Search Results - "Quintas, M."

In Vitro Activity of Delafloxacin and Microbiological Response against Fluoroquinolone-Susceptible and Nonsusceptible Staphylococcus aureus Isolates from Two Phase 3 Studies of Acute Bacterial Skin and Skin Structure Infections by McCurdy, S, Lawrence, L, Quintas, M, Woosley, L, Flamm, R, Tseng, C, Cammarata, S

“…Delafloxacin is an investigational anionic fluoroquinolone antibiotic with broad-spectrum activity, including activity against Gram-positive organisms,…”
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Efficacy and safety of delafloxacin compared with vancomycin plus aztreonam for acute bacterial skin and skin structure infections: a Phase 3, double-blind, randomized study by Pullman, J, Gardovskis, J, Farley, B, Sun, E, Quintas, M, Lawrence, L, Ling, R, Cammarata, S

“…Delafloxacin is an investigational anionic fluoroquinolone in development for oral or intravenous administration for the treatment of infections caused by…”
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The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence by Kinoshita, Paula F, Leite, Jacqueline A, Orellana, Ana Maria M, Vasconcelos, Andrea R, Quintas, Luis E M, Kawamoto, Elisa M, Scavone, Cristoforo

“…Decreased Na(+), K(+)-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three…”
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Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study by Azalim, Pedro, do Monte, Fernando M., Rendeiro, Mariana Manzano, Liu, Xiaofan, O'Doherty, George A., Fontes, Carlos Frederico, Leitão, Suzana Guimarães, Quintas, Luis Eduardo M., Noël, François

“…[Display omitted] There is a renewed interest in the Na+/K+-ATPase (NKA, EC 3.6.3.9) either as a target for new therapeutic uses or for understanding the…”
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Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides by Amaral, Luciana S, Martins Ferreira, Jainne, Predes, Danilo, Abreu, José Garcia, Noël, François, Quintas, Luis Eduardo M

“…Bufadienolides are cardiotonic steroids (CTS) identified in mammals. Besides Na⁺/K⁺-ATPase inhibition, they activate signal transduction via protein⁻protein…”
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Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na+/K+-ATPase activity by Perera Córdova, Wilmer H., Leitão, Suzana Guimarães, Cunha-Filho, Geraldino, Bosch, Roberto Alonso, Alonso, Isel Pascual, Pereda-Miranda, Rogelio, Gervou, Rodrigo, Touza, Natália Araújo, Quintas, Luis Eduardo M., Noël, François

“…Parotoid gland secretions of toad species are a vast reservoir of bioactive molecules with a wide range of biological properties. Herein, for the first time,…”
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Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase by Cai, Ting, Wang, Haojie, Chen, Yiliang, Liu, Lijun, Gunning, William T, Quintas, Luis Eduardo M, Xie, Zi-Jian

“…Here, we show that the Na/K-ATPase interacts with caveolin-1 (Cav1) and regulates Cav1 trafficking. Graded knockdown of Na/K-ATPase decreases the plasma…”
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21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions by Rocha, Sayonarah C, Pessoa, Marco T C, Neves, Luiza D R, Alves, Silmara L G, Silva, Luciana M, Santos, Herica L, Oliveira, Soraya M F, Taranto, Alex G, Comar, Moacyr, Gomes, Isabella V, Santos, Fabio V, Paixão, Natasha, Quintas, Luis E M, Noël, François, Pereira, Antonio F, Tessis, Ana C S C, Gomes, Natalia L S, Moreira, Otacilio C, Rincon-Heredia, Ruth, Varotti, Fernando P, Blanco, Gustavo, Villar, Jose A F P, Contreras, Rubén G, Barbosa, Leandro A

“…Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also…”
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Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies by Leite, Jacqueline Alves, Pôças, Elisa, Maia, Gisele Silva, Barbosa, Leandro, Quintas, Luis Eduardo M., Kawamoto, Elisa Mitiko, Silva, Maria Luiza Correia da, Scavone, Cristoforo, de Carvalho, Luciana E. Drumond

“…The Na + /K + -ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more…”
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Assessment of bariatric surgery efficacy on Obstructive Sleep Apnea (OSA) by Quintas-Neves, M, Preto, J, Drummond, M

“…AbstractA worldwide rise in weight and obesity is taking place, associated with an increase in several comorbid conditions, such as Obstructive Sleep Apnea…”
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Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations by Noël, François, Azalim, Pedro, do Monte, Fernando M., Quintas, Luis Eduardo M., Katz, Adriana, Karlish, Steven J.D.

“…Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is…”
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A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization by Teixeira-Cruz, Jhonatha Mota, Strauch, Marcelo Abrahão, Monteiro-Machado, Marcos, Tavares-Henriques, Matheus Silva, de Moraes, João Alfredo, Ribeiro da Cunha, Luís Eduardo, Ferreira, Jr, Rui Seabra, Barraviera, Benedito, Quintas, Luis Eduardo M, Melo, Paulo A

“…Massive, Africanized honeybee attacks have increased in Brazil over the years. Humans and animals present local and systemic effects after envenomation, and…”
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The Complementary Role of CT Perfusion and Transcranial Doppler in the Assessment of Delayed Cerebral Ischemia after Aneurysmal SAH by Quintas-Neves, M

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Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines by Rodrigues-Mascarenhas, Sandra, Feijó, Priscilla R. O., Alves, Anne Kaliery De Abreu, Galvão, José Guilherme Marques, Lima, Éssia de A., Cavalcante-Silva, Luiz Henrique Agra, Carvalho, Deyse C. M., Quintas, Luís E. M.

“…Cardiotonic steroids, such as ouabain and digoxin, are known to bind to Na+/K+-ATPase and to promote several biological activities, including anti-inflammatory…”
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Dietary intake and cognitive function in a group of elderly people by Ortega, RM, Requejo, AM, Andrés, P, López-Sobaler, AM, Quintas, ME, Redondo, MR, Navia, B, Rivas, T

“…Associations between dietary intake and cognitive performance were examined in 260 elderly people aged 65-90 y who were free of significant cognitive…”
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COVID-19 Related Central Nervous System Vasculopathy: Beyond Vasculitis by Quintas-Neves, M

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Recalling the Usefulness of Conebeam CT in Temporal Bone Imaging: Higher Resolution with Lower Radiation Dose by Quintas-Neves, M, Saraiva, J

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LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain by Lima, Cleverton K F, Silva, Rafael M, Lacerda, Renata B, Santos, Bruna L R, Silva, Rafaela V, Amaral, Luciana S, Quintas, Luís E M, Fraga, Carlos A M, Barreiro, Eliezer J, Guimaraes, Marília Z P, Miranda, Ana L P

“…LASSBio-1135 is an imidazo[1,2-a]pyridine derivative with high efficacy in screening models of nociception and inflammation, presumed as a weak COX-2…”
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Increased endothelial cell-leukocyte interaction in murine schistosomiasis: possible priming of endothelial cells by the disease by Oliveira, Suellen D S, Quintas, Luis E M, Amaral, Luciana S, Noël, François, Farsky, Sandra H, Silva, Claudia L M

“…Schistosomiasis is an intravascular parasitic disease associated with inflammation. Endothelial cells control leukocyte transmigration and vascular…”
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Contribution to hydrological modelling of small Amazonian catchments: application of rainfall–runoff models to simulate flow duration curves by Blanco, C.J.C, Santos, S.S.M, Quintas, M.C, Vinagre, M.V.A, Mesquita, A.L.A

“…The objective of this study is to analyse three rainfall–runoff hydrological models applied in two small catchments in the Amazon region to simulate flow…”
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