Search Results - "R D Vaughan-Jones"

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation by Swietach, P, Hulikova, A, Vaughan-Jones, R D, Harris, A L

“…In this review, we discuss the role of the tumour-associated carbonic anhydrase isoform IX (CAIX) in the context of pH regulation. We summarise recent…”
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Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells by Buckler, K. J., Vaughan‐Jones, R. D.

“…Mitochondrial uncouplers are potent stimulants of the carotid body. We have therefore investigated their effects upon isolated type I cells. Both…”
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Intrinsic H+ ion mobility in the rabbit ventricular myocyte by Vaughan‐Jones, R. D., Peercy, B. E., Spitzer, K. W.

“…The intrinsic mobility of intracellular H + ions was investigated by confocally imaging the longitudinal movement of acid inside rabbit ventricular myocytes…”
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Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells by Buckler, K J, Vaughan‐Jones, R D

“…1. We have studied the effects of hypoxia on membrane potential and [Ca2+]i in enzymically isolated type I cells of the neonatal rat carotid body (the…”
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Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain by Stewart, A K, Kurschat, C E, Vaughan-Jones, R D, Shmukler, B E, Alper, S L

“…The widely expressed anion exchanger polypeptide AE2/SLC4A2 is acutely inhibited by acidic intracellular (pH i ), by acidic extracellular pH (pH o ), and by…”
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Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH by Stewart, A K, Kurschat, C E, Burns, D, Banger, N, Vaughan-Jones, R D, Alper, S L

“…Activity of the AE2/SLC4A2 anion exchanger is modulated acutely by pH, influencing the transporter's role in regulation of intracellular pH (pH(i)) and…”
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Facilitation of intracellular H+ ion mobility by CO2/HCO3− in rabbit ventricular myocytes is regulated by carbonic anhydrase by Spitzer, K. W., Skolnick, R. L., Peercy, B. E., Keener, J. P., Vaughan‐Jones, R. D.

“…Intracellular H+ mobility was estimated in the rabbit isolated ventricular myocyte by diffusing HCl into the cell from a patch pipette, while imaging pHi…”
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Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte by Lagadic‐Gossmann, D, Buckler, K J, Vaughan‐Jones, R D

“…1. Intracellular pH (pHi) was recorded ratiometrically in isolated guinea-pig ventricular myocytes using the pH-sensitive fluoroprobe, carboxy-SNARF-1…”
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S0859, an N‐cyanosulphonamide inhibitor of sodium‐bicarbonate cotransport in the heart by Ch'En, F F‐T, Villafuerte, F C, Swietach, P, Cobden, P M, Vaughan‐Jones, R D

“…Background and purpose: Intracellular pH (pHi) in heart is regulated by sarcolemmal H+‐equivalent transporters such as Na+‐H+ exchange (NHE) and Na+‐HCO3 −…”
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A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes by Stewart, A. K., Boyd, C. A. R., Vaughan‐Jones, R. D.

“…The spatial and temporal distribution of intracellular H + ions in response to activation of a proton-coupled dipeptide transporter localized at the apical…”
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Effect of intracellular pH on spontaneous Ca2+ sparks in rat ventricular myocytes by Balnave, C D, Vaughan-Jones, R D

“…A fall of intracellular pH (pH i ) typically depresses cardiac contractility. Among the many mechanisms underlying this depression, an inhibitory effect of…”
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Na(+)-HCO3- symport in the sheep cardiac Purkinje fibre by Dart, C, Vaughan‐Jones, R D

“…1. Intracellular pH (pHi) was recorded in isolated sheep cardiac Purkinje fibres using liquid sensor ion-selective microelectrodes in conjunction with…”
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Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle by Gasser, R N, Vaughan‐Jones, R D

“…1. Ischaemia was simulated in the isolated sheep cardiac Purkinje fibre and guinea-pig papillary muscle by immersing the preparations in paraffin oil…”
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Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle by Bountra, C, Vaughan‐Jones, R D

“…1. Intracellular pH (pHi) and Na+ activity were recorded (ion-selective microelectrodes) in guinea-pig papillary muscle and the sheep cardiac Purkinje fibre…”
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Application of a new pH-sensitive fluoroprobe (carboxy-SNARF-1) for intracellular pH measurement in small, isolated cells by BUCKLER, K. J, VAUGHAN-JONES, R. D

“…We report the use of a new pH-sensitive dual-emission fluoroprobe, carboxy-seminaphthorhodafluor-1 (carboxy-SNARF-1) for ratiometric recording of intracellular…”
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Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat by Buckler, K J, Vaughan‐Jones, R D, Peers, C, Nye, P C

“…1. The dual-emission pH-sensitive fluoroprobe carboxy-SNARF-1 (carboxy-seminaptharhodofluor) was used to measure pHi in type I cells enzymically dispersed from…”
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Effects of extracellular pH, PCO2 and HCO3- on intracellular pH in isolated type-I cells of the neonatal rat carotid body by Buckler, K J, Vaughan‐Jones, R D, Peers, C, Lagadic‐Gossmann, D, Nye, P C

“…1. The effects of changing PCO2 extracellular pH (pHo) and HCO3- on intracellular pH (pHi) were studied in isolated neonatal rat type-I carotid body cells…”
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Extracellular H+ inactivation of Na(+)-H+ exchange in the sheep cardiac Purkinje fibre by Vaughan‐Jones, R D, Wu, M L

“…1. The inhibition of acid extrusion via Na(+)-H+ exchange caused by reducing pHo (extracellular pH) was examined in the sheep cardiac Purkinje fibre…”
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Coupling of dual acid extrusion in the guinea-pig isolated ventricular myocyte to alpha 1- and beta-adrenoceptors by D Lagadic-Gossmann, R D Vaughan-Jones

“…1. Intracellular pH (pHi) was recorded in single, isolated guinea-pig ventricular myocytes using the pH-sensitive fluorophore, carboxy-SNARF-1 (AM-loaded). 2…”
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An investigation of chloride-bicarbonate exchange in the sheep cardiac Purkinje fibre by R D Vaughan-Jones

“…Intracellular Cl activity (aiCl), and intracellular pH (pHi) were measured in isolated sheep cardiac Purkinje fibres using a liquid ion exchanger Cl-selective…”
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