Search Results - "Rönn, T."

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion by Ling, C, Del Guerra, S, Lupi, R, Rönn, T, Granhall, C, Luthman, H, Masiello, P, Marchetti, P, Groop, L, Del Prato, S

“…Aims/hypothesis Insulin secretion in pancreatic islets is dependent upon mitochondrial function and production of ATP. The transcriptional coactivator…”
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Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle by Rönn, T, Poulsen, P, Hansson, O, Holmkvist, J, Almgren, P, Nilsson, P, Tuomi, T, Isomaa, B, Groop, L, Vaag, A, Ling, C

“…Aims/hypothesis Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes…”
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Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls by Ekman, C, Elgzyri, T, Ström, K, Almgren, P, Parikh, H, Dekker Nitert, Marloes, Rönn, T, Manderson Koivula, Fiona, Ling, C, Tornberg, Å B, Wollmer, P, Eriksson, K F, Groop, L, Hansson, O

“…Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for…”
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Unique splicing pattern of the TCF7L2 gene in human pancreatic islets by Osmark, P, Hansson, O, Jonsson, A, Rönn, T, Groop, L, Renström, E

“…Aims/hypothesis Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this…”
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Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia by Ahmad, S., Heraclides, A., Sun, Q., Elgzyri, T., Rönn, T., Ling, C., Isomaa, B., Eriksson, K.-F., Groop, L., Franks, P. W., Hansson, O.

“…Diabet. Med. 29, e377–e381 (2012) Aims  Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and…”
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Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets by Dayeh, T. A., Olsson, A. H., Volkov, P., Almgren, P., Rönn, T., Ling, C.

“…Aims/hypothesis To date, the molecular function of most of the reported type 2 diabetes-associated loci remains unknown. The introduction or removal of…”
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Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood by Rönn, Tina, Volkov, Petr, Gillberg, Linn, Kokosar, Milana, Perfilyev, Alexander, Jacobsen, Anna Louisa, Jørgensen, Sine W, Brøns, Charlotte, Jansson, Per-Anders, Eriksson, Karl-Fredrik, Pedersen, Oluf, Hansen, Torben, Groop, Leif, Stener-Victorin, Elisabet, Vaag, Allan, Nilsson, Emma, Ling, Charlotte

“…Increased age, BMI and HbA1c levels are risk factors for several non-communicable diseases. However, the impact of these factors on the genome-wide DNA…”
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Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6-month exercise intervention by Rönn, T., Volkov, P., Tornberg, Å., Elgzyri, T., Hansson, O., Eriksson, K.-F., Groop, L., Ling, C.

“…Aim Adipose tissue has an important function in total energy homeostasis, and its dysregulation may contribute to lifestyle‐related diseases such as type 2…”
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Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes by NILSSON, Emma, JANSSON, Per Anders, FADISTA, João, RONN, Tina, PEDERSEN, Bente Klarlund, SCHEELE, Camilla, VAAG, Allan, LING, Charlotte, PERFILYEV, Alexander, VOLKOV, Petr, PEDERSEN, Maria, SVENSSON, Maria K, POULSEN, Pemille, RIBEL-MADSEN, Rasmus, PEDERSEN, Nancy L, ALMGREN, Peter

“…Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying…”
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A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals by Rönn, T., Wen, J., Yang, Z., Lu, B., Du, Y., Groop, L., Hu, R., Ling, C.

“…Aims/hypothesis Recently, three groups independently reported that variation in MTNR1B , the gene encoding melatonin receptor 1B, was associated with an…”
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First-Degree Relatives of Type 2 Diabetic Patients Have Reduced Expression of Genes Involved in Fatty Acid Metabolism in Skeletal Muscle by Elgzyri, T, Parikh, H, Zhou, Y, Nitert, M. Dekker, Rönn, T, Segerström, Å. B, Ling, C, Franks, P. W, Wollmer, P, Eriksson, K. F, Groop, L, Hansson, O

“…Context: First-degree relatives of patients with type 2 diabetes (FH+) have been shown to have decreased energy expenditure and decreased expression of…”
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A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes by Koeck, Thomas, Olsson, Anders H., Nitert, Marloes Dekker, Sharoyko, Vladimir V., Ladenvall, Claes, Kotova, Olga, Reiling, Erwin, Rönn, Tina, Parikh, Hemang, Taneera, Jalal, Eriksson, Johan G., Metodiev, Metodi D., Larsson, Nils-Göran, Balhuizen, Alexander, Luthman, Holger, Stančáková, Alena, Kuusisto, Johanna, Laakso, Markku, Poulsen, Pernille, Vaag, Allan, Groop, Leif, Lyssenko, Valeriya, Mulder, Hindrik, Ling, Charlotte

“…Type 2 diabetes (T2D) evolves when insulin secretion fails. Insulin release from the pancreatic β cell is controlled by mitochondrial metabolism, which…”
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Expression of Phosphofructokinase in Skeletal Muscle Is Influenced by Genetic Variation and Associated With Insulin Sensitivity by KEILDSON, Sarah, FADISTA, Joao, BARRETT, Amy, NISBET, James, ZHENG, Hou-Feng, RÖNN, Tina, STRÖM, Kristoffer, ERIKSSON, Karl-Fredrik, PROKOPENKO, Inga, SPECTOR, Timothy D, DERMITZAKIS, Emmanouil T, DELOUKAS, Panos, LADENVALL, Claes, MCCARTHY, Mark I, RUNG, Johan, GROOP, Leif, FRANKS, Paul W, LINDGREN, Cecilia M, HANSSON, Ola, HEDMAN, Asa K, ELGZYRI, Targ, SMALL, Kerrin S, GRUNDBERG, Elin, NICA, Alexandra C, GLASS, Daniel, RICHARDS, J. Brent

