Search Results - "Quintavalle, Manuela"

Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function by Hall, Ignacio Fernando, Climent, Montserrat, Quintavalle, Manuela, Farina, Floriana Maria, Schorn, Tilo, Zani, Stefania, Carullo, Pierluigi, Kunderfranco, Paolo, Civilini, Efrem, Condorelli, Gianluigi, Elia, Leonardo

“…RATIONALE:microRNAs (miRNAs) modulate gene expression by repressing translation of targeted genes. Previous work has established a role for miRNAs in…”
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miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases by Farina, Floriana Maria, Hall, Ignacio Fernando, Serio, Simone, Zani, Stefania, Climent, Montserrat, Salvarani, Nicolò, Carullo, Pierluigi, Civilini, Efrem, Condorelli, Gianluigi, Elia, Leonardo, Quintavalle, Manuela

“…MicroRNAs (miRNAs, miRs) are small noncoding RNAs that modulate gene expression by negatively regulating translation of target genes. Although the role of…”
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MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro by Quintavalle, Manuela, Elia, Leonardo, Condorelli, Gianluigi, Courtneidge, Sara A

“…Smooth muscle cell (SMC) plasticity plays an important role during development and in vascular pathologies such as atherosclerosis and restenosis. It was…”
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UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease by Elia, Leonardo, Kunderfranco, Paolo, Carullo, Pierluigi, Vacchiano, Marco, Farina, Floriana Maria, Hall, Ignacio Fernando, Mantero, Stefano, Panico, Cristina, Papait, Roberto, Condorelli, Gianluigi, Quintavalle, Manuela

“…Adult vascular smooth muscle cells (VSMCs) dedifferentiate in response to extracellular cues such as vascular damage and inflammation. Dedifferentiated VSMCs…”
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Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions by ELIA, Leonardo, CONTU, Riccardo, CONDORELLI, Gianluigi, QUINTAVALLE, Manuela, VARRONE, Francesca, CHIMENTI, Cristina, RUSSO, Matteo Antonio, CIMINO, Vincenzo, DE MARINIS, Laura, FRUSTACI, Andrea, CATALUCCI, Daniele

“…MicroRNAs (miRNAs/miRs) are small conserved RNA molecules of 22 nucleotides that negatively modulate gene expression primarily through base paring to the 3'…”
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Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation by Diaz, Begoña, Shani, Gidon, Pass, Ian, Anderson, Diana, Quintavalle, Manuela, Courtneidge, Sara A

“…Invadopodia are actin-rich membrane protrusions of cancer cells that facilitate pericellular proteolysis and invasive behavior. We show here that reactive…”
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A cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasion by Quintavalle, Manuela, Elia, Leonardo, Price, Jeffrey H, Heynen-Genel, Susanne, Courtneidge, Sara A

“…Acquisition of invasive cell behavior underlies tumor progression and metastasis. To further define the molecular mechanisms underlying invasive behavior, we…”
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Epigenetics and Vascular Diseases: Influence of Non-coding RNAs and Their Clinical Implications by Elia, Leonardo, Quintavalle, Manuela

“…Epigenetics refers to heritable mechanisms able to modulate gene expression that do not involve alteration of the genomic DNA sequence. Classically, mechanisms…”
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The α Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation by Quintavalle, Manuela, Sambucini, Sonia, Di Pietro, Chiara, De Francesco, Raffaele, Neddermann, Petra

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture by NEDDERMANN, Petra, QUINTAVALLE, Manuela, DI PIETRO, Chiara, CLEMENTI, Angelica, CERRETANI, Mauro, ALTAMURA, Sergio, BARTHOLOMEW, Linda, DE FRANCESCO, Raffaele

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TGFβ Triggers miR-143/145 Transfer From Smooth Muscle Cells to Endothelial Cells, Thereby Modulating Vessel Stabilization by Climent, Montserrat, Quintavalle, Manuela, Miragoli, Michele, Chen, Ju, Condorelli, Gianluigi, Elia, Leonardo

