Search Results - "Rödel, Claus"

Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years by Sauer, Rolf, Liersch, Torsten, Merkel, Susanne, Fietkau, Rainer, Hohenberger, Werner, Hess, Clemens, Becker, Heinz, Raab, Hans-Rudolf, Villanueva, Marie-Therese, Witzigmann, Helmut, Wittekind, Christian, Beissbarth, Tim, Rödel, Claus

“…Preoperative chemoradiotherapy (CRT) has been established as standard treatment for locally advanced rectal cancer after first results of the CAO/ARO/AIO-94…”
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Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO/ARO/AIO-94 trial by Fokas, Emmanouil, Liersch, Torsten, Fietkau, Rainer, Hohenberger, Werner, Beissbarth, Tim, Hess, Clemens, Becker, Heinz, Ghadimi, Michael, Mrak, Karl, Merkel, Susanne, Raab, Hans-Rudolf, Sauer, Rolf, Wittekind, Christian, Rödel, Claus

“…We previously described the prognostic impact of tumor regression grading (TRG) on the outcome of patients with rectal carcinoma treated with preoperative…”
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Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12 by Fokas, Emmanouil, Allgäuer, Michael, Polat, Bülent, Klautke, Gunther, Grabenbauer, Gerhard G, Fietkau, Rainer, Kuhnt, Thomas, Staib, Ludger, Brunner, Thomas, Grosu, Anca-Ligia, Schmiegel, Wolff, Jacobasch, Lutz, Weitz, Jürgen, Folprecht, Gunnar, Schlenska-Lange, Anke, Flentje, Michael, Germer, Christoph-Thomas, Grützmann, Robert, Schwarzbach, Matthias, Paolucci, Vittorio, Bechstein, Wolf O, Friede, Tim, Ghadimi, Michael, Hofheinz, Ralf-Dieter, Rödel, Claus

“…Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to…”
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Rectal cancer: Neoadjuvant chemoradiotherapy by Rödel, Claus, MD, Hofheinz, Ralf, MD, Fokas, Emmanouil, MD

“…Abstract The monolithic approach to apply the same schedule of preoperative 5-fluorouracil (5-FU)- or capecitabine-based chemoradiotherapy (CRT) to all…”
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Radiotherapy dose escalation does not improve local control in patients with esophageal cancer after definitive radiochemotherapy: the ARTDECO randomized phase III trial by Fokas, Emmanouil, Martin, Daniel, Rödel, Claus

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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer by Nicolas, Adele M., Pesic, Marina, Engel, Esther, Ziegler, Paul K., Diefenhardt, Markus, Kennel, Kilian B., Buettner, Florian, Conche, Claire, Petrocelli, Valentina, Elwakeel, Eiman, Weigert, Andreas, Zinoveva, Anna, Fleischmann, Maximilian, Häupl, Björn, Karakütük, Cem, Bohnenberger, Hanibal, Mosa, Mohammed H., Kaderali, Lars, Gaedcke, Jochen, Ghadimi, Michael, Rödel, Franz, Arkan, Melek C., Oellerich, Thomas, Rödel, Claus, Fokas, Emmanouil, Greten, Florian R.

“…Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal…”
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Critical Analysis of Bladder Sparing with Trimodal Therapy in Muscle-invasive Bladder Cancer: A Systematic Review by Ploussard, Guillaume, Daneshmand, Siamak, Efstathiou, Jason A, Herr, Harry W, James, Nicholas D, Rödel, Claus M, Shariat, Shahrokh F, Shipley, William U, Sternberg, Cora N, Thalmann, George N, Kassouf, Wassim

“…Abstract Context Aims of bladder preservation in muscle-invasive bladder cancer (MIBC) are to offer a quality-of-life advantage and avoid potential morbidity…”
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Outcome measures in multimodal rectal cancer trials by Fokas, Emmanouil, Glynne-Jones, Robert, Appelt, Ane, Beets-Tan, Regina, Beets, Geerard, Haustermans, Karin, Marijnen, Corrie, Minsky, Bruce D, Ludmir, Ethan, Quirke, Phil, Sebag-Montefiore, David, Garcia-Aguilar, Julio, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Buyse, Marc, Rödel, Claus

