Search Results - "R B Diasio"

Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing by Caudle, K E, Thorn, C F, Klein, T E, Swen, J J, McLeod, H L, Diasio, R B, Schwab, M

“…The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. Detoxifying metabolism of fluoropyrimidines requires…”
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Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity by Nie, Q, Shrestha, S, Tapper, EE, Trogstad‐Isaacson, CS, Bouchonville, KJ, Lee, AM, Wu, R, Jerde, CR, Wang, Z, Kubica, PA, Offer, SM, Diasio, RB

“…Dihydropyrimidine dehydrogenase (DPD; DPYD gene) variants have emerged as reliable predictors of adverse toxicity to the chemotherapy agent 5‐fluorouracil…”
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A DPYD Variant (Y186C) in Individuals of African Ancestry Is Associated With Reduced DPD Enzyme Activity by Offer, S M, Lee, A M, Mattison, L K, Fossum, C, Wegner, N J, Diasio, R B

“…5‐Fluorouracil (5‐FU) is used to treat many aggressive cancers, such as those of the colon, breast, and head and neck. The responses to 5‐FU, with respect to…”
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Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5‐Fluorouracil Sensitivity in an East African Population by Elraiyah, T, Jerde, CR, Shrestha, S, Wu, R, Nie, Q, Giama, NH, Sarangi, V, Roberts, LR, Offer, SM, Diasio, RB

“…Clinical studies have identified specific genetic variants in dihydropyrimidine dehydrogenase (DPD; DPYD gene) as predictors of severe adverse toxicity to the…”
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Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy by Soong, R., Shah, N., Salto-Tellez, M., Tai, B. C., Soo, R. A., Han, H. C., Ng, S. S., Tan, W. L., Zeps, N., Joseph, D., Diasio, R. B., Iacopetta, B.

“…Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked…”
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Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase by SALONGA, D, DANENBERG, K. D, DANENBERG, P. V, JOHNSON, M, METZGER, R, GROSHEN, S, TSAO-WEI, D. D, LENZ, H.-J, LEICHMAN, C. G, LEICHMAN, L, DIASIO, R. B

“…We had previously shown that high gene expressions (mRNA levels) of thymidylate synthase ( TS ; Leichman et al. , J. Clin. Oncol., 15: 3223–3229, 1997) and…”
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Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil by JOHNSON, M. R, HAGEBOUTROS, A, KANGSHENG WANG, HIGH, L, SMITH, J. B, DIASIO, R. B

“…In humans, 80–90% of an administered dose of 5-fluorouracil (5-FU) is degraded by dihydropyrimidine dehydrogenase (DPD; EC 1.3.1.2), the initial…”
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Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance by Diasio, R B, Johnson, M R

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Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy by ZHIHONG LU, RUIWEN ZHANG, CARPENTER, J. T, DIASIO, R. B

“…Dihydropyrimidine dehydrogenase (DPD) is the initial, rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU), one of the most widely used…”
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Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy by JIANG, W, LU, Z, HE, Y, DIASIO, R. B

“…Dihydropyrimidine dehydrogenase (DPD) is the initial, rate-limiting enzyme in the catabolism of 5-fluorouracil, one of the most widely used cancer…”
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Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver : population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy by LU, Z, ZHANG, R, DIASIO, R. B

“…Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (FUra), one of the most widely used…”
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Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency by C H Takimoto, Z H Lu, R Zhang, M D Liang, L V Larson, L R Cantilena, Jr, J L Grem, C J Allegra, R B Diasio, E Chu

“…Patients with decreased dihydropyrimidine dehydrogenase (DPD) activity are at increased risk for experiencing serious adverse reactions following…”
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Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase by FALANY, C. N, JOHNSON, M. R, BARNES, S, DIASIO, R. B

“…In order to establish whether a single enzyme in human liver was capable of conjugating bile acids with both glycine and taurine, a cDNA encoding human liver…”
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Response to "A Case of 5-FU-Related Severe Toxicity Associated With the P.Y186C DPYD Variant" by Offer, S M, Diasio, R B

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Sorivudine and 5‐fluorouracil; a clinically significant drug‐drug interaction due to inhibition of dihydropyrimidine dehydrogenase by Diasio, Robert B.

“…Sorivudine (1‐β‐d‐arabinofuranosyl‐E‐5‐[2‐bromovinyl] uracil; BV‐araU; SQ32,756) is an antimetabolite which is a synthetic analogue of thymidine. This drug has…”
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Clinical pharmacology of 5-fluorouracil by DIASIO, R. B, HARRIS, B. E

“…5-Fluorouracil, first introduced as a rationally synthesized anticancer agent 30 years ago, continues to be widely used in the management of several common…”
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Purification and characterization of dihydropyrimidine dehydrogenase from human liver by ZHI-HONG LU, ZHANG, R, DIASIO, R. B

“…Although dihydropyrimidine dehydrogenase has been purified to varying degrees from several species, very little is known about the human enzyme. The importance…”
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Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion by HARRIS, B. E, SONG, R, SENG-JAW SOONG, DIASIO, R. B

“…The activity of dihydropyrimidine dehydrogenase (DPD) in peripheral blood mononuclear cells and plasma concentration of 5-fluorouracil (FUra) were…”
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Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy by Witzig, T E, Hu, G, Offer, S M, Wellik, L E, Han, J J, Stenson, M J, Dogan, A, Diasio, R B, Gupta, M

“…Protein tyrosine phosphatases such as PTPN6 can be downregulated in various neoplasms. PTPN6 expression by immunohistochemistry in 40 diffuse large B-cell…”
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Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy by Diasio, R B, Lu, Z

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