Search Results - "Quinn, T. Alexander"

Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm by Quinn, T Alexander, Kohl, Peter

“…The heart is vital for biological function in almost all chordates, including humans. It beats continually throughout our life, supplying the body with oxygen…”
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Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans by MacDonald, Eilidh A, Rose, Robert A, Quinn, T Alexander

“…The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for…”
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Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics by Quinn, T. Alexander, Camelliti, Patrizia, Rog-Zielinska, Eva A., Siedlecka, Urszula, Poggioli, Tommaso, O’Toole, Eileen T., Knöpfel, Thomas, Kohl, Peter

“…Electrophysiological studies of excitable organs usually focus on action potential (AP)-generating cells, whereas nonexcitable cells are generally considered…”
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Electrophysiological properties of computational human ventricular cell action potential models under acute ischemic conditions by Dutta, Sara, Mincholé, Ana, Quinn, T. Alexander, Rodriguez, Blanca

“…Acute myocardial ischemia is one of the main causes of sudden cardiac death. The mechanisms have been investigated primarily in experimental and computational…”
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Rabbit models of cardiac mechano-electric and mechano-mechanical coupling by Quinn, T. Alexander, Kohl, Peter

“…Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as ‘the…”
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Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm by Muszkiewicz, Anna, Britton, Oliver J., Gemmell, Philip, Passini, Elisa, Sánchez, Carlos, Zhou, Xin, Carusi, Annamaria, Quinn, T. Alexander, Burrage, Kevin, Bueno-Orovio, Alfonso, Rodriguez, Blanca

“…Physiological variability manifests itself via differences in physiological function between individuals of the same species, and has crucial implications in…”
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The importance of non-uniformities in mechano-electric coupling for ventricular arrhythmias by Quinn, T. Alexander

“…Cardiac mechanical and electrical activities are tightly linked through an intra-cardiac regulatory loop (mechano-electric coupling). This connection is…”
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What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm by MacDonald, Eilidh A, Quinn, T Alexander

“…The rhythmic and spontaneously generated electrical excitation that triggers the heartbeat originates in the sinoatrial node (SAN). SAN automaticity has been…”
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Zebrafish heart as a model to study the integrative autonomic control of pacemaker function by Stoyek, Matthew R, Quinn, T Alexander, Croll, Roger P, Smith, Frank M

“…The cardiac pacemaker sets the heart's primary rate, with pacemaker discharge controlled by the autonomic nervous system through intracardiac ganglia. A…”
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Mechanically Induced Ectopy via Stretch-Activated Cation-Nonselective Channels Is Caused by Local Tissue Deformation and Results in Ventricular Fibrillation if Triggered on the Repolarization Wave Edge (Commotio Cordis) by Quinn, T Alexander, Jin, Honghua, Lee, Peter, Kohl, Peter

“…BACKGROUND—External chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVEM) and, rarely, ventricular…”
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Seeing the Light: The Use of Zebrafish for Optogenetic Studies of the Heart by Baillie, Jonathan S, Stoyek, Matthew R, Quinn, T Alexander

“…Optogenetics, involving the optical measurement and manipulation of cellular activity with genetically encoded light-sensitive proteins ("reporters" and…”
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The in vivo study of cardiac mechano-electric and mechano-mechanical coupling during heart development in zebrafish by Baillie, Jonathan S, Gendernalik, Alex, Garrity, Deborah M, Bark, Jr, David, Quinn, T Alexander

“…In the adult heart, acute adaptation of electrical and mechanical activity to changes in mechanical load occurs feedback processes known as "mechano-electric…”
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Age-associated changes in electrical function of the zebrafish heart by Stoyek, Matthew R., Rog-Zielinska, Eva A., Quinn, T. Alexander

“…Age-associated changes in cardiac structure and function have been observed from the molecular to whole organ level in humans and mammalian models…”
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Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region by Abu Nahia, Karim, Migdał, Maciej, Quinn, T. Alexander, Poon, Kar-Lai, Łapiński, Maciej, Sulej, Agata, Liu, Jiandong, Mondal, Shamba S., Pawlak, Michał, Bugajski, Łukasz, Piwocka, Katarzyna, Brand, Thomas, Kohl, Peter, Korzh, Vladimir, Winata, Cecilia

“…The atrioventricular canal (AVC) is the site where key structures responsible for functional division between heart regions are established, most importantly,…”
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Population of computational rabbit-specific ventricular action potential models for investigating sources of variability in cellular repolarisation by Gemmell, Philip, Burrage, Kevin, Rodriguez, Blanca, Quinn, T Alexander

“…Variability is observed at all levels of cardiac electrophysiology. Yet, the underlying causes and importance of this variability are generally unknown, and…”
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Sinoatrial Node Structure, Mechanics, Electrophysiology and the Chronotropic Response to Stretch in Rabbit and Mouse by MacDonald, Eilidh A, Madl, Josef, Greiner, Joachim, Ramadan, Ahmed F, Wells, Sarah M, Torrente, Angelo G, Kohl, Peter, Rog-Zielinska, Eva A, Quinn, T Alexander

“…The rhythmic electrical activity of the heart's natural pacemaker, the sinoatrial node (SAN), determines cardiac beating rate (BR). SAN electrical activity is…”
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Altered Calcium Handling and Ventricular Arrhythmias in Acute Ischemia by Baumeister, Peter, Quinn, T. Alexander

“…Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden cardiac death (SCD). The electrophysiological changes involved have…”
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Drivers of Sinoatrial Node Automaticity in Zebrafish: Comparison With Mechanisms of Mammalian Pacemaker Function by Stoyek, Matthew R, MacDonald, Eilidh A, Mantifel, Melissa, Baillie, Jonathan S, Selig, Bailey M, Croll, Roger P, Smith, Frank M, Quinn, T Alexander

“…Cardiac excitation originates in the sinoatrial node (SAN), due to the automaticity of this distinct region of the heart. SAN automaticity is the result of a…”
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Ischemia Enhances the Acute Stretch-Induced Increase in Calcium Spark Rate in Ventricular Myocytes by Cameron, Breanne A, Kai, Hiroaki, Kaihara, Keiko, Iribe, Gentaro, Quinn, T Alexander

“…In ventricular myocytes, spontaneous release of calcium (Ca ) from the sarcoplasmic reticulum via ryanodine receptors ("Ca sparks") is acutely increased by…”
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Cardiac Electrophysiological Effects of Light-Activated Chloride Channels by Kopton, Ramona A, Baillie, Jonathan S, Rafferty, Sara A, Moss, Robin, Zgierski-Johnston, Callum M, Prykhozhij, Sergey V, Stoyek, Matthew R, Smith, Frank M, Kohl, Peter, Quinn, T Alexander, Schneider-Warme, Franziska

“…During the last decade, optogenetics has emerged as a paradigm-shifting technique to monitor and steer the behavior of specific cell types in excitable…”
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