“…There is a large variability regarding the definition and choice of primary endpoints in phase 2 and phase 3 multimodal rectal cancer trials, resulting in…”
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Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial by Voss, Martin, Wenger, Katharina J., von Mettenheim, Nina, Bojunga, Jörg, Vetter, Manuela, Diehl, Bianca, Franz, Kea, Gerlach, Ruediger, Ronellenfitsch, Michael W., Harter, Patrick N., Hattingen, Elke, Steinbach, Joachim P., Rödel, Claus, Rieger, Johannes

“…Purpose The prospective, randomized ERGO2 trial investigated the effect of calorie-restricted ketogenic diet and intermittent fasting (KD-IF) on re-irradiation…”
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Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial by Rödel, Claus, Prof, Graeven, Ullrich, MD, Fietkau, Rainer, Prof, Hohenberger, Werner, Prof, Hothorn, Torsten, Prof, Arnold, Dirk, Prof, Hofheinz, Ralf-Dieter, Prof, Ghadimi, Michael, Prof, Wolff, Hendrik A, MD, Lang-Welzenbach, Marga, MSc, Raab, Hans-Rudolf, Prof, Wittekind, Christian, Prof, Ströbel, Philipp, Prof, Staib, Ludger, Prof, Wilhelm, Martin, Prof, Grabenbauer, Gerhard G, Prof, Hoffmanns, Hans, MD, Lindemann, Fritz, MD, Schlenska-Lange, Anke, MD, Folprecht, Gunnar, Prof, Sauer, Rolf, Prof, Liersch, Torsten, Prof

“…Summary Background Preoperative chemoradiotherapy with infusional fluorouracil, total mesorectal excision surgery, and postoperative chemotherapy with…”
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Tumor Regression Grading After Preoperative Chemoradiotherapy as a Prognostic Factor and Individual-Level Surrogate for Disease-Free Survival in Rectal Cancer by Fokas, Emmanouil, Ströbel, Philipp, Fietkau, Rainer, Ghadimi, Michael, Liersch, Torsten, Grabenbauer, Gerhard G, Hartmann, Arndt, Kaufmann, Marco, Sauer, Rolf, Graeven, Ullrich, Hoffmanns, Hans, Raab, Hans-Rudolf, Hothorn, Torsten, Wittekind, Christian, Rödel, Claus

“…We investigated tumor regression grading (TRG) as a prognostic marker and individual-level surrogate for disease-free survival (DFS) in patients with rectal…”
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Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer by RÖDEL, Franz, HOFFMANN, Jörg, DISTEL, Luitpold, HERRMANN, Martin, NOISTERNIG, Timmo, PAPADOPOULOS, Thomas, SAUER, Rolf, RÖDEL, Claus

“…Apoptosis levels have been shown to predict tumor response to preoperative radiochemotherapy in rectal cancer. Recently, the prominent role of survivin, a…”
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Image-guided high-dose-rate brachytherapy for rectal cancer: technical note and first clinical experience on an organ-preserving approach by Fleischmann, Maximilian, Diefenhardt, Markus, Trommel, Martin, Scherf, Christian, Ramm, Ulla, Chatzikonstantinou, Georgios, Fokas, Emmanouil, Rödel, Claus, Tselis, Nikolaos

“…Purpose As the population ages, the incidence of rectal cancer among elderly patients is rising. Due to the risk of perioperative morbidity and mortality,…”
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Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data by Maas, Monique, MD, Nelemans, Patty J, PhD, Valentini, Vincenzo, MD, Das, Prajnan, MD, Rödel, Claus, Prof, Kuo, Li-Jen, MD, Calvo, Felipe A, Prof, García-Aguilar, Julio, Prof, Glynne-Jones, Rob, PhD, Haustermans, Karin, Prof, Mohiuddin, Mohammed, MD, Pucciarelli, Salvatore, MD, Small, William, Prof, Suárez, Javier, MD, Theodoropoulos, George, PhD, Biondo, Sebastiano, MD, Beets-Tan, Regina GH, Prof, Beets, Geerard L, Dr

