Search Results - "Quinn, Deborah A"

Multidetector Computed Tomography for Acute Pulmonary Embolism by Stein, Paul D, Fowler, Sarah E, Goodman, Lawrence R, Gottschalk, Alexander, Hales, Charles A, Hull, Russell D, Leeper, Kenneth V, Popovich, John, Quinn, Deborah A, Sos, Thomas A, Sostman, H. Dirk, Tapson, Victor F, Wakefield, Thomas W, Weg, John G, Woodard, Pamela K

“…Multidetector computed tomographic angiography (CTA) was evaluated alone and with imaging of the pelvic and thigh veins (CTA–CTV). As compared with a reference…”
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Regulation of lung injury and repair by Toll-like receptors and hyaluronan by Noble, Paul W, Jiang, Dianhua, Liang, Jiurong, Fan, Juan, Yu, Shuang, Chen, Suping, Luo, Yi, Prestwich, Glenn D, Mascarenhas, Marcella M, Garg, Hari G, Quinn, Deborah A, Homer, Robert J, Goldstein, Daniel R, Bucala, Richard, Lee, Patty J, Medzhitov, Ruslan

“…Mechanisms that regulate inflammation and repair after acute lung injury are incompletely understood. The extracellular matrix glycosaminoglycan hyaluronan is…”
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Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II Investigators by Stein, Paul D, Woodard, Pamela K, Weg, John G, Wakefield, Thomas W, Tapson, Victor F, Sostman, H Dirk, Sos, Thomas A, Quinn, Deborah A, Leeper, Jr, Kenneth V, Hull, Russell D, Hales, Charles A, Gottschalk, Alexander, Goodman, Lawrence R, Fowler, Sarah E, Buckley, John D

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Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators by Stein, Paul D, Woodard, Pamela K, Weg, John G, Wakefield, Thomas W, Tapson, Victor F, Sostman, H Dirk, Sos, Thomas A, Quinn, Deborah A, Leeper, Jr, Kenneth V, Hull, Russell D, Hales, Charles A, Gottschalk, Alexander, Goodman, Lawrence R, Fowler, Sarah E, Buckley, John D

“…To formulate comprehensive recommendations for the diagnostic approach to patients with suspected pulmonary embolism, based on randomized trials. Diagnostic…”
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Deficiency of the NHE1 Gene Prevents Hypoxia-induced Pulmonary Hypertension and Vascular Remodeling by Yu, Lunyin, Quinn, Deborah A, Garg, Hari G, Hales, Charles A

“…Our previous studies found that Na(+)/H(+) exchanger (NHE) activity played an essential role in pulmonary artery smooth muscle cell (PASMC) proliferation and…”
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Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury by SYRKINA, Olga, JAFARI, Behrouz, HALES, Charles A., QUINN, Deborah A.

“…Background and objective:  Ventilator‐induced lung injury (VILI) leads to airway epithelial cell apoptosis and lung inflammation. High tidal volume ventilation…”
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TLR4 is a negative regulator in noninfectious lung inflammation by Zhao, Hang, Leu, Shaw-Wei, Shi, Liyun, Dedaj, Rejmon, Zhao, Gaofeng, Garg, Hari G, Shen, Lianjun, Lien, Egil, Fitzgerald, Katherine A, Shiedlin, Aviva, Shen, Huahao, Quinn, Deborah A, Hales, Charles A

“…Low m.w. hyaluronan (LMW HA) has been shown to elicit the expression of proinflammatory cytokines and chemokines in various cells in vitro. However, the…”
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High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats by Liu, Yung-Yang, Lee, Cheng-Hung, Dedaj, Rejmon, Zhao, Hang, Mrabat, Hicham, Sheidlin, Aviva, Syrkina, Olga, Huang, Pei-Ming, Garg, Hari G, Hales, Charles A, Quinn, Deborah A

“…Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory…”
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N-Acetylcysteine Inhibits Ventilation-Induced Collagen Accumulation in the Rat Lung by Chen, Chuanxi, Guan, Xiangdong, Quinn, Deborah A., Ouyang, Bin

“…Mechanical ventilation is the most important life supportive therapy for patients with acute respiratory distress syndrome (ARDS). However, increasing evidence…”
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The Role of Hyaluronan Synthase 3 in Ventilator-induced Lung Injury by Bai, Kuan-Jen, Spicer, Andrew P, Mascarenhas, Marcella M, Yu, Lunyin, Ochoa, Cristhiaan D, Garg, Hari G, Quinn, Deborah A

