Search Results - "Quinn, J."

The re-emergence of natural products for drug discovery in the genomics era by Harvey, Alan L., Edrada-Ebel, RuAngelie, Quinn, Ronald J.

“…Key Points Natural products continue to be an important source of leads for new medicines, despite reduced interest from large pharmaceutical companies…”
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Recent developments in carbon nanomaterial sensors by Baptista, Frederico R, Belhout, S A, Giordani, S, Quinn, S J

“…Carbon nanomaterials are among the most broadly discussed, researched and applied of synthetic nanomaterials. The structural diversity of these materials…”
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A numerical method for a nonlinear singularly perturbed interior layer problem using an approximate layer location by Quinn, J.

“…A class of nonlinear singularly perturbed interior layer problems is examined in this paper. Solutions exhibit an interior layer at an a priori unknown…”
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Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging by Bartelmess, J, Quinn, S J, Giordani, S

“…Carbon based nanomaterials have emerged over the last few years as important agents for biomedical fluorescence and Raman imaging applications. These…”
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Spectrally resolved fast transient brain states in electrophysiological data by Vidaurre, Diego, Quinn, Andrew J., Baker, Adam P., Dupret, David, Tejero-Cantero, Alvaro, Woolrich, Mark W.

“…The brain is capable of producing coordinated fast changing neural dynamics across multiple brain regions in order to adapt to rapidly changing environments…”
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Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts by Quinn, Jeffrey J, Jones, Matthew G, Okimoto, Ross A, Nanjo, Shigeki, Chan, Michelle M, Yosef, Nir, Bivona, Trever G, Weissman, Jonathan S

“…Detailed phylogenies of tumor populations can recount the history and chronology of critical events during cancer progression, such as metastatic…”
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Discovering dynamic brain networks from big data in rest and task by Vidaurre, Diego, Abeysuriya, Romesh, Becker, Robert, Quinn, Andrew J., Alfaro-Almagro, Fidel, Smith, Stephen M., Woolrich, Mark W.

“…Brain activity is a dynamic combination of the responses to sensory inputs and its own spontaneous processing. Consequently, such brain activity is…”
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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle by Frederick, David W., Loro, Emanuele, Liu, Ling, Davila, Antonio, Chellappa, Karthikeyani, Silverman, Ian M., Quinn, William J., Gosai, Sager J., Tichy, Elisia D., Davis, James G., Mourkioti, Foteini, Gregory, Brian D., Dellinger, Ryan W., Redpath, Philip, Migaud, Marie E., Nakamaru-Ogiso, Eiko, Rabinowitz, Joshua D., Khurana, Tejvir S., Baur, Joseph A.

“…NAD is an obligate co-factor for the catabolism of metabolic fuels in all cell types. However, the availability of NAD in several tissues can become limited…”
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Advances in half-Heusler alloys for thermoelectric power generation by Quinn, Robert J, Bos, Jan-Willem G

“…Half-Heusler alloys are leading candidate materials for large scale thermoelectric power generation. In the past decade, substantial improvements have been…”
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Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks by Vidaurre, Diego, Hunt, Laurence T., Quinn, Andrew J., Hunt, Benjamin A. E., Brookes, Matthew J., Nobre, Anna C., Woolrich, Mark W.

“…Frequency-specific oscillations and phase-coupling of neuronal populations are essential mechanisms for the coordination of activity between brain areas during…”
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Rival framings: A framework for discovering how problem formulation uncertainties shape risk management trade‐offs in water resources systems by Quinn, J. D., Reed, P. M., Giuliani, M., Castelletti, A.

“…Managing water resources systems requires coordinated operation of system infrastructure to mitigate the impacts of hydrologic extremes while balancing…”
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PINK1/PARKIN signalling in neurodegeneration and neuroinflammation by Quinn, Peter M J, Moreira, Paula I, Ambrósio, António Francisco, Alves, C Henrique

“…Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's…”
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Production of l-valine from metabolically engineered Corynebacterium glutamicum by Wang, Xiaoyuan, Zhang, Hailing, Quinn, Peter J.

“…l -Valine is one of the three branched-chain amino acids (valine, leucine, and isoleucine) essential for animal health and important in metabolism; therefore,…”
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mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion by Quinn, 3rd, William J, Wan, Min, Shewale, Swapnil V, Gelfer, Rebecca, Rader, Daniel J, Birnbaum, Morris J, Titchenell, Paul M

“…Liver triacylglycerol (TAG) synthesis and secretion are closely linked to nutrient availability. After a meal, hepatic TAG formation from fatty acids is…”
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Natural products as lead structures: chemical transformations to create lead-like libraries by Pascolutti, Mauro, Quinn, Ronald J.

“…•Twenty-four libraries generated using natural products as guiding structures were analyzed.•The variation of two main lead-like descriptors (MW, logP) within…”
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Elicitation of secondary metabolism in actinomycetes by Abdelmohsen, Usama Ramadan, Grkovic, Tanja, Balasubramanian, Srikkanth, Kamel, Mohamed Salah, Quinn, Ronald J., Hentschel, Ute

“…Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that…”
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Relative Hyperglycemia, a Marker of Critical Illness: Introducing the Stress Hyperglycemia Ratio by Roberts, Gregory W, Quinn, Stephen J, Valentine, Nyoli, Alhawassi, Tariq, O'Dea, Hazel, Stranks, Stephen N, Burt, Morton G, Doogue, Matthew P

“…Context: Hyperglycemia in hospitalized patients is associated with increased morbidity and mortality. Objective: We examined whether critical illness is more…”
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Time and experience are independent determinants of representational drift in CA1 by Lee, J. Quinn, Brandon, Mark P.

“…In this issue of Neuron, Khatib et al.1 and Geva et al.2 present complementary and breakthrough discoveries demonstrating that elapsed time and active…”
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Renal Catheter Ablation in Hypertension by Quinn, MJ

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Native Mass Spectrometry in Fragment-Based Drug Discovery by Pedro, Liliana, Quinn, Ronald J

“…The advent of native mass spectrometry (MS) in 1990 led to the development of new mass spectrometry instrumentation and methodologies for the analysis of…”
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