Search Results - "R Alloway, Rita"

Plasma cell biology: Foundations for targeted therapeutic development in transplantation by Rossi, Amy P., Alloway, Rita R., Hildeman, David, Woodle, E. Steve

“…Solid organ transplantation is a life‐saving procedure for patients with end‐stage organ disease. Over the past 70 years, tremendous progress has been made in…”
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Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial by Alloway, Rita R, Vinks, Alexander A, Fukuda, Tsuyoshi, Mizuno, Tomoyuki, King, Eileen C, Zou, Yuanshu, Jiang, Wenlei, Woodle, E Steve, Tremblay, Simon, Klawitter, Jelena, Klawitter, Jost, Christians, Uwe

“…Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic…”
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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality by Shi, Tiffany, Burg, Ashley R, Caldwell, J Timothy, Roskin, Krishna M, Castro-Rojas, Cyd M, Chukwuma, P Chukwunalu, Gray, George I, Foote, Sara G, Alonso, Jesus A, Cuda, Carla M, Allman, David A, Rush, James S, Regnier, Catherine H, Wieczorek, Grazyna, Alloway, Rita R, Shields, Adele R, Baker, Brian M, Woodle, E Steve, Hildeman, David A

“…Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular…”
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Bortezomib Provides Effective Therapy for Antibody-and Cell-Mediated Acute Rejection by EVERLY, Matthew J, EVERLY, Jason J, CARDI, Michael, WADIH, George, TEVAR, Amit, WOODIE, E. Steve, SUSSKIND, Brian, BRAILEY, Paul, ARENA, Lois J, ALLOWAY, Rita R, ROY-CHAUDHURY, Prabir, GOVIL, Amit, MOGILISHETTY, Gautham, RIKE, Adele H

“…Current antihumoral therapies in transplantation and autoimmune disease do not target the mature antibody-producing plasma cell. Bortezomib is a first in class…”
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Conversion from twice daily tacrolimus capsules to once daily extended‐release tacrolimus (LCP‐Tacro): Phase 2 trial of stable liver transplant recipients by Alloway, Rita R., Eckhoff, Devin E., Washburn, W. Kenneth, Teperman, Lewis W.

“…LCP‐Tacro is an extended‐release formulation of tacrolimus designed for once‐daily dosing. Studies in renal transplantation demonstrate greater bioavailability…”
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Proteasome inhibitor-based therapy for antibody-mediated rejection by Walsh, R Carlin, Alloway, Rita R, Girnita, Alin L, Woodle, E Steve

“…The development of donor-specific anti-human leukocyte antigen antibodies (DSAs) following renal transplantation significantly reduces long-term renal graft…”
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Proteasome Inhibitor-Based Primary Therapy for Antibody-Mediated Renal Allograft Rejection by WALSH, R. Carlin, EVERLY, Jason J, BRAILEY, Paul, RIKE, Adele H, AREND, Lois J, MOGILISHETTY, Gautham, GOVIL, Amit, ROY-CHAUDHURY, Prabir, ALLOWAY, Rita R, WOODLE, E. Steve

“…Rapid and complete elimination of donor-specific anti-human leukocyte antigen antibodies (DSA) during antibody-mediated rejection (AMR) is rarely achieved with…”
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A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition by Emoto, Chie, Johnson, Trevor N., Hahn, David, Christians, Uwe, Alloway, Rita R., Vinks, Alexander A., Fukuda, Tsuyoshi

“…Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of…”
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Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study by Rogers, Christin C, Alloway, Rita R, Alexander, J. Wesley, Cardi, Michael, Trofe, Jennifer, Vinks, Alexander A

“…:  Background:  Promising data regarding the safety and efficacy of gastric bypass surgery (GBS) as an option to address obesity in the transplant population…”
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Belatacept Removal by Plasmapheresis: Dose Adjustments and Clinical Recommendations by Wilson, Nicole K, Tremblay, Simon, Shields, Adele R, Woodle, E Steve, Alloway, Rita R, Vinks, Alexander A, Miyagawa, Bradley, Mizuno, Tomoyuki

