Search Results - "Rühl, Ralph"

Host‐related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans by Bohn, Torsten, Desmarchelier, Charles, Dragsted, Lars O., Nielsen, Charlotte S., Stahl, Wilhelm, Rühl, Ralph, Keijer, Jaap, Borel, Patrick

“…Carotenoid dietary intake and their endogenous levels have been associated with a decreased risk of several chronic diseases. There are indications that…”
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β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion by Bohn, Torsten, Desmarchelier, Charles, El, Sedef N., Keijer, Jaap, van Schothorst, Evert, Rühl, Ralph, Borel, Patrick

“…β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive…”
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Mechanistic aspects of carotenoid health benefits – where are we now? by Bohn, Torsten, Bonet, M. Luisa, Borel, Patrick, Keijer, Jaap, Landrier, Jean-Francois, Milisav, Irina, Ribot, Joan, Riso, Patrizia, Winklhofer-Roob, Brigitte, Sharoni, Yoav, Corte-Real, Joana, van Helden, Yvonne, Loizzo, Monica Rosa, Poljšak, Borut, Porrini, Marisa, Roob, Johannes, Trebše, Polonca, Tundis, Rosa, Wawrzyniak, Agata, Rühl, Ralph, Dulińska-Litewka, Joanna

“…Dietary intake and tissue levels of carotenoids have been associated with a reduced risk of several chronic diseases, including cardiovascular diseases, type 2…”
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Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non‐affected skin of human atopic dermatitis patients by Töröcsik, Daniel, Weise, Christin, Gericke, Janine, Szegedi, Andrea, Lucas, Renata, Mihaly, Johanna, Worm, Margitta, Rühl, Ralph

“…Lipoxygenases (LOX) and cyclooxygenase (COX) are the main enzymes for PUFA metabolism to highly bio‐active prostaglandins, leukotrienes, thromboxanes,…”
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From carotenoid intake to carotenoid blood and tissue concentrations – implications for dietary intake recommendations by Böhm, Volker, Lietz, Georg, Olmedilla-Alonso, Begoña, Phelan, David, Reboul, Emmanuelle, Bánati, Diana, Borel, Patrick, Corte-Real, Joana, de Lera, Angel R, Desmarchelier, Charles, Dulinska-Litewka, Joanna, Landrier, Jean-Francois, Milisav, Irina, Nolan, John, Porrini, Marisa, Riso, Patrizia, Roob, Johannes M, Valanou, Elisavet, Wawrzyniak, Agata, Winklhofer-Roob, Brigitte M, Rühl, Ralph, Bohn, Torsten

“…Abstract There is uncertainty regarding carotenoid intake recommendations, because positive and negative health effects have been found or are correlated with…”
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9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5 by Rühl, Ralph, Krezel, Wojciech, de Lera, Angel R

“…The identity of the endogenous RXR ligand has not been conclusively determined, even though several compounds of natural origin, including retinoids and fatty…”
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Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling by Krężel, Wojciech, Rivas, Aurea, Szklenar, Monika, Ciancia, Marion, Alvarez, Rosana, de Lera, Angel R, Rühl, Ralph

“…Vitamin A is a family of derivatives synthesized from carotenoids acquired from the diet and can be converted in animals to bioactive forms essential for life…”
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A transgenic reporter mouse model for in vivo assessment of retinoic acid receptor transcriptional activation by Carlsen, Harald, Ebihara, Kanae, Kuwata, Nobuyo H, Kuwata, Kazuhisa, Aydemir, Gamze, Rühl, Ralph, Blomhoff, Rune

“…Vitamin A is essential for a wide range of life processes throughout embryogenesis to adult life. With the aim of developing an model to monitor retinoic acid…”
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An Endogenous Mammalian Retinoid X Receptor Ligand, At Last by de Lera, Ángel R., Krezel, Wojciech, Rühl, Ralph

“…9‐cis‐Retinoic acid was identified and claimed to be the endogenous ligand of the retinoid X receptors (RXRs) in 1992. Since then, the endogenous presence of…”
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9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice by Rühl, Ralph, Krzyżosiak, Agnieszka, Niewiadomska-Cimicka, Anna, Rochel, Natacha, Szeles, Lajos, Vaz, Belén, Wietrzych-Schindler, Marta, Álvarez, Susana, Szklenar, Monika, Nagy, Laszlo, de Lera, Angel R, Krężel, Wojciech

