Search Results - "RÜCKER, G."

New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise by Bohl, Stephan R, Bullinger, Lars, Rücker, Frank G

“…The therapeutic approach for acute myeloid leukemia (AML) remains challenging, since over the last four decades a stagnation in standard cytotoxic treatment…”
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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta‐analysis by Weibel, S., Schaefer, M. S., Raj, D., Rücker, G., Pace, N. L., Schlesinger, T., Meybohm, P., Kienbaum, P., Eberhart, L. H. J., Kranke, P.

“…Summary Postoperative nausea and vomiting is a common adverse effect of anaesthesia. Although dozens of different anti‐emetics are available for clinical…”
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Differences in the placebo response between trials do not necessarily preclude network meta‐analysis by Rücker, G., Schwarzer, G.

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Low‐dose aspirin for secondary cardiovascular prevention – cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation – review and meta‐analysis by BURGER, W., CHEMNITIUS, J.‐M., KNEISSL, G. D., RÜCKER, G.

“… Objectives.  Low‐dose aspirin given for secondary prevention of cardiovascular disease is frequently withdrawn prior to surgical or diagnostic procedures to…”
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Clinical implications of subclonal TP53 mutations in acute myeloid leukemia by Prochazka, Katharina T, Pregartner, Gudrun, Rücker, Frank G, Heitzer, Ellen, Pabst, Gabriel, Wölfler, Albert, Zebisch, Armin, Berghold, Andrea, Döhner, Konstanze, Sill, Heinz

“…The role of subclonal mutations, defined by a variant allele frequency of <20%, has not been addressed in acute myeloid leukemia yet. We, therefore, analyzed…”
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Impact of investigator initiated trials and industry sponsored trials on medical practice (IMPACT): rationale and study design by Nury, E, Bischoff, K, Wollmann, K, Nitschke, K, Lohner, S, Schumacher, M, Rücker, G, Blümle, A

“…The German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) initiated large research programs to foster high quality…”
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Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia by Krönke, Jan, Bullinger, Lars, Teleanu, Veronica, Tschürtz, Florian, Gaidzik, Verena I., Kühn, Michael W.M., Rücker, Frank G., Holzmann, Karlheinz, Paschka, Peter, Kapp-Schwörer, Silke, Späth, Daniela, Kindler, Thomas, Schittenhelm, Marcus, Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

“…Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal…”
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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations by Döhner, Konstanze, Schlenk, Richard F., Habdank, Marianne, Scholl, Claudia, Rücker, Frank G., Corbacioglu, Andrea, Bullinger, Lars, Fröhling, Stefan, Döhner, Hartmut

“…To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic shuttle protein in younger adults with acute myeloid leukemia…”
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Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype by Rücker, Frank G, Dolnik, Anna, Blätte, Tamara J, Teleanu, Veronica, Ernst, Aurélie, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze, Bullinger, Lars

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Biomass burning fuel consumption rates: a field measurement database by van Leeuwen, T. T, van der Werf, G. R, Hoffmann, A. A, Detmers, R. G, Rücker, G, French, N. H. F, Archibald, S, Carvalho Jr., J. A, Cook, G. D, de Groot, W. J, Hély, C, Kasischke, E. S, Kloster, S, McCarty, J. L, Pettinari, M. L, Savadogo, P, Alvarado, E. C, Boschetti, L, Manuri, S, Meyer, C. P, Siegert, F, Trollope, L. A, Trollope, W. S. W

“…Landscape fires show large variability in the amount of biomass or fuel consumed per unit area burned. Fuel consumption (FC) depends on the biomass available…”
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The role of routine SARS-CoV-2 screening of healthcare-workers in acute care hospitals in 2020: a systematic review and meta-analysis by Jabs, J M, Schwabe, A, Wollkopf, A D, Gebel, B, Stadelmaier, J, Erdmann, S, Radicke, F, Grundmann, H, Kramer, A, Monsef, I, Rücker, G, Rupp, J, Scheithauer, S, Schmucker, C, Simon, A, Mutters, Nico T

“…Healthcare workers (HCW) are at increased risk of infection with SARS-CoV-2. Vulnerable patient populations in particular must be protected, and clinics should…”
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Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia by Lal, Ridhima, Lind, Karin, Heitzer, Ellen, Ulz, Peter, Aubell, Kristina, Kashofer, Karl, Middeke, Jan M., Thiede, Christian, Schulz, Eduard, Rosenberger, Angelika, Hofer, Sybille, Feilhauer, Birgit, Rinner, Beate, Svendova, Vendula, Schimek, Michael G., Rücker, Frank G., Hoefler, Gerald, Döhner, Konstanze, Zebisch, Armin, Wölfler, Albert, Sill, Heinz

