Search Results - "Quistad, Gary B"

Organophosphate Toxicology:  Safety Aspects of Nonacetylcholinesterase Secondary Targets by Casida, John E, Quistad, Gary B

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Golden Age of Insecticide Research: Past, Present, or Future? by Casida, John E, Quistad, Gary B

“…Insecticide research led to the first "complete" victories in combatting pests almost 50 years ago with the chlorinated hydrocarbons followed quickly by the…”
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Evidence That Mouse Brain Neuropathy Target Esterase Is a Lysophospholipase by Quistad, Gary B., Barlow, Carrolee, Winrow, Christopher J., Sparks, Susan E., Casida, John E.

“…Neuropathy target esterase (NTE) is inhibited by several organophosphorus (OP) pesticides, chemical warfare agents, lubricants, and plasticizers, leading to…”
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Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity by Barlow, Carrolee, Winrow, Christopher J, Hemming, Matthew L, Allen, Duane M, Quistad, Gary B, Casida, John E

“…Neuropathy target esterase (NTE) is involved in neural development and is the target for neurodegeneration induced by selected organophosphorus pesticides and…”
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Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice by Quistad, Gary B., Klintenberg, Rebecka, Caboni, Pierluigi, Liang, Shannon N., Casida, John E.

“…Three components of the cannabinoid system are sensitive to selected organophosphorus (OP) compounds: monoacylglycerol (MAG) lipase that hydrolyzes the major…”
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Blood Acylpeptide Hydrolase Activity Is a Sensitive Marker for Exposure to Some Organophosphate Toxicants by Quistad, Gary B., Klintenberg, Rebecka, Casida, John E.

“…Acylpeptide hydrolase (APH) unblocks N-acetyl peptides. It is a major serine hydrolase in rat blood, brain, and liver detected by derivatization with…”
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A Brain Detoxifying Enzyme for Organophosphorus Nerve Poisons by Nomura, Daniel K., Leung, Donmienne, Chiang, Kyle P., Quistad, Gary B., Cravatt, Benjamin F., Casida, John E.

“…Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP…”
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Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides by Quistad, Gary B., Nomura, Daniel K., Sparks, Susan E., Segall, Yoffi, Casida, John E.

“…Binding of the endocannabinoid anandamide or of Δ 9-tetrahydrocannabinol to the agonist site of the cannabinoid receptor (CB1) is commonly assayed with [ 3H]CP…”
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Selective Inhibitors of Fatty Acid Amide Hydrolase Relative to Neuropathy Target Esterase and Acetylcholinesterase: Toxicological Implications by Quistad, Gary B., Sparks, Susan E., Segall, Yoffi, Nomura, Daniel K., Casida, John E.

“…Fatty acid amide hydrolase (FAAH) plays an important role in nerve function by regulating the action of endocannabinoids (e.g., anandamide) and hydrolyzing a…”
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Serine hydrolase targets of organophosphorus toxicants by Casida, John E., Quistad, Gary B.

“…Acetylcholinesterase (AChE) is one of several hundred serine hydrolases in people potentially exposed to about 80 organophosphorus (OP) compounds important as…”
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Acephate Insecticide Toxicity:  Safety Conferred by Inhibition of the Bioactivating Carboxyamidase by the Metabolite Methamidophos by Mahajna, Mahmoud, Quistad, Gary B, Casida, John E

“…Acephate is an important systemic organophosphorus insecticide with toxicity attributed to bioactivation on metabolic conversion to methamidophos (or an…”
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Dialkylquinoneimine metabolites of chloroacetanilide herbicides induce sister chromatid exchanges in cultured human lymphocytes by Hill, Anna B, Jefferies, Phillip R, Quistad, Gary B, Casida, John E

“…Some of the most widely-used herbicides are the chloroacetanilides exemplified by alachlor and butachlor (derived from 2,6-diethylaniline) and metolachlor and…”
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Glutathione activation of chloropicrin in the Salmonella mutagenicity test by Schneider, Manfred, Quistad, Gary B, Casida, John E

“…Chloropicrin (CCl3NO2) is a major soil fumigant for control of fungi, insects and nematodes and may by formed by chlorination of drinking water. It is also a…”
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Each Lipase Has a Unique Sensitivity Profile for Organophosphorus Inhibitors by Quistad, Gary B., Liang, Shannon N., Fisher, Karl J., Nomura, Daniel K., Casida, John E.

“…Lipases sensitive to organophosphorus (OP) inhibitors play critical roles in cell regulation, nutrition, and disease, but little is known on the toxicological…”
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Fatty Acid Amide Hydrolase Inhibition by Neurotoxic Organophosphorus Pesticides by Quistad, Gary B., Sparks, Susan E., Casida, John E.

“…Organophosphorus (OP) compound-induced inhibition of acetylcholinesterase (AChE) and neuropathy target esterase explains the rapid onset and delayed neurotoxic…”
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Serine Hydrolase KIAA1363:  Toxicological and Structural Features with Emphasis on Organophosphate Interactions by Nomura, Daniel K, Durkin, Kathleen A, Chiang, Kyle P, Quistad, Gary B, Cravatt, Benjamin F, Casida, John E

“…Serine hydrolase KIAA1363 is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated by and hydrolyzing low…”
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Lysophospholipase inhibition by organophosphorus toxicants by Quistad, Gary B., Casida, John E.

“…Lysophospholipases (LysoPLAs) are a large family of enzymes for removing lysophospholipids from cell membranes. Potent inhibitors are needed to define the…”
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Chlorpyrifos Oxon Potentiates Diacylglycerol-Induced Extracellular Signal-Regulated Kinase (ERK 44/42) Activation, Possibly by Diacylglycerol Lipase Inhibition by Bomser, Joshua A., Quistad, Gary B., Casida, John E.

“…Chlorpyrifos oxon (CPO) activates extracellular signal-regulated kinase (ERK 44/42) in Chinese hamster ovary (CHOK1) cells but the mechanism is not defined…”
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Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates by Quistad, Gary B., Fisher, Karl J., Owen, Sarah C., Klintenberg, Rebecka, Casida, John E.

“…Platelet-activating factor (PAF) is a potent endogenous phospholipid modulator of diverse biological activities, including inflammation and shock. PAF levels…”
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Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors by Segall, Yoffi, Quistad, Gary B., Nomura, Daniel K., Casida, John E.

“…Arachidonylsulfonyl fluoride ( 3), reported here for the first time, is similar in potency to its known methyl arachidonylfluorophosphonate ( 2) analogue as an…”
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