Search Results - "Qusa, Mohammed"

Novel olive oil phenolic (−)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities by Qusa, Mohammed H., Siddique, Abu Bakar, Nazzal, Sami, El Sayed, Khalid A.

“…[Display omitted] •Oleocanthal is exclusive olive oil phenolic recurrence inhibitor.•Oleocanthal was stable at xylitol-based solid dispersion…”
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S -(-)-Oleocanthal Ex Vivo Modulatory Effects on Gut Microbiota by Qusa, Mohammed H, Abdelwahed, Khaldoun S, Hill, Ronald A, El Sayed, Khalid A

“…Compelling evidence points to the critical role of bioactive extra-virgin olive oil (EVOO) phenolics and gut microbiota (GM) interplay, but reliable models for…”
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Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor by Abdelwahed, Khaldoun S., Siddique, Abu Bakar, Mohyeldin, Mohamed M., Qusa, Mohammed H., Goda, Amira A., Singh, Sitanshu S., Ayoub, Nehad M., King, Judy Ann, Jois, Seetharama D., El Sayed, Khalid A.

“…[Display omitted] Hypercholesterolemia has been documented to drive hormone-dependent breast cancer (BC) progression and resistance to hormonal therapy…”
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Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity by Siddique, Abu Bakar, Ebrahim, Hassan, Mohyeldin, Mohamed, Qusa, Mohammed, Batarseh, Yazan, Fayyad, Ahmed, Tajmim, Afsana, Nazzal, Sami, Kaddoumi, Amal, El Sayed, Khalid

“…Epidemiological and clinical studies compellingly documented the ability of Mediterranean diet rich in extra-virgin olive oil (EVOO) to reduce breast and colon…”
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Comparative Gene Signature of (-)-Oleocanthal Formulation Treatments in Heterogeneous Triple Negative Breast Tumor Models: Oncological Therapeutic Target Insights by Qusa, Mohammed H, Abdelwahed, Khaldoun S, Siddique, Abu Bakar, El Sayed, Khalid A

“…Triple negative breast cancer (TNBC) heterogeneity and limited therapeutic options confer its phenotypic aggressiveness. The discovery of anti-TNBC natural…”
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Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation by Abdelwahed, Khaldoun S, Siddique, Abu Bakar, Ebrahim, Hassan Y, Qusa, Mohammed H, Mudhish, Ethar A, Rad, Ashkan H, Zerfaoui, Mourad, Abd Elmageed, Zakaria Y, El Sayed, Khalid A

“…Metastatic castration-resistant prostate cancer (mCRPC) cells can de novo biosynthesize their own cholesterol and overexpress proprotein convertase…”
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(-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model by Tajmim, Afsana, Cuevas-Ocampo, Areli K, Siddique, Abu Bakar, Qusa, Mohammed H, King, Judy Ann, Abdelwahed, Khaldoun S, Sonju, Jafrin Jobayer, El Sayed, Khalid A

“…Alzheimer’s disease (AD) is a complex progressive neurodegenerative disorder affecting humans mainly through the deposition of Aβ-amyloid (Aβ) fibrils and…”
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Olive Oil Lignan (+)-Acetoxypinoresinol Peripheral Motor and Neuronal Protection against the Tremorgenic Mycotoxin Penitrem A Toxicity via STAT1 Pathway by Qusa, Mohammed H, Abdelwahed, Khaldoun S, Meyer, Sharon A, El Sayed, Khalid A

“…Penitrem A, PA, is an indole diterpene alkaloid produced by several fungal species. PA acts as a selective Ca2+-dependent K-channels (Maxi-K, BK) antagonist in…”
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PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead by Abdelwahed, Khaldoun S, Siddique, Abu Bakar, Qusa, Mohammed H, King, Judy Ann, Souid, Soumaya, Abd Elmageed, Zakaria Y, El Sayed, Khalid A

“…Prostate cancer (PC) is the most common malignancy and the second leading cause of cancer death in men. Proprotein convertase subtilisin/kexin type 9 (PCSK9)…”
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Spontaneous In Vitro and In Vivo Interaction of (−)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers by Darakjian, Lucy I, Rigakou, Aimilia, Brannen, Andrew, Qusa, Mohammed H, Tasiakou, Niki, Diamantakos, Panagiotis, Reed, Miranda N, Panizzi, Peter, Boersma, Melissa D, Melliou, Eleni, El Sayed, Khalid A, Magiatis, Prokopios, Kaddoumi, Amal

“…Since the first discovery of its ibuprofen-like anti-inflammatory activity in 2005, the olive phenolic (−)-oleocanthal gained great scientific interest and…”
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In vitro evaluation of metabolism- and transporter-based drug interactions with sunscreen active ingredients by Volpe, Donna, Qusa, Mohammed

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Evaluation of In Vitro Metabolism- and Transporter-Based Drug Interactions with Sunscreen Active Ingredients by Qusa, Mohammed, Qosa, Hisham, Volpe, Donna A.

“…Purpose The aim of this study was to examine the ability of sunscreen active ingredients to inhibit in vitro drug metabolism via cytochrome P450 (CYP) enzymes…”
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Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer by Elkhalifa, Dana, Siddique, Abu Bakar, Qusa, Mohammed, Cyprian, Farhan S., El Sayed, Khalid, Alali, Feras, Al Moustafa, Ala-Eddin, Khalil, Ashraf

“…Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases…”
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IS/I--Oleocanthal Ex Vivo Modulatory Effects on Gut Microbiota by Qusa, Mohammed H, Abdelwahed, Khaldoun S, Hill, Ronald A, El Sayed, Khalid A

“…Compelling evidence points to the critical role of bioactive extra-virgin olive oil (EVOO) phenolics and gut microbiota (GM) interplay, but reliable models for…”
Get full text

Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on by Siddique, Abu Bakar, Ebrahim, Hassan, Mohyeldin, Mohamed, Qusa, Mohammed, Batarseh, Yazan, Fayyad, Ahmed, Tajmim, Afsana, Nazzal, Sami, Kaddoumi, Amal, El Sayed, Khalid

“…Epidemiological and clinical studies compellingly documented the ability of Mediterranean diet rich in extra-virgin olive oil (EVOO) to reduce breast and colon…”
Get full text

Therapeutic and Translational Applications of Extra-Virgin Olive Oil Phenolics by Qusa, Mohammed H

“…Natural products are chemically diverse structures with documented biological activity. The diverse and renewable nature of the primary and secondary natural…”
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