Search Results - "Quintero, Marisol"

Ki67 Changes Identify Worse Outcomes in Residual Breast Cancer Tumors After Neoadjuvant Chemotherapy by Cabrera‐Galeana, Paula, Muñoz‐Montaño, Wendy, Lara‐Medina, Fernando, Alvarado‐Miranda, Alberto, Pérez‐Sánchez, Victor, Villarreal‐Garza, Cynthia, Quintero, R. Marisol, Porras‐Reyes, Fany, Bargallo‐Rocha, Enrique, Del Carmen, Ignacio, Mohar, Alejandro, Arrieta, Oscar

“…Background Several breast cancer (BC) trials have adopted pathological complete response (pCR) as a surrogate marker of long‐term treatment efficacy. In…”
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Mitochondria as Signaling Organelles in the Vascular Endothelium by Quintero, Marisol, Colombo, Sergio L., Godfrey, Andrew, Moncada, Salvador

“…Vascular endothelial cells are highly glycolytic and consume relatively low amounts of oxygen (O₂) compared with other cells. We have confirmed that oxidative…”
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Immunotherapeutic effects of intratumoral nanoplexed poly I:C by Aznar, M Angela, Planelles, Lourdes, Perez-Olivares, Mercedes, Molina, Carmen, Garasa, Saray, Etxeberría, Iñaki, Perez, Guiomar, Rodriguez, Inmaculada, Bolaños, Elixabet, Lopez-Casas, Pedro, Rodriguez-Ruiz, Maria E, Perez-Gracia, Jose L, Marquez-Rodas, Ivan, Teijeira, Alvaro, Quintero, Marisol, Melero, Ignacio

“…Poly I:C is a powerful immune adjuvant as a result of its agonist activities on TLR-3, MDA5 and RIG-I. BO-112 is a nanoplexed formulation of Poly I:C complexed…”
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Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production by Funes, Juan M, Quintero, Marisol, Henderson, Stephen, Martinez, Dolores, Qureshi, Uzma, Westwood, Claire, Clements, Mark O, Bourboulia, Dimitra, Pedley, R. Barbara, Moncada, Salvador, Boshoff, Chris

“…An increased dependency on glycolysis for ATP production is considered to be a hallmark of tumor cells. Whether this increase in glycolytic activity is due…”
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Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic by Alvarez, Maite, Molina, Carmen, Garasa, Saray, Ochoa, Maria C, Rodriguez-Ruiz, Maria E, Gomis, Gabriel, Cirella, Assunta, Olivera, Irene, Glez-Vaz, Javier, Gonzalez-Gomariz, Jose, Luri-Rey, Carlos, Azpilikueta, Arantza, Bolaños, Elixabet, Teijeira, Alvaro, Berraondo, Pedro, Quintero, Marisol, Melero, Ignacio

“…BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice…”
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Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy by Alvarez, Maite, Molina, Carmen, De Andrea, Carlos E, Fernandez-Sendin, Myriam, Villalba, Maria, Gonzalez-Gomariz, Jose, Ochoa, Maria Carmen, Teijeira, Alvaro, Glez-Vaz, Javier, Aranda, Fernando, Sanmamed, Miguel F, Rodriguez-Ruiz, Maria E, Fan, Xinyi, Shen, Wen H, Berraondo, Pedro, Quintero, Marisol, Melero, Ignacio

“…BackgroundBO-112 is a nanoplexed form of polyinosinic:polycytidylic acid that acting on toll-like receptor 3 (TLR3), melanoma differentiation-associated…”
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Efficacy of LCMV-based cancer immunotherapies is unleashed by intratumoral injections of polyI:C by Gomar, Celia, Di Trani, Claudia Augusta, Bella, Angela, Arrizabalaga, Leire, Gonzalez-Gomariz, Jose, Fernandez-Sendin, Myriam, Alvarez, Maite, Russo-Cabrera, Joan Salvador, Ardaiz, Nuria, Aranda, Fernando, Schippers, Timo, Quintero, Marisol, Melero, Ignacio, Orlinger, Klaus K, Lauterbach, Henning, Berraondo, Pedro

