Search Results - "Quintanova, Catarina"
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Claudin-10a Deficiency Shifts Proximal Tubular Cl - Permeability to Cation Selectivity via Claudin-2 Redistribution
Published in Journal of the American Society of Nephrology (01-04-2022)“…The tight junction proteins claudin-2 and claudin-10a form paracellular cation and anion channels, respectively, and are expressed in the proximal tubule…”
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2
Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking
Published in Journal of the American Society of Nephrology (01-05-2019)“…Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into…”
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3
Claudin-10b Role in the Basolateral Infoldings of the Thick Ascending Limb: TH-PO329
Published in Journal of the American Society of Nephrology (01-11-2022)Get full text
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Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole hybrids as multi-targeted compounds against Alzheimer’s disease
Published in Bioorganic & medicinal chemistry (01-08-2013)“…Hybrid compounds based on a suitable conjugation of tacrine and benzothiazole (BTA) moieties were designed and prepared. Their activity as inhibitors of AChE…”
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5
Phosphorylated claudin-16 interacts with Trpv5 and regulates transcellular calcium transport in the kidney
Published in Proceedings of the National Academy of Sciences - PNAS (17-09-2019)“…Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC)was previously considered to be a paracellular channelopathy caused by mutations in the…”
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6
Unrecognized role of claudin‐10b in basolateral membrane infoldings of the thick ascending limb
Published in Annals of the New York Academy of Sciences (01-11-2022)“…Claudin‐10b is an important component of the tight junction in the thick ascending limb (TAL) of Henle's loop and allows paracellular sodium transport. In…”
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New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease
Published in Chemical biology & drug design (01-01-2016)“…Alzheimer's disease (AD) is a devastating age‐dependent neurodegenerative disorder. The main hallmarks are impairment of cholinergic system and accumulation in…”
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Multifunctional iron-chelators with protective roles against neurodegenerative diseases
Published in Dalton transactions : an international journal of inorganic chemistry (07-05-2013)“…The multifactorial nature of Alzheimer's disease (AD), and the absence of a disease modifying drug, makes the development of new multifunctional drugs an…”
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Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles
Published in Journal of inorganic biochemistry (01-10-2015)“…The complexity and multifactorial nature of neurodegenerative diseases turn quite difficult the development of adequate drugs for their treatment. Multi-target…”
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Design, synthesis and neuroprotective evaluation of novel tacrineabenzothiazole hybrids as multi-targeted compounds against Alzheimeras disease
Published in Bioorganic & medicinal chemistry (01-08-2013)“…Alzheimeras disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug…”
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11
Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics
Published in Function (Oxford, England) (01-01-2020)“…The revolution of the omics technologies has enabled profiling of the molecules of any sample. However, the heterogeneity of the kidney with highly specialized…”
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Novos Compostos híbridos Com Potencial ação Neuroprotetora
Published 01-01-2013“…A doença de Alzheimer (AD) é uma doença neurodegenerativa progressiva e é considerada a forma mais comum de demência na população idosa. Atualmente, apesar dos…”
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Dissertation