Search Results - "Qvist, Per"

Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients by Kragstrup, Tue W, Singh, Helene Søgaard, Grundberg, Ida, Nielsen, Ane Langkilde-Lauesen, Rivellese, Felice, Mehta, Arnav, Goldberg, Marcia B, Filbin, Michael R, Qvist, Per, Bibby, Bo Martin

“…Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin converting enzyme 2 (ACE2) enabling entrance of the virus into cells and…”
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Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq by Rajkumar, Anto P, Qvist, Per, Lazarus, Ross, Lescai, Francesco, Ju, Jia, Nyegaard, Mette, Mors, Ole, Børglum, Anders D, Li, Qibin, Christensen, Jane H

“…Massively parallel cDNA sequencing (RNA-seq) experiments are gradually superseding microarrays in quantitative gene expression profiling. However, many…”
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Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration by Habekost, Mette, Qvist, Per, Denham, Mark, Holm, Ida E., Jørgensen, Arne Lund

“…Neurons produced by reprogramming of other cell types are used to study cellular mechanisms of age-related neurodegenerative diseases. To model Alzheimer’s…”
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Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells by Maimaitili, Muyesier, Chen, Muwan, Febbraro, Fabia, Ucuncu, Ekin, Kelly, Rachel, Niclis, Jonathan Christos, Christiansen, Josefine Rågård, Mermet-Joret, Noëmie, Niculescu, Dragos, Lauritsen, Johanne, Iannielli, Angelo, Klæstrup, Ida H., Jensen, Uffe Birk, Qvist, Per, Nabavi, Sadegh, Broccoli, Vania, Nykjær, Anders, Romero-Ramos, Marina, Denham, Mark

“…Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts containing only…”
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MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons by Habekost, Mette, Jørgensen, Arne Lund, Qvist, Per, Denham, Mark

“…•Combined actions of miR-9/9*-124 and Ascl1 convert porcine fibroblasts into neurons.•Porcine induced neurons express common mature, glutamatergic and…”
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Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping by Paternoster, Veerle, Edhager, Anders Valdemar, Qvist, Per, Donskov, Julie Grinderslev, Shliaha, Pavel, Jensen, Ole Nørregaard, Mors, Ole, Nielsen, Anders Lade, Børglum, Anders Dupont, Palmfeldt, Johan, Christensen, Jane Hvarregaard

“…Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1 , is involved in determining mental health, and the importance of the BRD1…”
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CtIP Mutations Cause Seckel and Jawad Syndromes by Qvist, Per, Huertas, Pablo, Jimeno, Sonia, Nyegaard, Mette, Hassan, Muhammad J, Jackson, Stephen P, Børglum, Anders D

“…Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. Genetically, it constitutes a…”
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SorCS2 binds progranulin to regulate motor neuron development by Thomasen, Pernille Bogetofte, Salasova, Alena, Kjaer-Sorensen, Kasper, Woloszczuková, Lucie, Lavický, Josef, Login, Hande, Tranberg-Jensen, Jeppe, Almeida, Sergio, Beel, Sander, Kavková, Michaela, Qvist, Per, Kjolby, Mads, Ovesen, Peter Lund, Nolte, Stella, Vestergaard, Benedicte, Udrea, Andreea-Cornelia, Nejsum, Lene Niemann, Chao, Moses V., Van Damme, Philip, Krivanek, Jan, Dasen, Jeremy, Oxvig, Claus, Nykjaer, Anders

“…Motor neuron (MN) development and nerve regeneration requires orchestrated action of a vast number of molecules. Here, we identify SorCS2 as a progranulin…”
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Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk by Paternoster, Veerle, Svanborg, Maria, Edhager, Anders Valdemar, Rajkumar, Anto P., Eickhardt, Esben Ahlburg, Pallesen, Jonatan, Grove, Jakob, Qvist, Per, Fryland, Tue, Wegener, Gregers, Nyengaard, Jens Randel, Mors, Ole, Palmfeldt, Johan, Børglum, Anders Dupont, Christensen, Jane Hvarregaard

“…Genetic and molecular studies have implicated the Bromodomain containing 1 (BRD1) gene in the pathogenesis of schizophrenia and bipolar disorder. Accordingly,…”
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Transcriptomic profiling of porcine pluripotency identifies species-specific reprogramming requirements for culturing iPSCs by Habekost, Mette, Jørgensen, Arne Lund, Qvist, Per, Denham, Mark