“…Using an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally…”
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Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease by Rönn, Tina, Perfilyev, Alexander, Jönsson, Josefine, Eriksson, Karl-Fredrik, Jørgensen, Sine W, Brøns, Charlotte, Gillberg, Linn, Vaag, Allan, Stener-Victorin, Elisabet, Ling, Charlotte

“…Abstract Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous…”
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A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits by Volkov, Petr, Olsson, Anders H, Gillberg, Linn, Jørgensen, Sine W, Brøns, Charlotte, Eriksson, Karl-Fredrik, Groop, Leif, Jansson, Per-Anders, Nilsson, Emma, Rönn, Tina, Vaag, Allan, Ling, Charlotte

“…Little is known about the extent to which interactions between genetics and epigenetics may affect the risk of complex metabolic diseases and/or their…”
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Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets by Bacos, Karl, Perfilyev, Alexander, Karagiannopoulos, Alexandros, Cowan, Elaine, Ofori, Jones K, Bertonnier-Brouty, Ludivine, Rönn, Tina, Lindqvist, Andreas, Luan, Cheng, Ruhrmann, Sabrina, Ngara, Mtakai, Nilsson, Åsa, Gheibi, Sevda, Lyons, Claire L, Lagerstedt, Jens O, Barghouth, Mohammad, Esguerra, Jonathan Ls, Volkov, Petr, Fex, Malin, Mulder, Hindrik, Wierup, Nils, Krus, Ulrika, Artner, Isabella, Eliasson, Lena, Prasad, Rashmi B, Cataldo, Luis Rodrigo, Ling, Charlotte

“…Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we…”
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Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding by Gillberg, Linn, Perfilyev, Alexander, Brøns, Charlotte, Thomasen, Martin, Grunnet, Louise G., Volkov, Petr, Rosqvist, Fredrik, Iggman, David, Dahlman, Ingrid, Risérus, Ulf, Rönn, Tina, Nilsson, Emma, Vaag, Allan, Ling, Charlotte

“…Aims/hypothesis Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat…”
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Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms by Dankel, Simon N., Klocke, Bernward, Grallert, Harald, Glunk, Viktoria, Lee, Heekyoung, Ehlers, Kerstin, Wahl, Simone, Hoffmann, Christoph, Qian, Kun, Riess, Helene, Schroeder, Timm, Horsthemke, Bernhard, Voight, Benjamin F., Welch, Ryan P., Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S., McCulloch, Laura J., Ferreira, Teresa, Amin, Najaf, McCarroll, Steve A., Qi, Lu, Navarro, Pau, Ardlie, Kristin, Benediktsson, Rafn, Bennett, Amanda J., Boström, Kristina Bengtsson, Burtt, Noël P., Charpentier, Guillaume, Crawford, Gabe, Erdos, Michael R., Fox, Caroline S., Franklin, Christopher S., Gieger, Christian, Grarup, Niels, Griffin, Simon, Groves, Christopher J., Hadjadj, Samy, Johnson, Paul R.V., Klopp, Norman, Kong, Augustine, Kraft, Peter, Lauritzen, Torsten, Li, Man, Lyssenko, Valeriya, Marre, Michel, Morken, Mario A., Narisu, Narisu, Nilsson, Peter, Owen, Katharine R., Payne, Felicity, Perry, John R.B., Petersen, Ann-Kristin, Shields, Beverley M., Shrader, Peter, Sigurdsson, Gunnar, Strassburger, Klaus, Stringham, Heather M., Sun, Qi, Tichet, Jean, van Dam, Rob M., van Haeften, Timon W., van Herpt, Thijs, van Vliet-Ostaptchouk, Jana V., Weedon, Michael N., Wijmenga, Cisca, Bergman, Richard N., Cauchi, Stephane, Collins, Francis S., Gyllensten, Ulf, Hansen, Torben, Hitman, Graham A., Hofman, Albert, Laakso, Markku, Rudan, Igor, Stein, Lincoln D., Tuomilehto, Jaakko, Uitterlinden, Andre, Walker, Mark, Wareham, Nicholas J., Daly, Mark J., Hu, Frank B., Pankow, James S., Pedersen, Oluf, Florez, Jose C., Frayling, Timothy M., Groop, Leif, Wilson, James F., Illig, Thomas, van Duijn, Cornelia M., Stefansson, Kari, Boehnke, Michael, Spieler, Derek, Klingenspor, Martin, Dahlman, Ingrid, Hauck, Stefanie M., Blüher, Matthias, Hsu, Yi-Hsiang, Mellgren, Gunnar, Hauner, Hans

“…Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within…”
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Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes by Nilsson, E, Jansson, P, Perilyev, A, Pedersen, M, Svensson, MK, Poulsen, P, Ribel-Madsen, R, Pedersen, NL, Almgren, P, Fadista, J, Ronn, T, Klarlund-Pedersen, B, Scheele, C, Vaag, A, Ling, C

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Role of relational data base management system and client/server technology in EMS migration by Ahuja, G.S., Hart, R.T., Singh, J.

“…The databases and the data presentation software utilized by the control center computers (EMS) have always been highly specialized for the reason of the speed…”
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