Search Results - "Quintero, L."

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity by Piedra-Quintero, Zayda L, Wilson, Zachary, Nava, Porfirio, Guerau-de-Arellano, Mireia

“…CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular signaling activity, or as a receptor with adhesive functions. CD38 can be…”
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Cross‐linking disulfide bonds govern solution structures of diabodies by Math, Barbara A., Waibl, Franz, Lamp, Leonida M., Fernández‐Quintero, Monica L., Liedl, Klaus R.

“…In the last years, antibodies have emerged as a promising new class of therapeutics, due to their combination of high specificity with long serum half‐life and…”
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A Plant Pathogen Type III Effector Protein Subverts Translational Regulation to Boost Host Polyamine Levels by Wu, Dousheng, von Roepenack-Lahaye, Edda, Buntru, Matthias, de Lange, Orlando, Schandry, Niklas, Pérez-Quintero, Alvaro L., Weinberg, Zasha, Lowe-Power, Tiffany M., Szurek, Boris, Michael, Anthony J., Allen, Caitilyn, Schillberg, Stefan, Lahaye, Thomas

“…Pathogenic bacteria inject effector proteins into host cells to manipulate cellular processes and facilitate the infection. Transcription-activator-like…”
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Akt isoforms in the immune system by Guerau-de-Arellano, Mireia, Piedra-Quintero, Zayda L, Tsichlis, Philip N

“…Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon…”
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MorTAL Kombat: the story of defense against TAL effectors through loss-of-susceptibility by Hutin, Mathilde, Pérez-Quintero, Alvaro L, Lopez, Camilo, Szurek, Boris

“…Many plant-pathogenic xanthomonads rely on Transcription Activator-Like (TAL) effectors to colonize their host. This particular family of type III effectors…”
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Phage display assisted discovery of a pH‐dependent anti‐α‐cobratoxin antibody from a natural variable domain library by Tulika, Tulika, Pedersen, Rasmus W., Rimbault, Charlotte, Ahmadi, Shirin, Rivera‐de‐Torre, Esperanza, Fernández‐Quintero, Monica L., Loeffler, Johannes R., Bohn, Markus‐Frederik, Ljungars, Anne, Ledsgaard, Line, Voldborg, Bjørn G., Ruso‐Julve, Fulgencio, Andersen, Jan Terje, Laustsen, Andreas H.

“…Recycling IgG antibodies bind to their target antigen at physiological pH in the blood stream and release them upon endocytosis when pH levels drop, allowing…”
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CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling by Pelizzari, Simone, Heiss, Martin C., Fernández-Quintero, Monica L., El Ghaleb, Yousra, Liedl, Klaus R., Tuluc, Petronel, Campiglio, Marta, Flucher, Bernhard E.

“…Skeletal muscle contractions are initiated by action potentials, which are sensed by the voltage-gated calcium channel (Ca V 1.1) and are conformationally…”
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Defining and Studying B Cell Receptor and TCR Interactions by Rappazzo, C Garrett, Fernández-Quintero, Monica L, Mayer, Andreas, Wu, Nicholas C, Greiff, Victor, Guthmiller, Jenna J

“…BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by which the adaptive immune system recognizes foreign and self-antigens, playing an…”
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Simulation-optimization methods for designing and assessing resilient supply chain networks under uncertainty scenarios: A review by Tordecilla, Rafael D., Juan, Angel A., Montoya-Torres, Jairo R., Quintero-Araujo, Carlos L., Panadero, Javier

“…The design of supply chain networks (SCNs) aims at determining the number, location, and capacity of production facilities, as well as the allocation of…”
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An improved method for TAL effectors DNA-binding sites prediction reveals functional convergence in TAL repertoires of Xanthomonas oryzae strains by Pérez-Quintero, Alvaro L, Rodriguez-R, Luis M, Dereeper, Alexis, López, Camilo, Koebnik, Ralf, Szurek, Boris, Cunnac, Sebastien

