Search Results - "Quraishi, Imran"
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Is MORE better? Accumulating Evidence for ANT DBS in Epilepsy
Published in Epilepsy currents (01-12-2023)“…Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry Peltola J, Colon AJ,…”
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Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials
Published in Proceedings of the National Academy of Sciences - PNAS (10-01-2023)“…Vestibular hair cells transmit information about head position and motion across synapses to primary afferent neurons. At some of these synapses, the afferent…”
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Early detection rate changes from a brain‐responsive neurostimulation system predict efficacy of newly added antiseizure drugs
Published in Epilepsia (Copenhagen) (01-01-2020)“…Objective Brain‐responsive neurostimulation (RNS System, NeuroPace) is used to treat medically refractory focal epilepsy and also provides long‐term ambulatory…”
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Patient‐detectable responsive neurostimulation as a seizure warning system
Published in Epilepsia (Copenhagen) (01-07-2021)“…Many people with epilepsy are not aware of their seizures or do not have reliable auras. The responsive neurostimulation system (RNS) delivers stimulation…”
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5
Nonquantal transmission at the vestibular hair cell-calyx synapse: K LV currents modulate fast electrical and slow K + potentials
Published in Proceedings of the National Academy of Sciences - PNAS (10-01-2023)“…Vestibular hair cells transmit information about head position and motion across synapses to primary afferent neurons. At some of these synapses, the afferent…”
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An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents
Published in The Journal of neuroscience (11-09-2019)“…Mutations in the KCNT1 (Slack, KNa1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has…”
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Human slack potassium channel mutations increase positive cooperativity between individual channels
Published in Cell reports (Cambridge) (11-12-2014)“…Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined…”
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Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
Published in Cell reports (Cambridge) (26-03-2024)“…The KCNT1 gene encodes the sodium-activated potassium channel Slack (KCNT1, KNa1.1), a regulator of neuronal excitability. Gain-of-function mutations in humans…”
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An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack K Na Currents
Published in The Journal of neuroscience (11-09-2019)“…Mutations in the KCNT1 (Slack, K 1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has…”
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Combined neuromodulation and resection for functional cortex epilepsy: a case series
Published in Journal of neurosurgery (07-06-2024)“…Medically refractory epilepsy (MRE) often requires resection of the seizure onset zone (SOZ) for effective treatment. However, when the SOZ is in functional…”
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Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex
Published in The Journal of neuroscience (30-11-2022)“…The function of long-term memory is not just to reminisce about the past, but also to make predictions that help us behave appropriately and efficiently in the…”
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Intracranial Entrainment Reveals Statistical Learning across Levels of Abstraction
Published in Journal of cognitive neuroscience (01-08-2023)“…We encounter the same people, places, and objects in predictable sequences and configurations. Humans efficiently learn these regularities via statistical…”
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Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ channels
Published in Scientific reports (21-02-2020)“…Gain-of-function mutations in KCNT1 , the gene encoding Slack (K Na 1.1) channels, result in epilepsy of infancy with migrating focal seizures (EIMFS) and…”
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Remembering the pattern: A longitudinal case study on statistical learning in spatial navigation and memory consolidation
Published in Neuropsychologia (09-09-2022)“…Distinct brain systems are thought to support statistical learning over different timescales. Regularities encountered during online perceptual experience can…”
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Electronic seizure diaries for clinical care and research
Published in Epileptic disorders (01-10-2022)“…Objective. People with epilepsy often record their seizures in diaries. While seizure diaries can be kept using paper and digital notes or calendars,…”
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Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing
Published in Epilepsy & behavior (01-09-2022)“…•The RNS System allows recording hippocampal intracranial EEG during Wada testing.•Intracarotid methohexital induces marked ipsilateral hippocampal…”
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Gerstmann Syndrome Deconstructed by Cortical Stimulation
Published in Neurology (31-08-2021)Get full text
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Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice
Published in The FASEB journal (01-12-2021)“…Mutations in KCNC3, the gene that encodes the Kv3.3 voltage dependent potassium channel, cause Spinocerebellar Ataxia type 13 (SCA13), a disease associated…”
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Subacute combined degeneration of the spinal cord in a patient with nitrous oxide use and autoimmune atrophic gastritis
Published in BMJ case reports (30-11-2023)“…Nitrous oxide is among the most common drugs used by adolescents and young adults, and its neuropsychiatric sequelae are severe but reversible with timely…”
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A multicenter retrospective study of patients treated in the thalamus with responsive neurostimulation
Published in Frontiers in neurology (08-09-2023)“…For drug resistant epilepsy patients who are either not candidates for resective surgery or have already failed resective surgery, neuromodulation is a…”
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