Search Results - "Quinlan, Elizabeth M."

Critical periods in amblyopia by Hensch, Takao K, Quinlan, Elizabeth M

“…The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation is the canonical model of synaptic plasticity confined to a postnatal…”
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Obligatory Role for the Immediate Early Gene NARP in Critical Period Plasticity by Gu, Yu, Huang, Shiyong, Chang, Michael C., Worley, Paul, Kirkwood, Alfredo, Quinlan, Elizabeth M.

“…The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding…”
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Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes by Nakazawa, Kazu, Belforte, Juan E, Zsiros, Veronika, Sklar, Elyse R, Jiang, Zhihong, Yu, Gu, Li, Yuqing, Quinlan, Elizabeth M

“…Nakazawa and colleagues describe a mouse strain in which the NR1 subunit of the NMDA receptor is selectively eliminated in cortical and hippocampal…”
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Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 by Murase, Sachiko, Lantz, Crystal L, Quinlan, Elizabeth M

“…The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have…”
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Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period by Gu, Yu, Tran, Trinh, Murase, Sachiko, Borrell, Andrew, Kirkwood, Alfredo, Quinlan, Elizabeth M

“…Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical…”
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Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure by Montey, Karen L., Quinlan, Elizabeth M.

“…Chronic monocular deprivation induces severe amblyopia that is resistant to spontaneous reversal. However, dark exposure initiated in adulthood reactivates…”
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Two distinct mechanisms for experience-dependent homeostasis by Bridi, Michelle C. D., de Pasquale, Roberto, Lantz, Crystal L., Gu, Yu, Borrell, Andrew, Choi, Se-Young, He, Kaiwen, Tran, Trinh, Hong, Su Z., Dykman, Andrew, Lee, Hey-Kyoung, Quinlan, Elizabeth M., Kirkwood, Alfredo

“…Models of firing rate homeostasis such as synaptic scaling and the sliding synaptic plasticity modification threshold predict that decreasing neuronal activity…”
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Visual Deprivation Reactivates Rapid Ocular Dominance Plasticity in Adult Visual Cortex by He, Hai-Yan, Hodos, William, Quinlan, Elizabeth M

“…Brief monocular deprivation (< or =3 d) induces a rapid shift in the ocular dominance of binocular neurons in the juvenile rodent visual cortex but is…”
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Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex by Murase, Sachiko, Winkowski, Dan, Liu, Ji, Kanold, Patrick O, Quinlan, Elizabeth M

“…Dark exposure (DE) followed by light reintroduction (LRx) reactivates robust synaptic plasticity in adult mouse primary visual cortex (V1), which allows…”
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Chronic Monocular Deprivation Reveals MMP9-Dependent and -Independent Aspects of Murine Visual System Plasticity by Murase, Sachiko, Robertson, Sarah E, Lantz, Crystal L, Liu, Ji, Winkowski, Daniel E, Quinlan, Elizabeth M

“…The deletion of matrix metalloproteinase MMP9 is combined here with chronic monocular deprivation (cMD) to identify the contributions of this proteinase to…”
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Naturalistic Spike Trains Drive State-Dependent Homeostatic Plasticity in Superficial Layers of Visual Cortex by Chokshi, Varun, Grier, Bryce D, Dykman, Andrew, Lantz, Crystal L, Niebur, Ernst, Quinlan, Elizabeth M, Lee, Hey-Kyoung

“…The history of neural activity determines the synaptic plasticity mechanisms employed in the brain. Previous studies report a rapid reduction in the strength…”
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A Molecular Mechanism for Stabilization of Learning-Induced Synaptic Modifications by Quinlan, Elizabeth M, Lebel, David, Brosh, Inbar, Barkai, Edi

“…Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that…”
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Regulation of Synaptic Strength by Protein Phosphatase 1 by Morishita, Wade, Connor, John H, Xia, Houhui, Quinlan, Elizabeth M, Shenolikar, Shirish, Malenka, Robert C

“…We investigated the role of postsynaptic protein phosphatase 1 (PP1) in regulating synaptic strength by loading CA1 pyramidal cells either with peptides that…”
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A Biophysical Model of Bidirectional Synaptic Plasticity: Dependence on AMPA and NMDA Receptors by Castellani, Gastone C., Quinlan, Elizabeth M., Cooper, Leon N, Shouval, Harel Z.

“…In many regions of the brain, including the mammalian cortex, the magnitude and direction of activity-dependent changes in synaptic strength depend on the…”
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Optimization of Visual Training for Full Recovery from Severe Amblyopia in Adults by Eaton, Nicolette C, Sheehan, Hanna Marie, Quinlan, Elizabeth M

“…The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery…”
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Learning in the Absence of Experience-Dependent Regulation of NMDAR Composition by Lebel, David, Sidhu, Nishchal, Barkai, Edi, Quinlan, Elizabeth M

“…Olfactory discrimination (OD) learning consists of two phases: an initial N-methyl-d-aspartate (NMDA) receptor--sensitive rule-learning phase, followed by an…”
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Experience-dependent recovery of vision following chronic deprivation amblyopia by Quinlan, Elizabeth M, Dennis, Katie, Ray, Baisali, He, Hai-Yan

“…The shift in ocular dominance induced by brief monocular deprivation is greatest during a postnatal critical period and is thought to decline irreversibly…”
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A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure by Huang, Shiyong, Gu, Yu, Quinlan, Elizabeth M, Kirkwood, Alfredo

“…Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity in the visual cortex. Here, we show that a critical component of the…”
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All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity by Severin, Daniel, Hong, Su Z., Roh, Seung-Eon, Huang, Shiyong, Zhou, Jiechao, Bridi, Michelle C. D., Hong, Ingie, Murase, Sachiko, Robertson, Sarah, Haberman, Rebecca P., Huganir, Richard L., Gallagher, Michela, Quinlan, Elizabeth M., Worley, Paul, Kirkwood, Alfredo

“…Disinhibition is an obligatory initial step in the remodeling of cortical circuits by sensory experience. Our investigation on disinhibitory mechanisms in the…”
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Acute forced exercise increases Bdnf IV mRNA and reduces exploratory behavior in C57BL/6J mice by Venezia, Andrew C., Hyer, Molly M., Glasper, Erica R., Roth, Stephen M., Quinlan, Elizabeth M.

“…Acute exercise has been shown to improve memory in humans. Potential mechanisms include increased Bdnf expression, noradrenergic activity and modification of…”
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