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The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements by Grasedieck, Sarah, Cabantog, Ariene, MacPhee, Liam, Im, Junbum, Ruess, Christoph, Demir, Burcu, Sperb, Nadine, Rücker, Frank G., Döhner, Konstanze, Herold, Tobias, Pollack, Jonathan R., Bullinger, Lars, Rouhi, Arefeh, Kuchenbauer, Florian

“…Aberrant expression of Ecotropic Viral Integration Site 1 (EVI1) is a hallmark of acute myeloid leukemia (AML) with inv(3) or t(3;3), which is a disease…”
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Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing by Dolnik, Anna, Engelmann, Julia C., Scharfenberger-Schmeer, Maren, Mauch, Julian, Kelkenberg-Schade, Sabine, Haldemann, Berit, Fries, Tamara, Krönke, Jan, Kühn, Michael W.M., Paschka, Peter, Kayser, Sabine, Wolf, Stephan, Gaidzik, Verena I., Schlenk, Richard F., Rücker, Frank G., Döhner, Hartmut, Lottaz, Claudio, Döhner, Konstanze, Bullinger, Lars

“…Acute myeloid leukemia (AML) is characterized by molecular heterogeneity. As commonly altered genomic regions point to candidate genes involved in…”
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Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia by Russ, A. C., Sander, S., Luck, S. C., Lang, K. M., Bauer, M., Rucker, F. G., Kestler, H. A., Schlenk, R. F., Dohner, H., Holzmann, K., Dohner, K., Bullinger, L.

“…MicroRNAs are regulators of gene expression, which act mainly by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been…”
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Biopsy-derived oral keratinocytes – A model to potentially test for oral mucosa radiation sensitivity by Thomsen, A.R., Aldrian, C., Luka, B., Hornhardt, S., Huber, K., Gomolka, M., Moertl, S., Hess, J., Zitzelsberger, H., Heider, T., Schlueter, N., Rau, S., Monroy Ordonez, B., Schäfer, H., Rücker, G., Henke, M.

“…•Human oral keratinocytes – the key players in radiation mucositis in head and neck cancer treatment – are established ex vivo from patient-derived…”
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Disclosure of Candidate Genes in Acute Myeloid Leukemia With Complex Karyotypes Using Microarray-Based Molecular Characterization by RÜCKER, Frank G, BULLINGER, Lars, RADLWIMMER, Bernhard, KESTLER, Hans A, POLLACK, Jonathan R, LICHTER, Peter, DOHNER, Konstanze, DÖHNER, Hartmut, SCHWAENEN, Carsten, LIPKA, Daniel B, WESSENDORF, Swen, FRÖHLING, Stefan, BENTZ, Martin, MILLER, Simone, SCHOLL, Claudia, SCHLENK, Richard F

“…To identify novel genomic regions of interest in acute myeloid leukemia (AML) with complex karyotypes, we applied comparative genomic hybridization to…”
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Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia by Bullinger, Lars, Rücker, Frank G., Kurz, Stephan, Du, Juan, Scholl, Claudia, Sander, Sandrine, Corbacioglu, Andrea, Lottaz, Claudio, Krauter, Jürgen, Fröhling, Stefan, Ganser, Arnold, Schlenk, Richard F., Döhner, Konstanze, Pollack, Jonathan R., Döhner, Hartmut

“…Core binding factor (CBF) leukemias, characterized by either inv(16)/t(16;16) or t(8;21), constitute acute myeloid leukemia (AML) subgroups with favorable…”
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Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib by Schultheiss, Markus, Rücker, Frank G., Möller, Peter, Bullinger, Lars, Barth, Thomas F. E., von Baer, Alexandra, Wittau, Mathias, Brüderlein, Silke, von Witzleben, Adrian, Mellert, Kevin, Jäger, Daniela, Marienfeld, Ralf, Böhm, Michael J., Mayer-Steinacker, Regine

“…Leiomyosarcoma (LMS) is characterized by high genomic complexity, and to date, no specific targeted therapy is available. In a genome-wide approach, we…”
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Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair by Herzig, Julia K, Bullinger, Lars, Tasdogan, Alpaslan, Zimmermann, Philipp, Schlegel, Martin, Teleanu, Veronica, Weber, Daniela, Rücker, Frank G, Paschka, Peter, Dolnik, Anna, Schneider, Edith, Kuchenbauer, Florian, Heidel, Florian H, Buske, Christian, Döhner, Hartmut, Döhner, Konstanze, Gaidzik, Verena I

“…We have previously identified a recurrent deletion at chromosomal band 3p14.1-p13 in patients with acute myeloid leukemia (AML). Among eight protein-coding…”
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