“…We recently found that low-molecular-weight hyaluronan was induced by cyclic stretch in lung fibroblasts and accumulated in lungs from animals with…”
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Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury by Quinn, Deborah A, Moufarrej, Ramzi K, Volokhov, Alexey, Hales, Charles A

“…Pulmonary/Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 The use of positive pressure mechanical…”
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Imatinib in pulmonary arterial hypertension: c-Kit inhibition by Farha, Samar, Dweik, Raed, Rahaghi, Franck, Benza, Raymond, Hassoun, Paul, Frantz, Robert, Torres, Fernando, Quinn, Deborah A., Comhair, Suzy, Erzurum, Serpil, Asosingh, Kewal

“…Pulmonary arterial hypertension (PAH) is a progressive disease characterized by severe remodeling of the pulmonary artery resulting in increased pulmonary…”
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Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury by Choi, Won-Il, Quinn, Deborah A, Park, Kwon Moo, Moufarrej, Ramzi K, Jafari, Behrouz, Syrkina, Olga, Bonventre, Joseph V, Hales, Charles A

“…Positive pressure mechanical ventilation has significant systemic effects, but the systemic effects associated with ventilator-induced lung injury (VILI) are…”
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Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study by HOEPER, Marius M, BARST, Robyn J, MORRELL, Nicholas W, PEACOCK, Andrew J, SATOH, Toru, SIMONNEAU, Gerald, TAPSON, Victor F, TORRES, Fernando, LAWRENCE, David, QUINN, Deborah A, GHOFRANI, Hossein-Ardeschir, BOURGE, Robert C, FELDMAN, Jeremy, FROST, Adaani E, GALIE, Nazzareno, ANGEL GOMEZ-SANCHEZ, Miguel, GRIMMINGER, Friedrich, GRÜNIG, Ekkehard, HASSOUN, Paul M

“…By its inhibitory effect on platelet-derived growth factor signaling, imatinib could be efficacious in treating patients with pulmonary arterial hypertension…”
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JNK activation is responsible for mucus overproduction in smoke inhalation injury by Choi, Won-Ii, Syrkina, Olga, Kwon, Kun Young, Quinn, Deborah A, Hales, Charles A

“…Increased mucus secretion is one of the important characteristics of the response to smoke inhalation injuries. We hypothesized that gel-forming mucins may…”
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Low Molecular Weight Hyaluronan from Stretched Lung Enhances Interleukin-8 Expression by Mascarenhas, Marcella M, Day, Regina M, Ochoa, Cristiaan D, Choi, Won-Il, Yu, Lunyin, Ouyang, Bin, Garg, Hari G, Hales, Charles A, Quinn, Deborah A

“…Mechanical ventilation has been shown to cause ventilator-induced lung injury (VILI), probably by overdistending or stretching the lung. Hyaluronan (HA), a…”
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Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension by Ochoa, Cristhiaan D, Yu, Lunyin, Al-Ansari, Essam, Hales, Charles A, Quinn, Deborah A

“…Chronic hypoxia induces pulmonary hypertension in mice. Smooth muscle cell hyperplasia and medial thickening characterize the vasculature of these animals…”
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Cyclic Stretch Affects Pulmonary Endothelial Cell Control of Pulmonary Smooth Muscle Cell Growth by Ochoa, Cristhiaan D, Baker, Haven, Hasak, Stephen, Matyal, Robina, Salam, Aleya, Hales, Charles A, Hancock, William, Quinn, Deborah A

“…Endothelial cells are subjected to mechanical forces in the form of cyclic stretch resulting from blood pulsatility. Pulmonary artery endothelial cells (PAECs)…”
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Low-molecular-weight heparin inhibits hypoxic pulmonary hypertension and vascular remodeling in guinea pigs by Al-Ansari, Essam, Du, Hong-kai, Yu, Lunyin, Ochoa, Cristhiaan D, Garg, Hari G, Quinn, Deborah A, Hales, Charles A

“…We have shown previously that antiproliferative unfractionated heparins block hypoxia-induced pulmonary arterial hypertension (PAH) and vascular remodeling,…”
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Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells by Jafari, Behrouz, Ouyang, Bin, Li, Li-Fu, Hales, Charles A., Quinn, Deborah A.

“…Objective:  Ventilator‐induced lung injury (VILI) is characterized by release of inflammatory cytokines, but the mechanisms are not well understood. We…”
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