Transcutaneous Parasacral Electrical Stimulation vs Oxybutynin for the Treatment of Overactive Bladder in Children: A Randomized Clinical Trial

Purpose We determined the effectiveness of 2 methods to treat overactive bladder in children using intragroup and intergroup comparisons in a randomized clinical trial. Materials and Methods Nine boys and 19 girls with a mean ± SD age of 6.4 ± 2.18 years were randomly divided into group 1—parasacral...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of urology Vol. 193; no. 5; pp. 1749 - 1753
Main Authors:	Quintiliano, Fábio, Veiga, Maria Luiza, Moraes, Marília, Cunha, Carolina, de Oliveira, Liliana Fajardo, Lordelo, Patrícia, Bastos Netto, José Murillo, Barroso Júnior, Ubirajara
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-05-2015
Subjects:	adverse effects Child Comorbidity constipation Constipation - epidemiology Constipation - therapy Female Humans Male Mandelic Acids - therapeutic use Muscarinic Antagonists - therapeutic use overactive oxybutynin Transcutaneous Electric Nerve Stimulation Treatment Outcome urinary bladder Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - epidemiology Urinary Bladder, Overactive - therapy Urology constipation VV transcutaneous electric nerve stimulation urinary bladder PTENS VAS UTI visual analog scale parasacral transcutaneous electrical stimulation voiding frequency dysfunctional voiding score system VF OAB DVSS VUR oxybutynin overactive vesicoureteral reflux voided volume adverse effects overactive bladder urinary tract infection
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Purpose We determined the effectiveness of 2 methods to treat overactive bladder in children using intragroup and intergroup comparisons in a randomized clinical trial. Materials and Methods Nine boys and 19 girls with a mean ± SD age of 6.4 ± 2.18 years were randomly divided into group 1—parasacral transcutaneous electrical stimulation with placebo drug and group 2—oxybutynin with sham scapular electrical therapy. Success was assessed by 1) the rate of complete symptom resolution, 2) a visual analog scale of 0 to 10, 3) the dysfunctional voiding score system, 4) voiding diary records, 5) Rome III criteria and 6) side effect frequency in each group. Results A total of 13 and 15 patients were randomized to groups 1 and 2, respectively. Symptoms completely resolved in 6 patients in group 1 (46%) and 3 in group 2 (20%) (p = 0.204). A statistically significant improvement was found in the 2 groups in the dysfunctional voiding score system and voiding diary records. However, no statistically significant difference was found between the groups in the visual analog scale score, voiding frequency, and maximum and mean voided volume (p = 0.295, 0.098, 0.538 and 0.650, respectively). Constipation improved in 100% of group 1 patients but in only 55% in group 2 (p = 0.031 vs 0.073). Group 1 showed no side effects while dry mouth, hyperthermia and hyperemia developed in 58%, 25% and 50% of group 2 patients (p = 0.002, 0.096 and 0.005, respectively). Treatment was discontinued by 13.3% of patients in group 2. Conclusions Parasacral transcutaneous electrical stimulation was as effective as oxybutynin to treat overactive bladder in children. However, transcutaneous parasacral electrical stimulation was more effective against constipation and showed no detectable side effects. Oxybutynin was more effective for decreasing voiding frequency.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0022-5347 1527-3792
DOI:	10.1016/j.juro.2014.12.001