Search Results - "Rössler, Simon L."

Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands by Rössler, Simon L, Petrone, David A, Carreira, Erick M

“…Conspectus The catalytic, asymmetric synthesis of complex molecules has been a core focus of our research program for some time because developments in the…”
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Study of Intermediates in Iridium–(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution by Rössler, Simon L, Krautwald, Simon, Carreira, Erick M

“…Experimental mechanistic studies of iridium-catalyzed, enantioselective allylic substitution enabled by (phosphoramidite,olefin) ligands are reported…”
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Pyridinium Salts as Redox‐Active Functional Group Transfer Reagents by Rössler, Simon L., Jelier, Benson J., Magnier, Emmanuel, Dagousset, Guillaume, Carreira, Erick M., Togni, Antonio

“…In this Review, we highlight recent advances in the understanding and design of N‐functionalized pyridinium scaffolds as redox‐active, single‐electron,…”
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Pyridyl Radical Cation for C−H Amination of Arenes by Rössler, Simon L., Jelier, Benson J., Tripet, Pascal F., Shemet, Andrej, Jeschke, Gunnar, Togni, Antonio, Carreira, Erick M.

“…Electron‐transfer photocatalysis provides access to the elusive and unprecedented N‐pyridyl radical cation from selected N‐substituted pyridinium reagents. The…”
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Enantio- and Diastereoselective Spiroketalization Catalyzed by Chiral Iridium Complex by Hamilton, James Y, Rössler, Simon L, Carreira, Erick M

“…Iridium–(P,olefin) complex-catalyzed enantio- and diastereoselective formation of substituted spiroketals from racemic, allylic carbonates is reported, which…”
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Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations by Petrone, David A, Isomura, Mayuko, Franzoni, Ivan, Rössler, Simon L, Carreira, Erick M

“…An enantioconvergent C­(sp3)–C­(sp3) coupling between racemic allenylic electrophiles and alkylzinc reagents has been developed. An Ir/(phosphoramidite,olefin)…”
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Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis by Rössler, Simon L, Grob, Nathalie M, Buchwald, Stephen L, Pentelute, Bradley L

“…Encoding small-molecule information in DNA has been leveraged to accelerate the discovery of ligands for therapeutic targets such as proteins. However,…”
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Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium‐Catalyzed Asymmetric Allylic Alkylation by Sempere, Yeshua, Alfke, Jan L., Rössler, Simon L., Carreira, Erick M.

“…Morpholine ketene aminal is employed in iridium‐catalyzed asymmetric allylic alkylation reactions as a surrogate for amide enolates to prepare γ,δ‐unsaturated…”
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Total Synthesis and Stereochemical Assignment of (+)-Broussonetine H by Rössler, Simon L, Schreib, Benedikt S, Ginterseder, Matthias, Hamilton, James Y, Carreira, Erick M

“…Herein, the first total synthesis and stereochemical assignment of (+)-broussonetine H are reported. The ambiguous stereocenters within different fragments…”
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Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders by Grob, Nathalie M., Remarcik, Clint, Rössler, Simon L., Wong, Jeffrey Y. K., Wang, John C. K., Tao, Jason, Smith, Corey L., Loas, Andrei, Buchwald, Stephen L., Eaton, Dan L., López, Magdalena Preciado, Pentelute, Bradley L.

“…Protein–protein interactions (PPIs) are intriguing targets in drug discovery and development. Peptides are well suited to target PPIs, which typically present…”
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Enhanced Vaccine Immunogenicity Enabled by Targeted Cytosolic Delivery of Tumor Antigens into Dendritic Cells by Truex, Nicholas L., Rondon, Aurélie, Rössler, Simon L., Hanna, Cameron C., Cho, Yehlin, Wang, Bin-You, Backlund, Coralie M., Lutz, Emi A., Irvine, Darrell J., Pentelute, Bradley L.

“…Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of therapeutics that promote immunity against cancer and pathogenic…”
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Synthesis, Radiolabeling, and Biological Evaluation of 5‑Hydroxy-2‑[18F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging by Chiotellis, Aristeidis, Müller Herde, Adrienne, Rössler, Simon L, Brekalo, Ante, Gedeonova, Erika, Mu, Linjing, Keller, Claudia, Schibli, Roger, Krämer, Stefanie D, Ametamey, Simon M

“…Aiming at developing mechanism-based amino acid 18F-PET tracers for tumor imaging, we synthesized two 18F-labeled analogues of 5-hydroxy-l-[β-11C]­tryptophan…”
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Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium‐Catalyzed Asymmetric Allylic Alkylation by Sempere, Yeshua, Alfke, Jan L., Rössler, Simon L., Carreira, Erick M.

“…Morpholine ketene aminal is employed in iridium‐catalyzed asymmetric allylic alkylation reactions as a surrogate for amide enolates to prepare γ,δ‐unsaturated…”
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Pyridyl Radical Cation for C−H Amination of Arenes by Rössler, Simon L., Jelier, Benson J., Tripet, Pascal F., Shemet, Andrej, Jeschke, Gunnar, Togni, Antonio, Carreira, Erick M.

“…Electron‐transfer photocatalysis provides access to the elusive and unprecedented N‐pyridyl radical cation from selected N‐substituted pyridinium reagents. The…”
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Pyridiniumsalze als redoxaktive Reagenzien zur Übertragung funktioneller Gruppen by Rössler, Simon L., Jelier, Benson J., Magnier, Emmanuel, Dagousset, Guillaume, Carreira, Erick M., Togni, Antonio

“…In diesem Aufsatz sind die jüngsten Fortschritte beim Verständnis und Design von N‐funktionalisierten Pyridiniumsalzen als redoxaktivierte…”
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Pyridiniumsalze als redoxaktive Reagenzien zur Übertragung funktioneller Gruppen by Rössler, Simon L, Jelier, Benson J, Magnier, Emmanuel, Dagousset, Guillaume, Carreira, Erick M, Togni, Antonio

“…In diesem Aufsatz sind die jüngsten Fortschritte beim Verständnis und Design von N‐funktionalisierten Pyridiniumsalzen als redoxaktivierte…”
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