Activity of hepatic enzymes from week sixteen of pregnancy

Activity of hepatic enzymes from week sixteen of pregnancy

This study was undertaken to determine the prevalence, epidemiology, and mother-child repercussions of increased alanine-aminotransferase levels from week 16 of pregnancy. A longitudinal observational study of 381 pregnant women. The cause of increased alanine-aminotransferase levels during pregnanc...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology Vol. 193; no. 6; pp. 2010 - 2016
Main Authors: Ruiz-Extremera, Angeles, López-Garrido, María A., Barranco, Enriqueta, Quintero, María D., Ocete-Hita, Esther, Muñoz de Rueda, Paloma, Gila, Ana, Salmerón, Javier
Format: Journal Article
Language:English
Published: Philadelphia, PA Mosby, Inc 01-12-2005
Elsevier
Subjects:
Adolescent
Adult
Alanine Transaminase - blood
Alanine-aminotransferase
Biological and medical sciences
Female
gamma-Glutamyltransferase - blood
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
L-Lactate Dehydrogenase - blood
Liver - enzymology
Liver enzymes
Medical sciences
Pregnancy
Pregnancy - blood
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Socioeconomic Factors
Pregnancy
Liver enzymes
Alanine-aminotransferase
Digestive system
Enzyme
Transaminases
Transferases
Liver
Gynecology
Pregnancy Liver enzymes Alanine-aminotransferase
Alanine transaminase
Female
Obstetrics
Biological activity
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Description
Summary:This study was undertaken to determine the prevalence, epidemiology, and mother-child repercussions of increased alanine-aminotransferase levels from week 16 of pregnancy. A longitudinal observational study of 381 pregnant women. The cause of increased alanine-aminotransferase levels during pregnancy and repercussions on the neonate were studied in 283 cases. Statistical analysis was performed with Mann-Whitney test, χ 2 test, or the Fisher exact test. The mean age of the mothers was 29.9 ± 4.8 years. Twenty-five percent presented increased gamma-glutamyl-transpeptidase, alkaline phophatase, and dehydrogenase lactate from week 32. Increased alanine-aminotransferase was observed in 7.4% (95% CI, 5.00%-10.57%) of cases. Clinical disorders were light, transitory, and with no apparent cause, except for 1 hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, 3 preeclampsias, and 1 gravidic cholestasis. No statistically significant differences were observed in the group of mother-child with alanine-aminotransferase normal or increased. Most increases in alanine-aminotransferase from week 16 of pregnancy are transitory, non-specific, and have no repercussions on mother or child.
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ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2005.04.045