Search Results - "Quigg, Richard"

Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial by Yacoub, Rabi, Nugent, Melinda, Cai, Weijin, Nadkarni, Girish N, Chaves, Lee D, Abyad, Sham, Honan, Amanda M, Thomas, Shruthi A, Zheng, Wei, Valiyaparambil, Sujith A, Bryniarski, Mark A, Sun, Yijun, Buck, Michael, Genco, Robert J, Quigg, Richard J, He, John C, Uribarri, Jaime

“…The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of…”
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Complement: Functions, location and implications by Kareem, Samer, Jacob, Alexander, Mathew, John, Quigg, Richard J., Alexander, Jessy J.

“…The complement system, an arm of the innate immune system plays a critical role in both health and disease. The complement system is highly complex with dual…”
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MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy by Wang, Qiang, Wang, Youli, Minto, Andrew W, Wang, Jinhua, Shi, Qun, Li, Xinmin, Quigg, Richard J

“…Intrinsic glomerular cells in a diabetic milieu have transcriptional activation of genes that influence the development of diabetic nephropathy. The cellular…”
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Local complement factor H protects kidney endothelial cell structure and function by Mahajan, Supriya, Jacob, Alexander, Kelkar, Anju, Chang, Anthony, Mcskimming, Daniel, Neelamegham, Sriram, Quigg, Richard J, Alexander, Jessy J

“…Factor H (FH) is a critical regulator of the alternative complement pathway and its deficiency or mutation underlie kidney diseases such as dense deposit…”
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miR-17-92 Cluster Accelerates Adipocyte Differentiation by Negatively Regulating Tumor-Suppressor Rb2/p130 by Wang, Qiang, Li, Yan Chun, Wang, Jinhua, Kong, Juan, Qi, Yuchen, Quigg, Richard J., Li, Xinmin

“…Adipogenesis involves cell proliferation and differentiation, both of which have been shown to be regulated by micro (mi)RNA. During mouse preadipocyte 3T3L1…”
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Complement Factor H Deficiency Accelerates Development of Lupus Nephritis by LIHUA BAO, HAAS, Mark, QUIGG, Richard J

“…Complement factor H (CfH) is a key regulator of the alternative pathway, and its presence on mouse platelets and podocytes allows the processing of immune…”
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In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis by Chang, Anthony, Henderson, Scott G, Brandt, Daniel, Liu, Ni, Guttikonda, Riteesha, Hsieh, Christine, Kaverina, Natasha, Utset, Tammy O, Meehan, Shane M, Quigg, Richard J, Meffre, Eric, Clark, Marcus R

“…The most prevalent severe manifestation of systemic lupus erythematosus is nephritis, which is characterized by immune complex deposition, inflammation, and…”
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The ICD-9 to ICD-10 transition has not improved identification of rapidly progressing stage 3 and stage 4 chronic kidney disease patients: a diagnostic test study by Jalal, Kabir, Charest, Andre, Wu, Xiaoyan, Quigg, Richard J, Chang, Shirley

“…The International Classification of Diseases (ICD) coding system is the industry standard tool for billing, disease classification, and epidemiology purposes…”
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Lupus: The microbiome angle by Yacoub, Rabi, Jacob, Alexander, Wlaschin, Josette, McGregor, Matthew, Quigg, Richard J., Alexander, Jessy J.

“…Microbiota consists of more than 1014 microorganisms that inhabit different areas of the body including the gastrointestinal tract, mainly the mouth and gut…”
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TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1 by Alexander, Jessy J., Jacob, Alexander, Cunningham, Patrick, Hensley, Lauren, Quigg, Richard J.

“…In this study, we demonstrate that mice deficient in TNFR1 (TNFR1 −/−) were resistant to LPS-induced encephalopathy. Systemic administration of…”
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Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG by SARAV, Menaka, YING WANG, HACK, Bradley K, CHANG, Anthony, JENSEN, Mark, LIHUA BAO, QUIGG, Richard J

“…The widely distributed neonatal Fc receptor (FcRn) contributes to maintaining serum levels of albumin and IgG in adults. In the kidney, FcRn is expressed on…”
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Macrophage Depletion Reduces Disease Pathology in Factor H-Dependent Immune Complex-Mediated Glomerulonephritis by Jacob, Alexander, Phelps, Michael, Fraher, Shane, Lopez, Marcos, Chang, Anthony, Quigg, Richard J., Alexander, Jessy J.

“…Complement factor H (FH) is a key regulator of the alternative pathway of complement, in man and mouse. Earlier, our studies revealed that the absence of FH…”
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C5a alters blood-brain barrier integrity in experimental lupus by Jacob, Alexander, Hack, Bradley, Chiang, Eddie, Garcia, Joe G.N, Quigg, Richard J, Alexander, Jessy J

“…The blood-brain barrier (BBB) is a crucial anatomic location in the brain. Its dysfunction complicates many neurodegenerative diseases, from acute conditions,…”
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Complement in Lupus Nephritis: New Perspectives by Bao, Lihua, Cunningham, Patrick N., Quigg, Richard J.

“…Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder caused by loss of tolerance to self-antigens, the production of autoantibodies and…”
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Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury by Bao, Lihua, Wang, Ying, Haas, Mark, Quigg, Richard J.

“…To prevent injury to host tissues, complement activation is regulated by a number of plasma and membrane-associated proteins, most of which limit C3 and C5…”
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C5a/CD88 signaling alters blood–brain barrier integrity in lupus through nuclear factor‐κB by Jacob, Alexander, Hack, Bradley, Chen, Peili, Quigg, Richard J., Alexander, Jessy J.

“…J. Neurochem. (2011) 119, 1041–1051. Inflammation is a key factor in a number of neurodegenerative diseases including systemic lupus erythematosus. The…”
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C5a alters blood–brain barrier integrity in a human in vitro model of systemic lupus erythematosus by Mahajan, Supriya D., Parikh, Neil U., Woodruff, Trent M., Jarvis, James N., Lopez, Molly, Hennon, Teresa, Cunningham, Patrick, Quigg, Richard J., Schwartz, Stanley A., Alexander, Jessy J.

“…Summary The blood–brain barrier (BBB) plays a crucial role in brain homeostasis, thereby maintaining the brain environment precise for optimal neuronal…”
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CD11b is protective in complement-mediated immune complex glomerulonephritis by Alexander, Jessy J, Chaves, Lee D, Chang, Anthony, Jacob, Alexander, Ritchie, Maria, Quigg, Richard J

“…In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent,…”
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Complement activation in the tubulointerstitium: AKI, CKD, and in between by Brar, Jyoti E, Quigg, Richard J

“…Complement activation is actively regulated to prevent injudicious activation, such as on peritubular endothelia and basolateral aspects of tubules. Miao et…”
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Complement Regulation in Renal Disease Models by Naik, Abhijit, MD, Sharma, Shweta, MD, Quigg, Richard J., MD

“…Summary Activation of the complement system is tightly regulated by plasma and cell-associated complement regulatory proteins (CRPs), such as factor H (fH),…”
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