“…•Transcriptomic profiling of porcine, murine and human stem cells was performed.•Porcine embryonic stem cell (ESC) transcriptome resembles naïve-state human…”
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The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation by Paternoster, Veerle, Cömert, Cagla, Kirk, Louise Sand, la Cour, Sanne Hage, Fryland, Tue, Fernandez-Guerra, Paula, Stougaard, Magnus, Nyengaard, Jens Randel, Qvist, Per, Bross, Peter, Børglum, Anders Dupont, Christensen, Jane Hvarregaard

“…Bromodomain containing 1 ( BRD1) encodes an epigenetic regulator that controls the expression of genetic networks linked to mental illness. BRD1 is essential…”
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SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells by Kalnytska, Oleksandra, Qvist, Per, Kunz, Séverine, Conrad, Thomas, Willnow, Thomas E., Schmidt, Vanessa

“…Sorting receptor SORCS2 is a stress-response factor protecting neurons from acute insults, such as during epilepsy. SORCS2 is also expressed in the pancreas,…”
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DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele by Dyrvig, Mads, Qvist, Per, Lichota, Jacek, Larsen, Knud, Nyegaard, Mette, Børglum, Anders D, Christensen, Jane H

“…The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying…”
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Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities by Karsdal, Morten A, Woodworth, Thasia, Henriksen, Kim, Maksymowych, Walter P, Genant, Harry, Vergnaud, Philippe, Christiansen, Claus, Schubert, Tanja, Qvist, Per, Schett, Georg, Platt, Adam, Bay-Jensen, Anne-Christine

“…Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal…”
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Neuropsin in mental health by Bukowski, Lina, Chernomorchenko, Ana M F, Starnawska, Anna, Mors, Ole, Staunstrup, Nicklas H, Børglum, Anders D, Qvist, Per

“…Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic…”
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Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice by Rajkumar, Anto P., Qvist, Per, Donskov, Julie G., Lazarus, Ross, Pallesen, Jonatan, Nava, Nicoletta, Winther, Gudrun, Liebenberg, Nico, Cour, Sanne H. la, Paternoster, Veerle, Fryland, Tue, Palmfeldt, Johan, Fejgin, Kim, Mørk, Arne, Nyegaard, Mette, Pakkenberg, Bente, Didriksen, Michael, Nyengaard, Jens R., Wegener, Gregers, Mors, Ole, Christensen, Jane H., Børglum, Anders D.

“…The schizophrenia-associated gene, BRD1 , encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health…”
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Abnormal Amyloid Load in Mild Cognitive Impairment: The Effect of Reducing the PiB‐PET Threshold by Ismail, Rola, Parbo, Peter, Hansen, Kim V., Schaldemose, Jeppe L., Dalby, Rikke B., Tietze, Anna, Kjeldsen, Pernille L., Cour, Sanne Hage, Qvist, Per, Gottrup, Hanne, Eskildsen, Simon F., Brooks, David J.

“…ABSTRACT BACKGROUND AND PURPOSE In vivo detection of β‐amyloid (Aβ) plaques in Alzheimer's disease (AD) is now possible with 11C‐PiB positron emission…”
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Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis by Veidal, Sanne S., Vassiliadis, Efstathios, Barascuk, Natasha, Zhang, Chen, Segovia-Silvestre, Toni, Klickstein, Lloyd, Larsen, Martin R., Qvist, Per, Christiansen, Claus, Vainer, Ben, Karsdal, Morten A.

“…Background: During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen…”
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Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells by Björkman, Andrea, Qvist, Per, Du, Likun, Bartish, Margarita, Zaravinos, Apostolos, Georgiou, Konstantinos, Børglum, Anders D., Gatti, Richard A., Törngren, Therese, Pan-Hammarström, Qiang

“…Breast cancer type 1 susceptibility protein (BRCA1) has a multitude of functions that contribute to genome integrity and tumor suppression. Its participation…”
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The Relative Use of Eight Collagenous and Noncollagenous Markers for Diagnosis of Skeletal Metastases in Breast, Prostate, or Lung Cancer Patients by Leeming, Diana J, Koizumi, Mitsuru, Byrjalsen, Inger, Li, Bo, Qvist, Per, Tankó, László B

“…The present study was sought to assess the relative use of eight biomarkers for the detection of bone metastases in cancer forms frequently spreading to the…”
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