Search Results - "Rüegg, Markus A."

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c by Hagiwara, Asami, Cornu, Marion, Cybulski, Nadine, Polak, Pazit, Betz, Charles, Trapani, Francesca, Terracciano, Luigi, Heim, Markus H., Rüegg, Markus A., Hall, Michael N.

“…Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to…”
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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia by Ham, Daniel J., Börsch, Anastasiya, Lin, Shuo, Thürkauf, Marco, Weihrauch, Martin, Reinhard, Judith R., Delezie, Julien, Battilana, Fabienne, Wang, Xueyong, Kaiser, Marco S., Guridi, Maitea, Sinnreich, Michael, Rich, Mark M., Mittal, Nitish, Tintignac, Lionel A., Handschin, Christoph, Zavolan, Mihaela, Rüegg, Markus A.

“…With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing…”
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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy by Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

“…Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3…”
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WNT7B promotes bone formation in part through mTORC1 by Chen, Jianquan, Tu, Xiaolin, Esen, Emel, Joeng, Kyu Sang, Lin, Congxin, Arbeit, Jeffrey M, Rüegg, Markus A, Hall, Michael N, Ma, Liang, Long, Fanxin

“…WNT signaling has been implicated in both embryonic and postnatal bone formation. However, the pertinent WNT ligands and their downstream signaling mechanisms…”
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Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice by Venkatesh, Aditya, Ma, Shan, Le, Yun Z, Hall, Michael N, Rüegg, Markus A, Punzo, Claudio

“…Retinitis pigmentosa (RP) is an inherited photoreceptor degenerative disorder that results in blindness. The disease is often caused by mutations in genes that…”
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BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle by Delezie, Julien, Weihrauch, Martin, Maier, Geraldine, Tejero, Rocío, Ham, Daniel J., Gill, Jonathan F., Karrer-Cardel, Bettina, Rüegg, Markus A., Tabares, Lucía, Handschin, Christoph

“…Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of…”
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Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9 by Thürkauf, Marco, Lin, Shuo, Oliveri, Filippo, Grimm, Dirk, Platt, Randall J., Rüegg, Markus A.

“…Molecular screens comparing different disease states to identify candidate genes rely on the availability of fast, reliable and multiplexable systems to…”
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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice by Inoki, Ken, Mori, Hiroyuki, Wang, Junying, Suzuki, Tsukasa, Hong, SungKi, Yoshida, Sei, Blattner, Simone M, Ikenoue, Tsuneo, Rüegg, Markus A, Hall, Michael N, Kwiatkowski, David J, Rastaldi, Maria P, Huber, Tobias B, Kretzler, Matthias, Holzman, Lawrence B, Wiggins, Roger C, Guan, Kun-Liang

“…Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and type 2 diabetics. Podocyte dysfunction is postulated to be a critical…”
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mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation by Ding, Xiaolei, Bloch, Wilhelm, Iden, Sandra, Rüegg, Markus A., Hall, Michael N., Leptin, Maria, Partridge, Linda, Eming, Sabine A.

“…Mammalian target of rapamycin (mTOR), a regulator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or mTORC2. The…”
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I by Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the…”
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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21 by Guridi, Maitea, Tintignac, Lionel A, Lin, Shuo, Kupr, Barbara, Castets, Perrine, Rüegg, Markus A

“…Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the…”
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Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype by McKee, Karen K, Crosson, Stephanie C, Meinen, Sarina, Reinhard, Judith R, Rüegg, Markus A, Yurchenco, Peter D

“…Mutations in laminin α2-subunit (Lmα2, encoded by LAMA2) are linked to approximately 30% of congenital muscular dystrophy cases. Mice with a homozygous…”
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Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice by SHENDE, Pankaj, PLAISANCE, Isabelle, PEDRAZZINI, Thierry, BRINK, Marijke, MORANDI, Christian, PELLIEUX, Corinne, BERTHONNECHE, Corinne, ZORZATO, Francesco, KRISHNAN, Jaya, LERCH, Rene, HALL, Michael N, RÜEGG, Markus A

“…Cardiac hypertrophy involves growth responses to a variety of stimuli triggered by increased workload. It is an independent risk factor for heart failure and…”
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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive by Hall, Michael N, Jacinto, Estela, Loewith, Robbie, Schmidt, Anja, Lin, Shuo, Rüegg, Markus A, Hall, Alan

“…The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of cell growth. In budding yeast, TOR is found in structurally and…”
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Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA by Donadon, Irving, Bussani, Erica, Riccardi, Federico, Licastro, Danilo, Romano, Giulia, Pianigiani, Giulia, Pinotti, Mirko, Konstantinova, Pavlina, Evers, Melvin, Lin, Shuo, Rüegg, Markus A, Pagani, Franco

“…Abstract Spinal Muscular Atrophy results from loss-of-function mutations in SMN1 but correcting aberrant splicing of SMN2 offers hope of a cure. However,…”
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Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology by Thomanetz, Venus, Angliker, Nico, Cloëtta, Dimitri, Lustenberger, Regula M, Schweighauser, Manuel, Oliveri, Filippo, Suzuki, Noboru, Rüegg, Markus A

“…The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein complexes called mTORC1 and mTORC2. Whereas mTORC1 is known to regulate cell…”
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Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology by Ruegsegger, Céline, Stucki, David M., Steiner, Silvio, Angliker, Nico, Radecke, Julika, Keller, Eva, Zuber, Benoît, Rüegg, Markus A., Saxena, Smita

“…Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature…”
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Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner by Zhang, Lianjun, Tschumi, Benjamin O., Lopez-Mejia, Isabel C., Oberle, Susanne G., Meyer, Marten, Samson, Guerric, Rüegg, Markus A., Hall, Michael N., Fajas, Lluis, Zehn, Dietmar, Mach, Jean-Pierre, Donda, Alena, Romero, Pedro

“…Upon infection, antigen-specific naive CD8 T cells are activated and differentiate into short-lived effector cells (SLECs) and memory precursor cells (MPECs)…”
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Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise by Hodson, Nathan, McGlory, Chris, Oikawa, Sara Y, Jeromson, Stewart, Song, Zhe, Rüegg, Markus A, Hamilton, D Lee, Phillips, Stuart M, Philp, Andrew

“…Mechanistic target of rapamycin (mTOR) resides as two complexes within skeletal muscle. mTOR complex 1 [mTORC1-regulatory associated protein of mTOR (Raptor)…”
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Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle by Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, Rüegg, Markus A.

“…Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is…”
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