Search Results - "Rüschoff, Jan H."

Automated Gleason grading of prostate cancer tissue microarrays via deep learning by Arvaniti, Eirini, Fricker, Kim S., Moret, Michael, Rupp, Niels, Hermanns, Thomas, Fankhauser, Christian, Wey, Norbert, Wild, Peter J., Rüschoff, Jan H., Claassen, Manfred

“…The Gleason grading system remains the most powerful prognostic predictor for patients with prostate cancer since the 1960s. Its application requires…”
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Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma by Bihr, Svenja, Ohashi, Riuko, Moore, Ariane L., Rüschoff, Jan H., Beisel, Christian, Hermanns, Thomas, Mischo, Axel, Corrò, Claudia, Beyer, Jörg, Beerenwinkel, Niko, Moch, Holger, Schraml, Peter

“…Bi-allelic inactivation of the VHL gene on chromosome 3p is the characteristic feature in most clear cell renal cell carcinomas (ccRCC). Frequent gene…”
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Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins by Shao, Wenguang, Guo, Tiannan, Toussaint, Nora C., Xue, Peng, Wagner, Ulrich, Li, Li, Charmpi, Konstantina, Zhu, Yi, Wu, Jianmin, Buljan, Marija, Sun, Rui, Rutishauser, Dorothea, Hermanns, Thomas, Fankhauser, Christian Daniel, Poyet, Cedric, Ljubicic, Jelena, Rupp, Niels, Rüschoff, Jan H., Zhong, Qing, Beyer, Andreas, Ji, Jiafu, Collins, Ben C., Liu, Yansheng, Rätsch, Gunnar, Wild, Peter J., Aebersold, Ruedi

“…Deterioration of biomolecules in clinical tissues is an inevitable pre-analytical process, which affects molecular measurements and thus potentially confounds…”
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Convergent network effects along the axis of gene expression during prostate cancer progression by Charmpi, Konstantina, Guo, Tiannan, Zhong, Qing, Wagner, Ulrich, Sun, Rui, Toussaint, Nora C, Fritz, Christine E, Yuan, Chunhui, Chen, Hao, Rupp, Niels J, Christiansen, Ailsa, Rutishauser, Dorothea, Rüschoff, Jan H, Fankhauser, Christian, Saba, Karim, Poyet, Cedric, Hermanns, Thomas, Oehl, Kathrin, Moore, Ariane L, Beisel, Christian, Calzone, Laurence, Martignetti, Loredana, Zhang, Qiushi, Zhu, Yi, Martínez, María Rodríguez, Manica, Matteo, Haffner, Michael C, Aebersold, Ruedi, Wild, Peter J, Beyer, Andreas

“…Tumor-specific genomic aberrations are routinely determined by high-throughput genomic measurements. It remains unclear how complex genome alterations affect…”
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Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09) by Rothermundt, Christian, Hayoz, Stefanie, Templeton, Arnoud J, Winterhalder, Ralph, Strebel, Räto T, Bärtschi, Daniela, Pollak, Michael, Lui, Lillianne, Endt, Kathrin, Schiess, Ralph, Rüschoff, Jan H, Cathomas, Richard, Gillessen, Silke

“…Abstract Background There is evidence linking metformin to improved prostate cancer (PCa)-related outcomes. Objective To evaluate treatment with metformin in…”
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Author Correction: Automated Gleason grading of prostate cancer tissue microarrays via deep learning by Arvaniti, Eirini, Fricker, Kim S., Moret, Michael, Rupp, Niels, Hermanns, Thomas, Fankhauser, Christian, Wey, Norbert, Wild, Peter J., Rüschoff, Jan H., Claassen, Manfred

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Targeting ALK in Neuroendocrine Tumors of the Lung by Akhoundova, Dilara, Haberecker, Martina, Fritsch, Ralph, Höller, Sylvia, Kiessling, Michael K., Rechsteiner, Markus, Rüschoff, Jan H., Curioni-Fontecedro, Alessandra

“…Background Anaplastic lymphoma kinase ( ALK ) rearrangements are known oncogenic drivers in non-small cell lung cancer (NSCLC). Few case reports described the…”
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The Morphological Spectrum of Papillary Renal Cell Carcinoma and Prevalence of Provisional/Emerging Renal Tumor Entities with Papillary Growth by Lobo, João, Ohashi, Riuko, Helmchen, Birgit M., Rupp, Niels J., Rüschoff, Jan H., Moch, Holger

“…Renal cell carcinoma (RCC) represents a heterogeneous disease, encompassing an increasing number of tumor subtypes. Post-2016, the World Health Organization…”
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Identification of Urine Biomarkers to Improve Eligibility for Prostate Biopsy and Detect High-Grade Prostate Cancer by Alijaj, Nagjie, Pavlovic, Blaz, Martel, Paul, Rakauskas, Arnas, Cesson, Valérie, Saba, Karim, Hermanns, Thomas, Oechslin, Pascal, Veit, Markus, Provenzano, Maurizio, Rüschoff, Jan H, Brada, Muriel D, Rupp, Niels J, Poyet, Cédric, Derré, Laurent, Valerio, Massimo, Banzola, Irina, Eberli, Daniel

“…PCa screening is based on the measurements of the serum prostate specific antigen (PSA) to select men with higher risks for tumors and, thus, eligible for…”
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Ultra-deep sequencing confirms immunohistochemistry as a highly sensitive and specific method for detecting BRAF V600E mutations in colorectal carcinoma by Rössle, Matthias, Sigg, Michèle, Rüschoff, Jan H, Wild, Peter J, Moch, Holger, Weber, Achim, Rechsteiner, Markus P

“…The activating BRAF (V600) mutation is a well-established negative prognostic biomarker in metastatic colorectal carcinoma (CRC). A recently developed…”
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Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI by Laudicella, Riccardo, Rüschoff, Jan H., Ferraro, Daniela A., Brada, Muriel D., Hausmann, Daniel, Mebert, Iliana, Maurer, Alexander, Hermanns, Thomas, Eberli, Daniel, Rupp, Niels J., Burger, Irene A.

