1,4,5-trisphosphate (IP3), and degradation was inhibited in the presence of…”
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Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets by MacDonald, M J, Fahien, L A, Mertz, R J, Rana, R S

“…Esters of carboxylic acids are permeable to cells and once inside the cell are hydrolyzed to carboxylic acids. Methyl and ethyl esters of succinate and other…”
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Absence of effect of culture duration on glucose-activated alterations in intracellular calcium concentration in mouse pancreatic islets by Roe, M W, Spencer, B, Lancaster, M E, Mertz, R J, Worley, 3rd, J F, Dukes, I D

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High activity of mitochondrial glycerol phosphate dehydrogenase in insulinomas and carcinoid and other tumors of the amine precursor uptake decarboxylation system by MACDONALD, M. J, WARNER, T. F, MERTZ, R. J

“…The activity of the mitochondrial glycerol phosphate dehydrogenase (EC 1.1.99.5), the enzyme unique to the glycerol phosphate hydrogen shuttle, was measured in…”
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Evidence for glucose-responsive and -unresponsive pools of phospholipid in pancreatic islets by Rana, R S, Mertz, R J, Kowluru, A, Dixon, J F, Hokin, L E, MacDonald, M J

“…The effect of glucose on the metabolism of phospholipids in pancreatic islets was studied with three radioactive phospholipid precursors, [32P]orthophosphate,…”
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Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling by Roe, M W, Worley, 3rd, J F, Mittal, A A, Kuznetsov, A, DasGupta, S, Mertz, R J, Witherspoon, 3rd, S M, Blair, N, Lancaster, M E, McIntyre, M S, Shehee, W R, Dukes, I D, Philipson, L H

“…Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles…”
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Effects of dietary retinoic acid on cellular retinol- and retinoic acid-binding protein levels in various rat tissues by Blaner, W S, Das, K, Mertz, J R, Das, S R, Goodman, D S

“…A study was conducted to explore the effects of retinoic acid, fed to retinol-deficient rats, on the tissue distribution and levels of cellular retinol-binding…”
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Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis by Mertz, R J, Worley, J F, Spencer, B, Johnson, J H, Dukes, I D

“…The energy requirements of most cells supplied with glucose are fulfilled by glycolytic and oxidative metabolism, yielding ATP. In pancreatic beta-cells, a…”
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Subunit dimers in sheep spleen apoferritin. The effect on iron storage by Mertz, J R, Theil, E C

“…Ferritin with high and low iron content, 2000 and 790 iron atoms/molecule, was isolated from the spleens of copper-poisoned and control lambs, respectively…”
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Glyceraldehyde phosphate: an insulin secretagogue with possible effects on inositol phosphate formation in pancreatic islets by MacDonald, M J, Mertz, R J, Rana, R S

“…The insulinotropic action of glucose, the most potent physiologic insulin secretagogue, involves its metabolism. However, no glucose metabolite has ever been…”
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