“…RATIONALE:The miR-143/145 cluster is highly expressed in smooth muscle cells (SMCs), where it regulates phenotypic switch and vascular homeostasis. Whether it…”
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The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway by Farina, Floriana Maria, Serio, Simone, Hall, Ignacio Fernando, Zani, Stefania, Cassanmagnago, Giada Andrea, Climent, Montserrat, Civilini, Efrem, Condorelli, Gianluigi, Quintavalle, Manuela, Elia, Leonardo

“…Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by methyltransferase disruptor of telomeric silencing 1-like (DOT1L). We aimed…”
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Circular RNAs and heart failure: new players for an old disease by Elia, Leonardo, Quintavalle, Manuela, Condorelli, Gianluigi

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Arterial remodeling and atherosclerosis: miRNAs involvement by Quintavalle, Manuela, Condorelli, Gianluigi, Elia, Leonardo

“…Abstract Cardiometabolic diseases (CMD) (such as atherosclerosis, diabetes, and hypertension) are the primary cause of death and disability in the Western…”
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MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines by Farina, Floriana Maria, Inguscio, Alessandra, Kunderfranco, Paolo, Cortesi, Alice, Elia, Leonardo, Quintavalle, Manuela

“…Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin lymphoma. Despite a favorable therapeutic response to first-line…”
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The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease by Elia, L, Quintavalle, M, Zhang, J, Contu, R, Cossu, L, Latronico, M V G, Peterson, K L, Indolfi, C, Catalucci, D, Chen, J, Courtneidge, S A, Condorelli, G

“…Mechanisms controlling vascular smooth muscle cell (VSMC) plasticity and renewal still remain to be elucidated completely. A class of small RNAs called…”
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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth by Iizuka, Shinji, Quintavalle, Manuela, Navarro, Jose C, Gribbin, Kyle P, Ardecky, Robert J, Abelman, Matthew M, Ma, Chen-Ting, Sergienko, Eduard, Zeng, Fu-Yue, Pass, Ian, Thomas, George V, McWeeney, Shannon K, Hassig, Christian A, Pinkerton, Anthony B, Courtneidge, Sara A

“…Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. In this study, we used our high-content screening…”
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UHRF1 epigenetically orchestrates smooth muscle cell plasticity in arterial disease by Elia, Leonardo, Kunderfranco, Paolo, Carullo, Pierluigi, Vacchiano, Marco, Farina, Floriana Maria, Hall, Ignacio Fernando, Mantero, Stefano, Panico, Cristina, Papait, Roberto, Condorelli, Gianluigi, Quintavalle, Manuela

“…Adult vascular smooth muscle cells (VSMCs) dedifferentiate in response to extracellular cues such as vascular damage and inflammation. Dedifferentiated VSMCs…”
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Hepatitis C Virus NS5A Is a Direct Substrate of Casein Kinase I-α, a Cellular Kinase Identified by Inhibitor Affinity Chromatography Using Specific NS5A Hyperphosphorylation Inhibitors by Quintavalle, Manuela, Sambucini, Sonia, Summa, Vincenzo, Orsatti, Laura, Talamo, Fabio, De Francesco, Raffaele, Neddermann, Petra

“…The hepatitis C virus encodes a single polyprotein that is processed by host and viral proteases to yield at least 10 mature viral proteins. The nonstructural…”
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Abstract SY02-04: Regulation of invadopodia formation and cancer cell invasion by Blouw, Barbara, Buschman, Matt, Cejudo-Martin, Pilar, Diaz, Begoña, Gould, Christine, Murphy, Danielle, Quintavalle, Manuela, Heynen, Susanne, Azimi, Behrad, Price, Jeff, Courtneidge, Sara A.

“…Cell invasion plays a central role in a wide variety of biological phenomena, and is the cause of tumor growth and metastasis. Understanding the biochemical…”
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