“…Purpose Recently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane…”
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Phase 2 Trial of Single-agent Everolimus in Chemotherapy-naive Patients with Castration-resistant Prostate Cancer (SAKK 08/08) by Templeton, Arnoud J, Dutoit, Valérie, Cathomas, Richard, Rothermundt, Christian, Bärtschi, Daniela, Dröge, Cornelia, Gautschi, Oliver, Borner, Markus, Fechter, Eva, Stenner, Frank, Winterhalder, Ralph, Müller, Beat, Schiess, Ralph, Wild, Peter J, Rüschoff, Jan H, Thalmann, George, Dietrich, Pierre-Yves, Aebersold, Ruedi, Klingbiel, Dirk, Gillessen, Silke

“…Abstract Background The phosphatase and tensin homolog ( PTEN ) tumor suppressor gene is deregulated in many advanced prostate cancers, leading to activation…”
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What’s behind 68Ga-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns by Rüschoff, Jan H., Ferraro, Daniela A., Muehlematter, Urs J., Laudicella, Riccardo, Hermanns, Thomas, Rodewald, Ann-Katrin, Moch, Holger, Eberli, Daniel, Burger, Irene A., Rupp, Niels J.

“…Purpose Prostate-specific membrane antigen (PSMA-) PET has become a promising tool in staging and restaging of prostate carcinoma (PCa). However, specific…”
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Immunohistochemical ERG positivity is associated with decreased PSMA expression and lower visibility in corresponding [ 68 Ga]Ga-PSMA-11 PET scans of primary prostate cancer by Rupp, Niels J, Freiberger, Sandra N, Ferraro, Daniela A, Laudicella, Riccardo, Heimer, Jakob, Muehlematter, Urs J, Poyet, Cédric, Moch, Holger, Eberli, Daniel, Rüschoff, Jan H, Burger, Irene A

“…TMPRSS2:ERG gene fusion negatively regulates PSMA expression in prostate adenocarcinoma (PCa) cell lines. Therefore, immunohistochemical (IHC) ERG expression,…”
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A novel 5x multiplex immunohistochemical staining reveals PSMA as a helpful marker in prostate cancer with low p504s expression by Rüschoff, Jan H., Stratton, Steven, Roberts, Esteban, Clark, Samantha, Sebastiao, Noemi, Fankhauser, Christian D., Eberli, Daniel, Moch, Holger, Wild, Peter J., Rupp, Niels J.

“…The ability to combine multiple immunohistochemical (IHC) markers within a single tissue section facilitates the evaluation and detection of co-expressions,…”
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Mutational Landscape and Expression of PD-L1 in Patients with Non-Small Cell Lung Cancer Harboring Genomic Alterations of the MET gene by Fischer, Alessa, Bankel, Lorenz, Hiltbrunner, Stefanie, Rechsteiner, Markus, Rüschoff, Jan H., Rushing, Elisabeth Jane, Britschgi, Christian, Curioni-Fontecedro, Alessandra

“…Background Mesenchymal-to-epithelial transition (MET) exon 14 skipping mutations and MET gene amplification occur in 3–5% of non-small cell lung cancer (NSCLC)…”
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Diagnostic Accuracy of Multiparametric MRI versus 68 Ga-PSMA-11 PET/MRI for Extracapsular Extension and Seminal Vesicle Invasion in Patients with Prostate Cancer by Muehlematter, Urs J, Burger, Irene A, Becker, Anton S, Schawkat, Khoschy, Hötker, Andreas M, Reiner, Cäcilia S, Müller, Julian, Rupp, Niels J, Rüschoff, Jan H, Eberli, Daniel, Donati, Olivio F

“…Background Recent studies have reported the additive value of combined gallium 68 ( Ga)-labeled Glu-urea-Lys (Ahx)-HBED-CC ligand targeting the…”
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Author Correction: Automated Gleason grading of prostate cancer tissue microarrays via deep learning by Arvaniti, Eirini, Fricker, Kim S., Moret, Michael, Rupp, Niels, Hermanns, Thomas, Fankhauser, Christian, Wey, Norbert, Wild, Peter J., Rüschoff, Jan H., Claassen, Manfred

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
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KRAS , BRAF, and TP53 Deep Sequencing for Colorectal Carcinoma Patient Diagnostics by Rechsteiner, Markus, von Teichman, Adriana, Rüschoff, Jan H, Fankhauser, Niklaus, Pestalozzi, Bernhard, Schraml, Peter, Weber, Achim, Wild, Peter, Zimmermann, Dieter, Moch, Holger

“…In colorectal carcinoma, KRAS (alias Ki-ras ) and BRAF mutations have emerged as predictors of resistance to anti–epidermal growth factor receptor antibody…”
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Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity by Zhong, Qing, Rüschoff, Jan H., Guo, Tiannan, Gabrani, Maria, Schüffler, Peter J., Rechsteiner, Markus, Liu, Yansheng, Fuchs, Thomas J., Rupp, Niels J., Fankhauser, Christian, Buhmann, Joachim M., Perner, Sven, Poyet, Cédric, Blattner, Miriam, Soldini, Davide, Moch, Holger, Rubin, Mark A., Noske, Aurelia, Rüschoff, Josef, Haffner, Michael C., Jochum, Wolfram, Wild, Peter J.

“…Recent large-scale genome analyses of human tissue samples have uncovered a high degree of genetic alterations and tumour heterogeneity in most tumour…”
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