Search Results - "RÖNN, Tina"

Epigenetics in Human Obesity and Type 2 Diabetes by Ling, Charlotte, Rönn, Tina

“…Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated…”
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Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine? by Ling, Charlotte, Bacos, Karl, Rönn, Tina

“…Pioneering studies performed over the past few decades demonstrate links between epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with…”
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Epigenetic adaptation to regular exercise in humans by Ling, Charlotte, Rönn, Tina

“…•Exercise alters the gene expression pattern in multiple tissues.•Regular exercise can modify the genome-wide DNA methylation pattern in humans.•Regular…”
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DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes by Rönn, Tina, Ling, Charlotte

“…Type 2 diabetes (T2D) develops due to insulin resistance and impaired insulin secretion, predominantly in genetically predisposed subjects exposed to…”
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Predicting type 2 diabetes via machine learning integration of multiple omics from human pancreatic islets by Rönn, Tina, Perfilyev, Alexander, Oskolkov, Nikolay, Ling, Charlotte

“…Type 2 diabetes (T2D) is the fastest growing non-infectious disease worldwide. Impaired insulin secretion from pancreatic beta-cells is a hallmark of T2D, but…”
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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion by Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H, Kirkpatrick, Clare L, Wollheim, Claes B, Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte

“…Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic…”
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Epigenetic markers to further understand insulin resistance by Ling, Charlotte, Rönn, Tina

“…Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its related risk factors including age and obesity. Insulin resistance, a…”
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A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue by Rönn, Tina, Volkov, Petr, Davegårdh, Cajsa, Dayeh, Tasnim, Hall, Elin, Olsson, Anders H, Nilsson, Emma, Tornberg, Asa, Dekker Nitert, Marloes, Eriksson, Karl-Fredrik, Jones, Helena A, Groop, Leif, Ling, Charlotte

“…Epigenetic mechanisms are implicated in gene regulation and the development of different diseases. The epigenome differs between cell types and has until now…”
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ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes by Bysani, Madhusudhan, Agren, Rasmus, Davegårdh, Cajsa, Volkov, Petr, Rönn, Tina, Unneberg, Per, Bacos, Karl, Ling, Charlotte

“…Impaired insulin secretion from pancreatic islets is a hallmark of type 2 diabetes (T2D). Altered chromatin structure may contribute to the disease. We…”
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Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets by Olsson, Anders H, Volkov, Petr, Bacos, Karl, Dayeh, Tasnim, Hall, Elin, Nilsson, Emma A, Ladenvall, Claes, Rönn, Tina, Ling, Charlotte

“…Genetic and epigenetic mechanisms may interact and together affect biological processes and disease development. However, most previous studies have…”
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Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner by Brøns, Charlotte, Jacobsen, Stine, Nilsson, Emma, Rönn, Tina, Jensen, Christine B., Storgaard, Heidi, Poulsen, Pernille, Groop, Leif, Ling, Charlotte, Astrup, Arne, Vaag, Allan

“…Context: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic…”
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Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets by Hall, Elin, Volkov, Petr, Dayeh, Tasnim, Bacos, Karl, Rönn, Tina, Nitert, Marloes Dekker, Ling, Charlotte

“…Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated…”
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Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy by Agardh, Elisabet, Lundstig, Annika, Perfilyev, Alexander, Volkov, Petr, Freiburghaus, Tove, Lindholm, Eero, Rönn, Tina, Agardh, Carl-David, Ling, Charlotte

“…Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with…”
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Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes by Rönn, Tina, Ofori, Jones K., Perfilyev, Alexander, Hamilton, Alexander, Pircs, Karolina, Eichelmann, Fabian, Garcia-Calzon, Sonia, Karagiannopoulos, Alexandros, Stenlund, Hans, Wendt, Anna, Volkov, Petr, Schulze, Matthias B., Mulder, Hindrik, Eliasson, Lena, Ruhrmann, Sabrina, Bacos, Karl, Ling, Charlotte

“…Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion…”
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Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis by Volkov, Petr, Bacos, Karl, Ofori, Jones K, Esguerra, Jonathan Lou S, Eliasson, Lena, Rönn, Tina, Ling, Charlotte

“…Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited. Only a few studies have investigated DNA methylation of selected…”
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Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes by DEKKER NITERT, Marloes, DAYEH, Tasnim, WEISHAUPT, Holger, ATTEMA, Joanne, ABELS, Mia, WIERUP, Nils, ALMGREN, Peter, JANSSON, Per-Anders, RÖNN, Tina, HANSSON, Ola, ERIKSSON, Karl-Fredrik, GROOP, Leif, VOLKOV, Peter, LING, Charlotte, ELGZYRI, Targ, HALL, Elin, NILSSON, Emma, YANG, Beatrice T, LANG, Stefan, PARIKH, Hemang, WESSMAN, Ylva

“…To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation…”
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A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits by Volkov, Petr, Olsson, Anders H, Gillberg, Linn, Jørgensen, Sine W, Brøns, Charlotte, Eriksson, Karl-Fredrik, Groop, Leif, Jansson, Per-Anders, Nilsson, Emma, Rönn, Tina, Vaag, Allan, Ling, Charlotte

“…Little is known about the extent to which interactions between genetics and epigenetics may affect the risk of complex metabolic diseases and/or their…”
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Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes by Ouni, Meriem, Saussenthaler, Sophie, Eichelmann, Fabian, Jähnert, Markus, Stadion, Mandy, Wittenbecher, Clemens, Rönn, Tina, Zellner, Lisa, Gottmann, Pascal, Ling, Charlotte, Schulze, Matthias B, Schürmann, Annette

“…The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention. Here, we used a translational approach…”
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Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes by NILSSON, Emma, JANSSON, Per Anders, FADISTA, João, RONN, Tina, PEDERSEN, Bente Klarlund, SCHEELE, Camilla, VAAG, Allan, LING, Charlotte, PERFILYEV, Alexander, VOLKOV, Petr, PEDERSEN, Maria, SVENSSON, Maria K, POULSEN, Pemille, RIBEL-MADSEN, Rasmus, PEDERSEN, Nancy L, ALMGREN, Peter

“…Genetics, epigenetics, and environment may together affect the susceptibility for type 2 diabetes (T2D). Our aim was to dissect molecular mechanisms underlying…”
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Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets by Hall, Elin, Volkov, Petr, Dayeh, Tasnim, Esguerra, Jonathan Lou S, Salö, Sofia, Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte

“…Epigenetic factors regulate tissue-specific expression and X-chromosome inactivation. Previous studies have identified epigenetic differences between sexes in…”
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