“…The retinoid X receptors (RXRs) are ligand-activated transcription factors which heterodimerize with a number of nuclear hormone receptors, thereby controlling…”
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PPARγ controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells by Szatmari, Istvan, Pap, Attila, Rühl, Ralph, Ma, Jiang-Xing, Illarionov, Petr A., Besra, Gurdyal S., Rajnavolgyi, Eva, Dezso, Balazs, Nagy, Laszlo

“…Dendritic cells (DCs) expressing CD1d, a molecule responsible for lipid antigen presentation, are capable of enhancing natural killer T (iNKT) cell…”
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Reduced retinoids and retinoid receptors' expression in pancreatic cancer: A link to patient survival by Bleul, Tim, Rühl, Ralph, Bulashevska, Svetlana, Karakhanova, Svetlana, Werner, Jens, Bazhin, Alexandr V.

“…Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. All‐trans retinoic acid (ATRA) is the major physiologically…”
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Saturated and monounsaturated fatty acids in membranes are determined by the gene expression of their metabolizing enzymes SCD1 and ELOVL6 regulated by the intake of dietary fat by Weiss-Hersh, Kathrin, Garcia, Ada L., Marosvölgyi, Tamás, Szklenár, Mónika, Decsi, Tamás, Rühl, Ralph

“…Purpose We investigated the effect of dietary fats on the incorporation of saturated (SAFAs) and monounsaturated dietary fatty acids (MUFAs) into plasma…”
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Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro-vitamin A activity transmitted via RAR signaling by Aydemir, Gamze, Kasiri, Yasamin, Bartók, Emöke-Márta, Birta, Eszter, Fröhlich, Kati, Böhm, Volker, Mihaly, Johanna, Rühl, Ralph

“…Scope The aim of this study was to compare if lycopene also possesses pro‐vitamin A (VA) activity comparable to known VA derivatives. Materials and methods We…”
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Organic Synthesis of New Putative Lycopene Metabolites and Preliminary Investigation of Their Cell-Signaling Effects by Reynaud, Eric, Aydemir, Gamze, Rühl, Ralph, Dangles, Olivier, Caris-Veyrat, Catherine

“…Tomato is the main dietary source of lycopene, a carotenoid that is known to have protective effects on health and whose metabolites could also be involved in…”
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Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG-Mutated Atopic Dermatitis by Blunder, Stefan, Rühl, Ralph, Moosbrugger-Martinz, Verena, Krimmel, Christine, Geisler, Anita, Zhu, Huiting, Crumrine, Debra, Elias, Peter M., Gruber, Robert, Schmuth, Matthias, Dubrac, Sandrine

“…Loss-of-function mutations in the FLG gene cause ichthyosis vulgaris (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (AD)…”
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Is vitamin A an antioxidant? by Bohn, Torsten, Böhm, Volker, Dulińska-Litewka, Joanna, Landrier, Jean-Francois, Bánáti, Diána, Kucuk, Omer, Borel, Patrick, Canas, Jose A, Rühl, Ralph

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Human nutritional relevance and suggested nutritional guidelines for vitamin A5/X and provitamin A5/X by Bohn, Torsten, Hellman-Regen, Julian, de Lera, Angel R, Böhm, Volker, Rühl, Ralph

“…Abstract In the last century, vitamin A was identified that included the nutritional relevant vitamin A1 / provitamin A1, as well as the vitamin A2 pathway…”
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Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry by Rühl, Ralph

“…Retinoic acid isomers, 4‐oxo‐retinoic acid isomers and retinol are present in the serum of mammals. In this study a high‐performance liquid chromatography…”
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Macrophages engulfing apoptotic cells produce nonclassical retinoids to enhance their phagocytic capacity by Sarang, Zsolt, Joós, Gergely, Garabuczi, Éva, Rühl, Ralph, Gregory, Christopher D, Szondy, Zsuzsa

“…Previous work in our laboratory has shown that transglutaminase 2 (TG2) acting as a coreceptor for integrin β3 is required for proper phagocytosis of apoptotic…”
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