Search Results - "Quinn, Jeanne M"
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α-catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration
Published in Molecular biology of the cell (01-05-2024)“…α-catenin (α-cat) displays force-dependent unfolding and binding to actin filaments through direct and indirect means, but features of adherens junction…”
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Aggregation Profiling of C9orf72 Dipeptide Repeat Proteins Transgenically Expressed in Drosophila melanogaster Using an Analytical Ultracentrifuge Equipped with Fluorescence Detection
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…The recent development of a fluorescence detection system for the analytical ultracentrifuge has allowed for the characterization of protein size and…”
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Size Analysis of C9orf72 Dipeptide Repeat Proteins Expressed in Drosophila melanogaster Using Semidenaturing Detergent Agarose Gel Electrophoresis
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…This chapter supplements Chapter 6 on sample preparation and analysis using an analytical ultracentrifuge with fluorescence detection. In this related chapter,…”
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Therapeutic Inhibition of the Receptor Tyrosine Kinase AXL Improves Sensitivity to Platinum and Taxane in Ovarian Cancer
Published in Molecular cancer therapeutics (01-02-2019)“…Ovarian cancer, one of the deadliest malignancies in female cancer patients, is characterized by recurrence and poor response to cytotoxic chemotherapies…”
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Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer
Published in Molecular cancer therapeutics (01-12-2017)“…Uterine serous cancer (USC) is aggressive, and the majority of recurrent cases are chemoresistant. Because the receptor tyrosine kinase AXL promotes invasion…”
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p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts
Published in Scientific reports (18-03-2019)“…Ovarian and uterine serous cancers are extremely lethal diseases that often present at an advanced stage. The late-stage diagnosis of these patients results in…”
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SQ1274, a novel microtubule inhibitor, inhibits ovarian and uterine cancer cell growth
Published in Gynecologic oncology (01-11-2018)“…Paclitaxel, a microtubule inhibitor, is subject to tumor resistance while treating high-grade serous ovarian and uterine cancer. This study aims to directly…”
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Uncovering protein-protein interactions through a team-based undergraduate biochemistry course
Published in PLoS biology (01-11-2017)“…How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving…”
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Multiple Bacteriophage Selection Strategies for Improved Affinity of a Peptide Targeting ERBB2
Published in International journal of peptide research and therapeutics (01-12-2015)“…Due to the heterogeneity of ERBB2-expression between tumors and over the course of treatment, a non-invasive molecular imaging agent is needed to accurately…”
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