Search Results - "Rétey, János"

Friedel-Crafts-Type Mechanism for the Enzymatic Elimination of Ammonia from Histidine and Phenylalanine by Poppe, László, Rétey, János

“…The surprisingly high catalytic activity and selectivity of enzymes stem from their ability to both accelerate the target reaction and suppress competitive…”
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Discovery and role of methylidene imidazolone, a highly electrophilic prosthetic group by Rétey, János

“…The elimination of ammonia from α-amino acids is a chemically difficult process. While the non-acidic β-proton has to be abstracted, the much more acidic…”
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Investigation of the Mechanism of Action of Pyrogallol-Phloroglucinol Transhydroxylase by Using Putative Intermediates by Paizs, Csaba, Bartlewski-Hof, Ulrike, Rétey, János

“…Pyrogallol–phloroglucinol transhydroxylase from Pelobacter acidigallici, a molybdopterin‐containing enzyme, catalyzes a key reaction in the anaerobic…”
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Crystal Structure of Histidine Ammonia-Lyase Revealing a Novel Polypeptide Modification as the Catalytic Electrophile by Schwede, Torsten F, Rétey, János, Schulz, Georg E

“…Histidine ammonia-lyase (EC 4.3.1.3) catalyzes the nonoxidative elimination of the α-amino group of histidine and is closely related to the important plant…”
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Discovering New Enzymes and Metabolic Pathways:  Conversion of Succinate to Propionate by Escherichia coli by Haller, Toomas, Buckel, Thomas, Rétey, János, Gerlt, John A

“…The Escherichia coli genome encodes seven paralogues of the crotonase (enoyl CoA hydratase) superfamily. Four of these have unknown or uncertain functions;…”
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But-3-ene-1,2-diol: A Mechanism-Based Active Site Inhibitor for Coenzyme B₁₂-Dependent Glycerol Dehydratase by Pierik, Antonio J, Graf, Torsten, Pemberton, Louise, Golding, Bernard T, Rétey, János

“…Coenzyme B₁₂-dependent glycerol dehydratase is a radical enzyme that catalyses the conversion of glycerol into 3-hydroxypropanal and propane-1,2-diol into…”
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Inhibition of Histidine Ammonia Lyase by Heteroaryl-alanines and Acrylates by Katona, Adrian, Toşa, Monica Ioana, Paizs, Csaba, Rétey, János

“…Histidine ammonia lyase (HAL) catalyzes the elimination of ammonia from the substrate to form (E)‐urocanate. The interaction between HAL and acrylic acids or…”
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Mechanistic aspects of molybdenum-containing enzymes by Hille, Russ, Rétey, János, Bartlewski-Hof, Ulrike, Reichenbecher, Wolfram, Schink, Bernhard

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A Highly Convergent Synthesis of Myristoyl-carba(dethia)-coenzyme A by Tautz, Lutz, Rétey, Janos

“…Co‐translational myristoylation of the N‐terminal glycine residues of diverse signalling proteins is required for membrane attachment and proper function of…”
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Ethylmalonyl-CoA Mutase from Rhodobacter sphaeroides Defines a New Subclade of Coenzyme B12-dependent Acyl-CoA Mutases by Erb, Tobias J., Rétey, Janos, Fuchs, Georg, Alber, Birgit E.

“…Coenzyme B12-dependent mutases are radical enzymes that catalyze reversible carbon skeleton rearrangement reactions. Here we describe Rhodobacter sphaeroides…”
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Mimicking the Reaction of Phenylalanine Ammonia Lyase by a Synthetic Model by Rettig, Martin, Sigrist, Andreas, Rétey, János

“…Phenylalanine and histidine ammonia lyases (PAL and HAL) catalyze the reversible conversion of α‐amino acids to the corresponding acrylic acids by elimination…”
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Serine-202 is the putative precursor of the active site dehydroalanine of phenylalanine ammonia lyase Site-directed mutagenesis studies on the enzyme from parsley ( Petroselinum crispum L.) by Schuster, Birgid, Rétey, János

“…To investigate the possible role of serine as a precursor of dehydroalanine at the active site of phenylalanine ammonia lyase, two serines, conserved in all…”
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The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine by Schuster, B, Rétey, J

“…Phenylalanine ammonia-lyase (EC 4.3.1.5) from parsley is posttranslationally modified by dehydrating its Ser-202 to the catalytically essential dehydroalanine…”
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An active site homology model of phenylalanine ammonia‐lyase from P. crispum by Röther, Dagmar, Poppe, László, Morlock, Gaby, Viergutz, Sandra, Rétey, János

“…The plant enzyme phenylalanine ammonia‐lyase (PAL, EC 4.3.1.5) shows homology to histidine ammonia‐lyase (HAL) whose structure has been solved by X‐ray…”
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The Interaction of Heteroaryl-Acrylates and Alanines with Phenylalanine Ammonia-Lyase from Parsley by Paizs, Csaba, Katona, Adrian, Rétey, János

“…Acrylic acids and alanines substituted with heteroaryl groups at the β‐position were synthesized and spectroscopically characterized (UV, HRMS, 1H NMR, and 13C…”
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Further Insights into the Mechanism of Action of Methylmalonyl‐CoA Mutase by Electron Paramagnetic Resonance Studies by Abend, Andreas, Illich, Valentin, Rétey, Jànos

“…Novel analogues of methylmalonyl‐CoA and succinyl‐CoA have been prepared and used for mechanistic investigations on the coenzyme‐B12‐dependent…”
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Ethanolamine Ammonia-Lyase Has a “Base-On” Binding Mode for Coenzyme B12 by Abend, Andreas, Bandarian, Vahe, Nitsche, Rainer, Stupperich, Erhard, Rétey, Janos, Reed, George H.

“…Ethanolamine ammonia-lyase (EAL, EC 4.3.1.7) catalyzes a coenzyme B12-dependent deamination of vicinal amino alcohols. The mode of binding of coenzyme B12 to…”
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Chemoenzymatic One-Pot Synthesis of Enantiopure L-Arylalanines from Arylaldehydes by Paizs, Csaba, Katona, Adrian, Rétey, János

“…Various enantiopure L‐arylalanines can be prepared from the corresponding arylaldehydes in one‐pot fashion by a combination of chemical and enzymatic…”
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The putative coenzyme B12-dependent methylmalonyl-CoA mutase from potatoes is a phosphatase by Paizs, Csaba, Diemer, Tanja, Rétey, János

“…The reported presence of a coenzyme B12-dependent methylmalonyl-CoA mutase in potatoes has been reexamined. The enzyme converting methylmalonyl-CoA was…”
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1,4-Dihydro-[formula omitted]-phenylalanine—Its Synthesis and Behavior in the Phenylalanine Ammonia–Lyase Reaction by Skolaut, Alexander, Rétey, János

“…1,4-Dihydro-l-phenylalanine, a nonaromatic derivative of l-phenylalanine, has been isolated for the first time. It was synthesized as a yet unobserved minor…”
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