“…Transcription Activators-Like Effectors (TALEs) belong to a family of virulence proteins from the Xanthomonas genus of bacterial plant pathogens that are…”
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Functional analysis of African Xanthomonas oryzae pv. oryzae TALomes reveals a new susceptibility gene in bacterial leaf blight of rice by Tran, Tuan T, Pérez-Quintero, Alvaro L, Wonni, Issa, Carpenter, Sara C D, Yu, Yanhua, Wang, Li, Leach, Jan E, Verdier, Valérie, Cunnac, Sébastien, Bogdanove, Adam J, Koebnik, Ralf, Hutin, Mathilde, Szurek, Boris

“…Most Xanthomonas species translocate Transcription Activator-Like (TAL) effectors into plant cells where they function like plant transcription factors via a…”
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Using horizontal cooperation concepts in integrated routing and facility‐location decisions by Quintero‐Araujo, Carlos L., Gruler, Aljoscha, Juan, Angel A., Faulin, Javier

“…In a global and competitive economy, efficient supply networks are essential for modern enterprises. Horizontal cooperation (HC) concepts represent a promising…”
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CDR-H3 loop ensemble in solution - conformational selection upon antibody binding by Fernández-Quintero, Monica L, Kraml, Johannes, Georges, Guy, Liedl, Klaus R

“…We analyzed pairs of protein-binding, peptide-binding and hapten-binding antibodies crystallized as complex and in the absence of the antigen with and without…”
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Implementation of the Freely Jointed Chain Model to Assess Kinetics and Thermodynamics of Thermosensitive Coil–Globule Transition by Markov States by Quoika, Patrick K, Fernández-Quintero, Monica L, Podewitz, Maren, Hofer, Florian, Liedl, Klaus R

“…We revived and implemented a method developed by Kuhn in 1934, originally only published in German, that is, the so-called “freely jointed chain” model. This…”
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Challenges in antibody structure prediction by Fernández-Quintero, Monica L., Kokot, Janik, Waibl, Franz, Fischer, Anna-Lena M., Quoika, Patrick K., Deane, Charlotte M., Liedl, Klaus R.

“…Advances in structural biology and the exponential increase in the amount of high-quality experimental structural data available in the Protein Data Bank has…”
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The nature of spin excitations in the one-third magnetization plateau phase of Ba3CoSb2O9 by Kamiya, Y., Ge, L., Hong, Tao, Qiu, Y., Quintero-Castro, D. L., Lu, Z., Cao, H. B., Matsuda, M., Choi, E. S., Batista, C. D., Mourigal, M., Zhou, H. D., Ma, J.

“…Magnetization plateaus in quantum magnets—where bosonic quasiparticles crystallize into emergent spin superlattices—are spectacular yet simple examples of…”
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On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality by Fernández‐Quintero, Monica L., Guarnera, Enrico, Musil, Djordje, Pekar, Lukas, Sellmann, Carolin, Freire, Filipe, Sousa, Raquel L., Santos, Sandra P., Freitas, Micael C., Bandeiras, Tiago M., Silva, Margarida M. S., Loeffler, Johannes R., Ward, Andrew B., Harwardt, Julia, Zielonka, Stefan, Evers, Andreas

“…The humanization of camelid‐derived variable domain heavy chain antibodies (VHHs) poses challenges including immunogenicity, stability, and potential reduction…”
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VH‐VL interdomain dynamics observed by computer simulations and NMR by Fernández‐Quintero, Monica L., Hoerschinger, Valentin J., Lamp, Leonida M., Bujotzek, Alexander, Georges, Guy, Liedl, Klaus R.

“…The relative orientation of the two variable domains, VH and VL, influences the shape of the antigen binding site, that is, the paratope, and is essential to…”
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Conformational Ensembles of Antibodies Determine Their Hydrophobicity by Waibl, Franz, Fernández-Quintero, Monica L., Kamenik, Anna S., Kraml, Johannes, Hofer, Florian, Kettenberger, Hubert, Georges, Guy, Liedl, Klaus R.

“…A major challenge in the development of antibody biotherapeutics is their tendency to aggregate. One root cause for aggregation is exposure of hydrophobic…”
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The Structural Flexibility of PR-10 Food Allergens by Führer, Sebastian, Unterhauser, Jana, Zeindl, Ricarda, Eidelpes, Reiner, Fernández-Quintero, Monica L., Liedl, Klaus R., Tollinger, Martin

“…PR-10 proteins constitute a major cause of food allergic reactions. Birch-pollen-related food allergies are triggered by the immunologic cross-reactivity of…”
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