“…BackgroundLymphocytic choriomeningitis virus (LCMV) belongs to the Arenavirus family known for inducing strong cytotoxic T-cell responses in both mice and…”
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Endogenous NO Regulates Superoxide Production at Low Oxygen Concentrations by Modifying the Redox State of Cytochrome c Oxidase by Palacios-Callender, Miriam, Quintero, Marisol, Hollis, Veronica S., Springett, Roger J., Moncada, Salvador

“…We have investigated in whole cells whether, at low oxygen concentrations ([ O2]), endogenous nitric oxide (NO) modulates the redox state of the mitochondrial…”
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Inhibition of Mitochondrial Respiration by Endogenous Nitric Oxide: A Critical Step in Fas Signaling by Beltrán, Belén, Quintero, Marisol, García-Zaragozá, Eugenia, O'Connor, Enrique, Esplugues, Juan V., Moncada, Salvador

“…We have found that activation of human adult T cell leukemia (Jurkat) cells with anti-Fas Ab leads, in a concentration-dependent manner, to an early burst of…”
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Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol by Hagen, Thilo, D’Amico, Gabriela, Quintero, Marisol, Palacios-Callender, Miriam, Hollis, Veronica, Lam, Francis, Moncada, Salvador

“…2-Methoxyestradiol (2ME2), a naturally occurring metabolite of estradiol, is known to have antiproliferative, antiangiogenic, and proapoptotic activity…”
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Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma by Kalbasi, Anusha, Tariveranmoshabad, Mito, Hakimi, Kevin, Kremer, Sarah, Campbell, Katie M, Funes, Juan M, Vega-Crespo, Agustin, Parisi, Giulia, Champekar, Ameya, Nguyen, Christine, Torrejon, Davis, Shin, Daniel, Zaretsky, Jesse M, Damoiseaux, Robert D, Speiser, Daniel E, Lopez-Casas, Pedro P, Quintero, Marisol, Ribas, Antoni

“…Defects in tumor-intrinsic interferon (IFN) signaling result in failure of immune checkpoint blockade (ICB) against cancer, but these tumors may still maintain…”
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Abstract 1790: BO-112 as a modifier of the tumor microenvironment for liver metastases by Quintero, Marisol, Pons, Vanesa, Maciá, Sonia, Rojas, María, López, Javier Sánchez, Kanters, Desiree, Escuin-Ordinas, Helena, Branum, Mark, Funes, Juan M., Pozuelo, Mercedes, Doherty, Mike

“…Abstract Introduction: BO-112 is an analogue of double-stranded viral RNA which is an agonist of TLR3, RIG-1 and MDA5. It is currently in phase II clinical…”
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Abstract CT221: A phase I study of intratumoral BO-112 and nivolumab for resectable soft tissue sarcoma by Kalbasi, Anusha, Eilber, Fritz C., Singh, Arun, Chmielowski, Bartosz, Bernthal, Nicholas, Crawford, Brooke, Crompton, Joseph G., Ghazikhanian, Varand, Seeger, Leanne, Motamedi, Kambiz, Douek, Michael L., Felix, Carol, Basehart, Vincent, Escuin-Ordinas, Helena, Quintero, Marisol, Macia, Sonia

“…Abstract Background: BO-112 is a double stranded synthetic RNA formulated with polyethyleneimine. By mimicking a viral infection, it mobilizes the immune…”
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Abstract CT192: Phase IIa open-label clinical study of intratumoural administration of BO-112 in combination with pembrolizumab in subjects with liver metastasis from colorectal cancer or gastric/gastro-oesophageal junction cancer by Ponz-Sarvisé, Mariano, Élez, Elena, Muñoz, Andrés, Van den Eynde, Marc, Rampoldi, Antonio Gaetano, Hendlisz, Alain, Prenen, Hans, Rodríguez, Mercedes, Cano, María Teresa, Chaney, Marya, Escuin, Helena, Pons, Vanesa, Quintero, Marisol, Cervantes, Andrés