“…Summary Background Locally advanced rectal cancer is usually treated with preoperative chemoradiation. After chemoradiation and surgery, 15–27% of the patients…”
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Nomograms for Predicting Local Recurrence, Distant Metastases, and Overall Survival for Patients With Locally Advanced Rectal Cancer on the Basis of European Randomized Clinical Trials by VALENTINI, Vincenzo, VAN STIPHOUT, Ruud G. P. M, GERARD, Jean-Pierre, RÖDEL, Claus, SAINATO, Aldo, SAUER, Rolf, MINSKY, Bruce D, COLLETTE, Laurence, LAMBIN, Philippe, LAMMERING, Guido, GAMBACORTA, Maria Antonietta, BARBA, Maria Cristina, BEBENEK, Marek, BONNETAIN, Franck, BOSSET, Jean-Francois, BUJKO, Krzysztof, CIONINI, Luca

“…The purpose of this study was to develop accurate models and nomograms to predict local recurrence, distant metastases, and survival for patients with locally…”
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EURECCA colorectal: Multidisciplinary management: European consensus conference colon & rectum by van de Velde, Cornelis J.H, Boelens, Petra G, Borras, Josep M, Coebergh, Jan-Willem, Cervantes, Andres, Blomqvist, Lennart, Beets-Tan, Regina G.H, van den Broek, Colette B.M, Brown, Gina, Van Cutsem, Eric, Espin, Eloy, Haustermans, Karin, Glimelius, Bengt, Iversen, Lene H, van Krieken, J. Han, Marijnen, Corrie A.M, Henning, Geoffrey, Gore-Booth, Jola, Meldolesi, Elisa, Mroczkowski, Pawel, Nagtegaal, Iris, Naredi, Peter, Ortiz, Hector, Påhlman, Lars, Quirke, Philip, Rödel, Claus, Roth, Arnaud, Rutten, Harm, Schmoll, Hans J, Smith, Jason J, Tanis, Pieter J, Taylor, Claire, Wibe, Arne, Wiggers, Theo, Gambacorta, Maria A, Aristei, Cynthia, Valentini, Vincenzo

“…Abstract Background Care for patients with colon and rectal cancer has improved in the last 20 years; however considerable variation still exists in cancer…”
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Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial by Rödel, Claus, Prof, Liersch, Torsten, MD, Becker, Heinz, Prof, Fietkau, Rainer, Prof, Hohenberger, Werner, Prof, Hothorn, Torsten, Prof, Graeven, Ullrich, MD, Arnold, Dirk, Prof, Lang-Welzenbach, Marga, MSc, Raab, Hans-Rudolf, Prof, Sülberg, Heiko, MSc, Wittekind, Christian, Prof, Potapov, Sergej, MSc, Staib, Ludger, Prof, Hess, Clemens, Prof, Weigang-Köhler, Karin, MD, Grabenbauer, Gerhard G, Prof, Hoffmanns, Hans, MD, Lindemann, Fritz, MD, Schlenska-Lange, Anke, MD, Folprecht, Gunnar, MD, Sauer, Rolf, Prof

“…Summary Background Preoperative chemoradiotherapy, total mesorectal excision surgery, and adjuvant chemotherapy with fluorouracil is the standard combined…”
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Preoperative treatment of rectal cancer-Critical comments on the US-American PROSPECT trial by Fokas, Emmanouil, Rödel, Claus

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Impact of body-mass index on treatment and outcome in locally advanced rectal cancer: A secondary, post-hoc analysis of the CAO/ARO/AIO-04 randomized phase III trial by Diefenhardt, Markus, Ludmir, Ethan B., Hofheinz, Ralf-Dieter, Ghadimi, Michael, Minsky, Bruce D., Fleischmann, Max, Fokas, Emmanouil, Rödel, Claus

“…•Obesity was linked to a lower rate of sphincter preservation surgery in rectal cancer after neoadjuvant chemoradiotherapy.•Incidence of post-surgical…”
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C-Reactive Protein to Albumin Ratio as Prognostic Marker in Locally Advanced Non-Small Cell Lung Cancer Treated with Chemoradiotherapy by Frey, Alina, Martin, Daniel, D'Cruz, Louisa, Fokas, Emmanouil, Rödel, Claus, Fleischmann, Maximilian

“…Despite the implementation of consolidative immune checkpoint inhibition after definitive chemoradiotherapy (CRT), the prognosis for locally advanced…”
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