Search Results - "Quintana, Jeremy M."

Extended Pharmacokinetics Improve Site-Specific Prodrug Activation Using Radiation by Quintana, Jeremy M., Kang, Mikyung, Hu, Huiyu, Ng, Thomas S. C., Wojtkiewicz, Gregory R., Scott, Ella, Parangi, Sareh, Schuemann, Jan, Weissleder, Ralph, Miller, Miles A.

“…Radiotherapy is commonly used to treat cancer, and localized energy deposited by radiotherapy has the potential to chemically uncage prodrugs; however, it has…”
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Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release by Quintana, Jeremy M., Arboleda, David, Hu, Huiyu, Scott, Ella, Luthria, Gaurav, Pai, Sara, Parangi, Sareh, Weissleder, Ralph, Miller, Miles A.

“…Conjugation of therapeutic payloads to biologics including antibodies and albumin can enhance the selectively of drug delivery to solid tumors. However,…”
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Scission-Enhanced Molecular Imaging (SEMI) by Quintana, Jeremy M., Carlson, Jonathan C. T., Scott, Ella, Ng, Thomas S. C., Miller, Miles A., Weissleder, Ralph

“…Positron emission tomography (PET) imaging methods have advanced our understanding of human biology, while targeted radiotherapeutic drug treatments are now…”
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Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin-Drug Conjugate Response by Hu, Huiyu, Ng, Thomas S C, Kang, Mikyung, Scott, Ella, Li, Ran, Quintana, Jeremy M, Matvey, Dylan, Vantaku, Venkata R, Weissleder, Ralph, Parangi, Sareh, Miller, Miles A

“…Oncogene-driven macropinocytosis fuels nutrient scavenging in some cancer types, yet whether this occurs in thyroid cancers with prominent MAPK-ERK and PI3K…”
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Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation by Chang, Charles A., Akinbobuyi, Babatope, Quintana, Jeremy M., Yoshimatsu, Gumpei, Naziruddin, Bashoo, Kane, Robert R.

“…The systemic administration of immunosuppressive and anti-inflammatory drugs is routinely employed in organ transplantation to minimize graft rejection and…”
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Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study by Gayler, Kevin M., Quintana, Jeremy M., Mattke, Jordan, Plunk, Michael A., Kostyo, Jessica H., Karunananthan, Johann W., Nguyen, Harold, Shuda, Mina, Ferreira, Liam D., Baker, Hannah, Stinchcomb, Alexandra L., Sharina, Iraida, Kane, Robert R., Martin, Emil

“…Previous studies demonstrated that anti-hyperlipidemic drug gemfibrozil acts as NO- and heme-independent activator of NO receptor soluble guanylyl cyclase. A…”
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Design and Catalyzed Activation of Mycophenolic Acid Prodrugs by Plunk, Michael A, Quintana, Jeremy M, Darden, Carly M, Lawrence, Michael C, Naziruddin, Bashoo, Kane, Robert R

“…Mycophenolic acid (MPA) and its morpholino ester prodrug mycophenolate mofetil (MMF) are widely used in solid organ transplantation. These drugs prevent…”
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Synthesis and immunostimulatory activity of substituted TLR7 agonists by Akinbobuyi, Babatope, Wang, Lei, Upchurch, Katherine C., Byrd, Matthew R., Chang, Charles A., Quintana, Jeremy M., Petersen, Rachel E., Seifert, Zacharie J., Boquin, José R., Oh, SangKon, Kane, Robert R.

“…[Display omitted] Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds,…”
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Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response by Hu, Huiyu, Ng, Thomas S.C., Kang, Mikyung, Scott, Ella, Li, Ran, Quintana, Jeremy M., Matvey, Dylan, Vantaku, Venkata R., Weissleder, Ralph, Parangi, Sareh, Miller, Miles A.

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Abstract 3067: Constitutive macropinocytosis in BRAFV600E thyroid cancer promotes response to a serum-albumin conjugate of monomethyl auristatin E by Hu, Huiyu, Ng, Thomas S., Kang, Mikyung, Scott, Ella, Li, Ran, Quintana, Jeremy M., Matvey, Dylan, Vantaku, Venkata R., Weissleder, Ralph, Parangi, Sareh, Miller, Miles A.

“…Abstract Background: The non-specific uptake of extracellular materials through macropinocytosis can fuel tumor growth and survival, and is especially studied…”
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Synthesis and Bioconjugation of Small Organic Molecules for Immunomodulation by Quintana, Jeremy M

“…Over the past two decades, a number of immunological pathways have been identified which recognize a wide range of pathogen-associated molecular patterns…”
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