Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: Potential implications for SARS‐CoV‐2 infection

Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: Potential implications for SARS‐CoV‐2 infection

Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin‐converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome coronavirus 2, in these cells. We report ACE2 expression...

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Bibliographic Details
Published in:Pulmonary circulation Vol. 12; no. 2; pp. e12068 - n/a
Main Authors: Toe, Quezia K., Issitt, Theo, Mahomed, Abdul, Almaghlougth, Fatma, Bahree, Ishan, Sturge, Charles, Hu, Xueqi, Panselinas, Ioannis, Burke‐Gaffney, Anne, Wort, Stephen, Jc, Quinlan, Gregory John
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-04-2022
John Wiley and Sons Inc
Wiley
Subjects:
Anemia
Chronic illnesses
COVID-19
Endothelium
hepcidin/ferroportin axis
Infections
interleukin‐6
Iron
Metabolism
Mortality
Protein expression
Proteins
Pulmonary arteries
pulmonary artery endothelial cells
Research Letter
Severe acute respiratory syndrome coronavirus 2
Thrombosis
Veins & arteries
hepcidin/ferroportin axis
COVID‐19
interleukin‐6
pulmonary artery endothelial cells
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Summary:Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin‐converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome coronavirus 2, in these cells. We report ACE2 expression and positive regulation by both interleuki‐6, hepcidin, and ferroportin knock‐down in pulmonary artery endothelial cells with potential implications for viral infection.
Bibliography:ObjectType-Article-1
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ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1002/pul2.12068