Search Results - "Rüdiger Burmester, Gerd"

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus by Alexander, Tobias, Sarfert, Ramona, Klotsche, Jens, Kühl, Anja A, Rubbert-Roth, Andrea, Lorenz, Hannes-Martin, Rech, Jürgen, Hoyer, Bimba F, Cheng, Qingyu, Waka, Aderajew, Taddeo, Adriano, Wiesener, Michael, Schett, Georg, Burmester, Gerd-Rüdiger, Radbruch, Andreas, Hiepe, Falk, Voll, Reinhard E

“…To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in…”
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Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus by von Spee-Mayer, Caroline, Siegert, Elise, Abdirama, Dimas, Rose, Angelika, Klaus, Anika, Alexander, Tobias, Enghard, Philipp, Sawitzki, Birgit, Hiepe, Falk, Radbruch, Andreas, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela, Humrich, Jens Y

“…Defects in regulatory T cell (Treg) biology have been associated with human systemic autoimmune diseases, such as systemic lupus erythematosus (SLE). However,…”
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Safety of Ixekizumab in Patients With Psoriatic Arthritis: Results From a Pooled Analysis of Three Clinical Trials by Mease, Philip, Roussou, Euthalia, Burmester, Gerd‐Rüdiger, Goupille, Philippe, Gottlieb, Alice, Moriarty, Susan R., Benichou, Olivier, Adams, David H., Xu, Wen, Nash, Peter

“…Objective To evaluate ixekizumab safety in adults with psoriatic arthritis (PsA). Methods Safety data from 2 integrated data sets are presented: 1) 24‐week,…”
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Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE by Humrich, Jens Y, von Spee-Mayer, Caroline, Siegert, Elise, Alexander, Tobias, Hiepe, Falk, Radbruch, Andreas, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela

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Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial by Nash, Peter, Prof, Kirkham, Bruce, Prof, Okada, Masato, MD, Rahman, Proton, Prof, Combe, Benard, Prof, Burmester, Gerd-Ruediger, Prof, Adams, David H, PhD, Kerr, Lisa, MSPH, Lee, Chin, MD, Shuler, Catherine L, MS, Genovese, Mark, Prof

“…Summary Background Patients who have had inadequate response to tumour necrosis factor inhibitors have fewer treatment options and are generally more treatment…”
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The Diagnosis and Treatment of Sjögren's Syndrome by Stefanski, Ana-Luisa, Tomiak, Christian, Pleyer, Uwe, Dietrich, Thomas, Burmester, Gerd Rüdiger, Dörner, Thomas

“…Sjögren's syndrome is one of the more common inflammatory rheumatological diseases, with a prevalence of at least 0.4% in Germany. This review is based on…”
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Pausing methotrexate improves immunogenicity of COVID-19 vaccination in elderly patients with rheumatic diseases by Arumahandi de Silva, Amanthi Nadira, Frommert, Leonie Maria, Albach, Fredrik N, Klotsche, Jens, Scholz, Veronika, Jeworowski, Lara Maria, Schwarz, Tatjana, Ten Hagen, Alexander, Zernicke, Jan, Corman, Victor Max, Drosten, Christian, Burmester, Gerd-Rüdiger, Biesen, Robert

“…To study the effect of methotrexate (MTX) and its discontinuation on the humoral immune response after COVID-19 vaccination in patients with autoimmune…”
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Head-to-head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis: 2-year efficacy and safety results from the randomised EXXELERATE study by Smolen, Josef S, Prof, Burmester, Gerd-Rüdiger, Prof, Combe, Bernard, Prof, Curtis, Jeffrey R, Prof, Hall, Stephen, MD, Haraoui, Boulos, MD, van Vollenhoven, Ronald, Prof, Cioffi, Christopher, PhD, Ecoffet, Cécile, PharmD, Gervitz, Leon, PhD, Ionescu, Lucian, MD, Peterson, Luke, MS, Fleischmann, Roy, Prof

“…Summary Background To date, head-to-head trials comparing the efficacy and safety of biological disease-modifying antirheumatic drugs within the same class,…”
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Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus by Alexander, Tobias, Sattler, Arne, Templin, Lars, Kohler, Siegfried, Groß, Christian, Meisel, Andreas, Sawitzki, Birgit, Burmester, Gerd-Rüdiger, Arnold, Renate, Radbruch, Andreas, Thiel, Andreas, Hiepe, Falk

“…Recent data debate the suitability of Helios, an Ikaros family member, as a marker for thymic-derived regulatory T cells (Treg). Nevertheless, Foxp3(+)…”
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Towards in situ tissue repair: Human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2 by Ringe, Jochen, Strassburg, Sandra, Neumann, Katja, Endres, Michaela, Notter, Michael, Burmester, Gerd-Rüdiger, Kaps, Christian, Sittinger, Michael