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One-Year Outcomes of the Multi-Center StudY to Transplant Hepatitis C-InfeCted kidneys (MYTHIC) Trial by Sise, Meghan Elizabeth, Goldberg, David Seth, Schaubel, Douglas Earl, Fontana, Robert J., Kort, Jens J., Alloway, Rita R., Durand, Christine M., Blumberg, Emily A., Woodle, E. Steve, Sherman, Kenneth E., Brown, Robert S., Friedewald, John J., Desai, Niraj M., Sultan, Samuel T., Levitsky, Josh, Lee, Meghan D., Strohbehn, Ian A., Landis, J. Richard, Fernando, Melissa, Gustafson, Jenna L., Chung, Raymond T., Reese, Peter Philip

“…Transplanting kidneys from hepatitis C virus (HCV) viremic donors into HCV-negative patients (HCV D-RNA-positive/R-negative) has evolved from experimental to…”
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Incorporating Patients’ Values and Preferences Into Decision Making About Transplantation of HCV-Naïve Recipients With Kidneys From HCV-Viremic Donors: A Feasibility Study by Eckman, Mark H., Adejare, Adeboye A., Duncan, Heather, Woodle, E. Steve, Thakar, Charuhas V., Alloway, Rita R., Sherman, Kenneth E.

“…Introduction While use of (hepatitis C virus) HCV-viremic kidneys may result in net benefit for the average end-stage kidney disease (ESKD) patient awaiting…”
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Evidence of a clinically significant drug‐drug interaction between cannabidiol and tacrolimus by Leino, Abbie D., Emoto, Chie, Fukuda, Tsuyoshi, Privitera, Michael, Vinks, Alexander A., Alloway, Rita R.

“…Cannabidiol (CBD), a major purified nonpsychoactive component of cannabis with anticonvulsant properties, was approved by the U.S. Food and Drug Administration…”
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Management of Antibody-Mediated Rejection in Transplantation by Sadaka, Basma, PharmD, MsCR, BCPS, Alloway, Rita R., PharmD, Woodle, E. Steve, MD

“…Despite intensive traditional immunosuppressive therapy, rates of graft loss have approximated 15% to 20% at 1 year following antibody-mediated rejection (AMR)…”
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Clinical and investigational use of proteasome inhibitors for transplant rejection by Sadaka, Basma, Alloway, Rita R, Woodle, E Steve

“…The presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) in patients experiencing acute cellular rejection and antibody-mediated…”
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Mounting Clinical Evidence With Tacrolimus Generic Products by Alloway, Rita R

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The Effect of CYP3A5 and MDR1 Polymorphic Expression on Cyclosporine Oral Disposition in Renal Transplant Patients by Yates, Charles R., Zhang, Wenhui, Song, Pengfei, Li, Shen, Gaber, A. Osama, Kotb, Malak, Honaker, Marsha R., Alloway, Rita R., Meibohm, Bernd

“…Variability in CYP3A (CYP3A4/5) and P‐glycoprotein (human MDR1 gene product) activity underlies interindividual differences in oral cyclosporine (CsA)…”
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Cardiovascular risk, cardiovascular events, and metabolic syndrome in renal transplantation: comparison of early steroid withdrawal and chronic steroids by Rike, Adele H., Mogilishetty, Gautham, Alloway, Rita R., Succop, Paul, Roy-Chaudhury, Prabir, Cardi, Michael, Kaiser, Tiffany E., Thomas, Mark, Woodle, E. Steve

“…: Background:  Cardiovascular disease (CVD) is the leading cause of death with a functioning graft in renal transplant recipients. The purpose of this study…”
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Clinical Evaluation of Modified Release and Immediate Release Tacrolimus Formulations by Tremblay, Simon, Alloway, Rita R.

“…The science of drug delivery has evolved considerably and has led to the development of multiple sustained release formulations. Each of these formulations can…”
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Contrast-Induced Nephropathy in Renal Transplant Recipients: A Single Center Experience by Abu Jawdeh, Bassam G, Leonard, Anthony C, Sharma, Yuvraj, Katipally, Swapna, Shields, Adele R, Alloway, Rita R, Woodle, E Steve, Thakar, Charuhas V

“…Contrast-induced nephropathy (CIN) in native kidneys is associated with a significant increase in mortality and morbidity. Data regarding CIN in renal…”
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