Interaction of maternal separation on the UCh rat Cerebellum

Interaction of maternal separation on the UCh rat Cerebellum

ABSTRACT Maternal care is the main source of signals and stimuli for proper development, growth, and production of adjustment responses to stressful factors. Adverse experiences in childhood are associated with a vulnerability to developing abusive ethanol ingestion via alterations of the response o...

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Published in:Microscopy research and technique Vol. 77; no. 1; pp. 44 - 51
Main Authors: Oliveira, S.A., Fontanelli, B. A. F., Stefanini, M.A., Chuffa, L.G.A., Teixeira, G.R., Lizarte, F.S.N., Tirapelli, L.F., Quitete, V.H.A., Matheus, S.M.M., Padovani, C.R., Martinez, M., Martinez, F.E.
Format: Journal Article
Language:English
Published: United States Blackwell Publishing Ltd 01-01-2014
Wiley Subscription Services, Inc
Subjects:
Age
Alcoholism - genetics
Alcoholism - metabolism
Alcoholism - psychology
Animals
Cellular
Cerebellum
Cerebellum - growth & development
Cerebellum - metabolism
Disease Models, Animal
Eating
Ethanol
Ethanol - adverse effects
Ethanol - metabolism
Ethyl alcohol
Female
Humans
Male
Males
Maternal Deprivation
maternal separation
Organ Size
Rats
Receptor, IGF Type 1 - genetics
Receptor, IGF Type 1 - metabolism
Separation
UCh rat
maternal separation
cerebellum
UCh rat
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Summary:ABSTRACT Maternal care is the main source of signals and stimuli for proper development, growth, and production of adjustment responses to stressful factors. Adverse experiences in childhood are associated with a vulnerability to developing abusive ethanol ingestion via alterations of the response of the hypothalamic–pituitary–adrenal axis. Alcoholism causes global brain abnormalities, with the cerebellum being one of the most susceptible areas. We evaluated the effect of maternal separation on the cerebellum structure of male UCh rats. Adult male UChA (low 10% ethanol consumption) and UChB (high 10% ethanol consumption) rats were divided in to four experimental groups: (1) UChA, (2) UChA maternal separation (MS), (3) UChB, and (4) UChB MS. The MS occurred between the 4th and 14th days of age, for 240 min day−1. Euthanasia was performed at 120 days of age. An image analysis system was used to measure cerebellar cortical height and Purkinje cellular area and height in five rats from each group. The cerebellar sections were stained with antibodies against IGFR‐I. MS did not alter the ethanol consumption of UChA and UChB rats. Corticosterone level was significantly higher in UChA MS and UChB MS rats than in UChA and UChB rats. The Purkinje cellular area and height were higher in UChA MS rats. IGFR‐I expression was observed in the cortical glomerular area of UChA MS and UChB MS rats. MS altered the Purkinje cells in the cerebella of male UCh rats. Microsc. Res. Tech. 77:44–51, 2014. © 2013 Wiley Periodicals, Inc.
Bibliography:ark:/67375/WNG-Q8NHR6FZ-V
istex:C0FFADC67E6573C70C8E90BA334ABD8A5FFF8EFB
ArticleID:JEMT22311
REVIEW EDITOR: Prof. George Perry
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.22311