“…The recruitment of bone marrow CD34− mesenchymal stem‐ and progenitor cells (MSC) and their subsequent differentiation into distinct tissues is the…”
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A Human Osteochondral Tissue Model Mimicking Cytokine-Induced Key Features of Arthritis In Vitro by Damerau, Alexandra, Pfeiffenberger, Moritz, Weber, Marie-Christin, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Gaber, Timo, Lang, Annemarie

“…Adequate tissue engineered models are required to further understand the (patho)physiological mechanism involved in the destructive processes of cartilage and…”
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Exogenous and Endogenous Glucocorticoids in Rheumatic Diseases by BUTTGEREIT, Frank, BURMESTER, Gerd-Rüdiger, STRAUB, Rainer H, SEIBEL, Markus J, HONG ZHOU

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A Phase III Study Evaluating Continuation, Tapering, and Withdrawal of Certolizumab Pegol After One Year of Therapy in Patients With Early Rheumatoid Arthritis by Weinblatt, Michael E., Bingham, Clifton O., Burmester, Gerd‐Rüdiger, Bykerk, Vivian P., Furst, Daniel E., Mariette, Xavier, van der Heijde, Désirée, van Vollenhoven, Ronald, VanLunen, Brenda, Ecoffet, Cécile, Cioffi, Christopher, Emery, Paul

“…Objective In disease‐modifying antirheumatic drug–naive patients with early rheumatoid arthritis (RA) who had achieved sustained low disease activity (a…”
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Mapping urinary chemokines in human lupus nephritis: Potentially redundant pathways recruit CD4+ and CD8+ T cells and macrophages by Klocke, Jan, Kopetschke, Katharina, Grießbach, Anna‐Sophie, Langhans, Valerie, Humrich, Jens Y., Biesen, Robert, Dragun, Duska, Radbruch, Andreas, Burmester, Gerd‐Rüdiger, Riemekasten, Gabriela, Enghard, Philipp

“…Renal infiltration of inflammatory cells contributes to the pathogenesis of lupus nephritis (LN). Current knowledge on the recruitment mechanisms relies mainly…”
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Prophylactic antibodies inhibit spike‐specific T and B cell responses after COVID‐19 vaccination by Mei, Henrik E., Schulz, Axel Ronald, Hirseland, Heike, Diekmann, Lisa‐Marie, Habermann, Elisa, Hagen, Alexander, Albach, Fredrik, Burmester, Gerd‐Rüdiger, Grützkau, Andreas, Biesen, Robert

“…Active and passive immunization is used in high‐risk patients to prevent severe courses of COVID‐19, but the impact of prophylactic neutralizing antibodies on…”
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Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab by Hoyer, Bimba F, Mumtaz, Imtiaz M, Loddenkemper, Konstanze, Bruns, Anne, Sengler, Claudia, Hermann, Kay-Geert, Maza, Sofiane, Keitzer, Rolf, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Radbruch, Andreas, Hiepe, Falk

“…Introduction Takayasu arteritis (TA) is a large vessel vasculitis involving the aorta and its major branches. T cell-mediated autoimmunity is thought to play a…”
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Disturbed microcirculation in the hands of patients with systemic sclerosis detected by fluorescence optical imaging: a pilot study by Friedrich, Stefanie, Lüders, Susanne, Werner, Stephanie Gabriele, Glimm, Anne-Marie, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela, Backhaus, Marina, Ohrndorf, Sarah

“…Utilising fluorescence optical imaging (FOI), the distribution of an intravenously applied colouring agent indocyanine green (ICG) can be analysed with the…”
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Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity by Schwedler, Christian, Häupl, Thomas, Kalus, Ulrich, Blanchard, Véronique, Burmester, Gerd-Rüdiger, Poddubnyy, Denis, Hoppe, Berthold

“…Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG…”
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Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing by Gaber, Timo, Brinkman, Antonia Clara Katharina, Pienczikowski, Justyna, Diesing, Karoline, Damerau, Alexandra, Pfeiffenberger, Moritz, Lang, Annemarie, Ohrndorf, Sarah, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Hoff, Paula

“…Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory…”
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A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients by Hoff, Paula, Gaber, Timo, Strehl, Cindy, Jakstadt, Manuela, Hoff, Holger, Schmidt-Bleek, Katharina, Lang, Annemarie, Röhner, Eric, Huscher, Dörte, Matziolis, Georg, Burmester, Gerd-Rüdiger, Schmidmaier, Gerhard, Perka, Carsten, Duda, Georg N, Buttgereit, Frank

“…Immunologically restricted patients such as those with autoimmune diseases or malignancies often suffer from delayed or insufficient fracture healing. In human…”
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