Search Results - "Quitterer, Ursula"

Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers by Quitterer, Ursula, Fu, Xuebin, Pohl, Armin, Bayoumy, Karam M., Langer, Andreas, AbdAlla, Said

“…Preeclampsia is the most frequent pregnancy-related complication worldwide with no cure. While a number of molecular features have emerged, the underlying…”
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ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease by AbdAlla, Said, Langer, Andreas, Fu, Xuebin, Quitterer, Ursula

“…Increased generation of reactive oxygen species (ROS) is a significant pathological feature in the brains of patients with Alzheimer's disease (AD)…”
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Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation by Abd Alla, Joshua, Jamous, Yahya F., Quitterer, Ursula

“…Heart failure is a major cause of death worldwide with insufficient treatment options. In the search for pathomechanisms, we found up-regulation of an enzyme,…”
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Pathological AT1R-B2R Protein Aggregation and Preeclampsia by Quitterer, Ursula, AbdAlla, Said

“…Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include…”
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Discovery of Pathologic GPCR Aggregation by Quitterer, Ursula, AbdAlla, Said

“…The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore…”
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Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness by AbdAlla, Said, Lother, Heinz, el Massiery, Adel, Quitterer, Ursula

“…Several examples of functional G-protein-coupled receptor heterodimers have been identified. However, it is not known whether receptor heterodimerization is…”
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The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart by Abd Alla, Joshua, Quitterer, Ursula

“…The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the…”
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Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 by Quitterer, Ursula, Lorenz, Kristina, Lohse, Martin J

“…Feedback inhibition is a fundamental principle in signal transduction allowing rapid adaptation to different stimuli. In mammalian cells, the major feedback…”
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AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration by ABDALLA, S, LOTHER, H, QUITTERER, U

“…The vasopressor angiotensin II regulates vascular contractility and blood pressure through binding to type 1 angiotensin II receptors (AT1; refs 1, 2)…”
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Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis by AbdAlla, Said, Lother, Heinz, Langer, Andreas, el Faramawy, Yasser, Quitterer, Ursula

“…Many G protein-coupled receptors form dimers in cells. However, underlying mechanisms are barely understood. We report here that intracellular factor XIIIA…”
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Inhibition of ACE Retards Tau Hyperphosphorylation and Signs of Neuronal Degeneration in Aged Rats Subjected to Chronic Mild Stress by Elfaramawy, Yasser, Abdelbaset, Ahmed, el Hakim, Ahmed, AbdAlla, Said, Quitterer, Ursula

“…With increasing life expectancy, Alzheimer’s disease (AD) and other types of age-associated dementia are on the rise worldwide. Treatment approaches for…”
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Angiotensin II AT2 Receptor Oligomers Mediate G-protein Dysfunction in an Animal Model of Alzheimer Disease by AbdAlla, Said, Lother, Heinz, el Missiry, Ahmed, Langer, Andreas, Sergeev, Pavel, el Faramawy, Yasser, Quitterer, Ursula

“…Progressive neurodegeneration and decline of cognitive functions are major hallmarks of Alzheimer disease (AD). Neurodegeneration in AD correlates with…”
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Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure by Wolf, Stefan, Abd Alla, Joshua, Quitterer, Ursula

“…Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms…”
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Angiotensin-converting Enzyme Inhibition Down-regulates the Pro-atherogenic Chemokine Receptor 9 (CCR9)-Chemokine Ligand 25 (CCL25) Axis by Abd Alla, Joshua, Langer, Andreas, Elzahwy, Sherif S., Arman-Kalcek, Gökhan, Streichert, Thomas, Quitterer, Ursula

“…Many experimental and clinical studies suggest a relationship between enhanced angiotensin II release by the angiotensin-converting enzyme (ACE) and the…”
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Dominant Negative AT2 Receptor Oligomers Induce G-protein Arrest and Symptoms of Neurodegeneration by AbdAlla, Said, Lother, Heinz, el Missiry, Ahmed, Sergeev, Pavel, Langer, Andreas, el Faramawy, Yasser, Quitterer, Ursula

“…Neurodegeneration in Alzheimer’s disease (AD) correlates with dysfunction of signaling mediated by Gαq/11. Nondissociable angiotensin II AT2 receptor oligomers…”
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Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor by Perhal, Alexander, Wolf, Stefan, Jamous, Yahya F, Langer, Andreas, Abd Alla, Joshua, Quitterer, Ursula

“…Atherosclerosis and ensuing cardiovascular disease are major causes of death with insufficient treatment options. In search for pathomechanisms of…”
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Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system by Quitterer, Ursula, AbdAlla, Said

“…[Display omitted] With ageing of the global society, the frequency of ageing-related neurodegenerative diseases such as Alzheimer`s disease (AD) is on the rise…”
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SUMO-1 Controls the Protein Stability and the Biological Function of Phosducin by Klenk, Christoph, Humrich, Jan, Quitterer, Ursula, Lohse, Martin J.

“…Phosducin regulates Gβγ-stimulated signaling by binding to Gβγ subunits of heterotrimeric G-proteins. Control of phosducin activity by phosphorylation is well…”
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Crosstalk between Gαi- and Gαq-coupled receptors is mediated by Gβγ exchange by Quitterer, Ursula, Lohse, Martin J.

“…Activation of Gα i -coupled receptors often causes enhancement of the inositol phosphate signal triggered by Gα q -coupled receptors. To investigate the…”
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Involvement of the Amino Terminus of the B2 Receptor in Agonist-induced Receptor Dimerization by AbdAlla, Said, Zaki, Essam, Lother, Heinz, Quitterer, Ursula

“…The mechanisms and the functional importance of G-protein-coupled receptor dimerization are poorly understood. We therefore analyzed dimerization of the…”
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