“…Abstract Protocol tittle: Study of BO-112 with pembrolizumab for colorectal or gastric/GEJ cancer with liver metastasis.Background: Gastric (GC),…”
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Abstract CT233: Phase 2 clinical study to evaluate the efficacy and safety of intratumoral BO-112 in combination with pembrolizumab in patients with advanced melanoma that have progressive disease on anti-PD-1-based therapy by Márquez-Rodas, Iván, Fernández de Sanmamed Gutiérrez, Miguel, Cao, María González, Arance, Ana M., Berrocal, Alfonso, Castañon, Eduardo, España, Sofía, Cerezuela-Fuentes, Pablo, Rodríguez-Moreno, Juan F., Criado, Pilar López, Oramas, Juana, de la Cruz Merino, Luis, Dalle, Stéphane, Dutriaux, Caroline, Charles, Julie, Robert, Caroline, Dréno, Brigitte, Montaudié, Henri, Saiag, Philippe, Sánchez-López, Javier, Rojas, María, Escuin-Ordinas, Helena, Sanz, Vanesa Pons, Maciá, Sonia, Quintero, Marisol

“…Abstract Background: BO-112 is a double stranded synthetic RNA formulated with polyethyleneimine (PEI), that acts as an agonist to toll-like receptor 3 and…”
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Combination of radiomic and biomarker signatures as exploratory objective in a phase II trial with intratumoral BO-112 plus pembrolizumab for advanced melanoma by Marquez-Rodas, Ivan, Dalle, Stéphane, Castanon, Eduardo, Sanmamed, Miguel F., Arance, Ana Maria, Cerezuela-Fuentes, Pablo, Martin Huertas, Roberto, Rodríguez-Moreno, Juan Francisco, Gonzalez-Cao, Maria, Muñoz-Couselo, Eva, Martin-Liberal, Juan, Rodriguez-Abreu, Delvys, Alberich-Bayarri, Ángel, Mayorga-Ruiz, Irene, Molina Vila, Miguel Angel, Román, Ruth, Chaney, Marya F., Sánchez López, Javier, Maciá, Sonia, Quintero, Marisol

“…Abstract only TPS9586 Background: Intratumoral immunotherapies are gaining interest in oncology, particularly in melanoma. These therapies, however, have faced…”
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Abstract 3446: Radiation and intratumoral activation of double-stranded RNA sensors redirects myeloid cells and primes adaptive immunity by Deng, Jie, Chin, Scott C., Tariveranmoshabad, Mito, Graham, Danielle S., Lee, Hailey R., Quintero, Marisol, Schaue, Dorthe, Kalbasi, Anusha

“…Abstract Background: Undifferentiated pleomorphic sarcoma (UPS) is a common aggressive sarcoma subtype for which existing therapies are ineffective. Immune…”
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Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control by Rodriguez-Ruiz, Maria E, Serrano-Mendioroz, Irantzu, Garate-Soraluze, Eneko, Sánchez-Mateos, Paloma, Barrio-Alonso, Celia, Rodríguez López, Inmaculada, Diaz Pascual, Victor, Arbea Moreno, Leire, Alvarez, Maite, Sanmamed, Miguel F, Perez-Gracia, Jose Luis, Escuin-Ordinas, Helena, Quintero, Marisol, Melero, Ignacio

“…Radioimmunotherapy combines irradiation of tumor lesions with immunotherapy to achieve local and abscopal control of cancer. Most immunotherapy agents are…”
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Abstract 6216: Intratumoral B0112 in combination with radiotherapy synergizes to achieve CD8 T cell mediated local tumor control by Rodriguez-Ruiz, Maria.E., serrano, Irantzu, Garate, Eneko, Rodriguez, Inmaculada, alvarez, maite, Molina, Carmen, de Sanmamed, Miguel Fernandez, Arbea, Leire, Moreno, Marta, Quintero, Marisol, Melero, Ignacio

“…Abstract Background: Radioimmunotherapy combines irradiation of tumor lesions with immunotherapy to achieve local and abscopal control of cancer. Most…”
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Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1α in cancer : Role of free radical formation by QUINTERO, Marisol, BRENNAN, Peter A, THOMAS, Gareth J, MONCADA, Salvador

“…Abstract Widespread expression of the α-subunit of hypoxia-inducible factor (HIF-1α) was observed in samples of human oral squamous cell carcinoma. In all the…”
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