Search Results - "Quick, Kevin L"

Ketamine-Induced Loss of Phenotype of Fast-Spiking Interneurons Is Mediated by NADPH-Oxidase by Behrens, M. Margarita, Ali, Sameh S, Dao, Diep N, Lucero, Jacinta, Shekhtman, Grigoriy, Quick, Kevin L, Dugan, Laura L

“…Abuse of the dissociative anesthetic ketamine can lead to a syndrome indistinguishable from schizophrenia. In animals, repetitive exposure to this…”
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IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase by Dugan, Laura L, Ali, Sameh S, Shekhtman, Grigoriy, Roberts, Amanda J, Lucero, Jacinta, Quick, Kevin L, Behrens, M Margarita

“…Multiple studies have shown that plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) are elevated in patients with important and prevalent…”
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A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules by Lee, Ha Won, Khan, Samia Q, Faridi, Mohd Hafeez, Wei, Changli, Tardi, Nicholas J, Altintas, Mehmet M, Elshabrawy, Hatem A, Mangos, Steve, Quick, Kevin L, Sever, Sanja, Reiser, Jochen, Gupta, Vineet

“…Podocyte injury and loss mark an early step in the pathogenesis of various glomerular diseases, making these cells excellent targets for therapeutics. However,…”
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A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice by Quick, Kevin L, Ali, Sameh S, Arch, Robert, Xiong, Chengjie, Wozniak, David, Dugan, Laura L

“…Abstract In lower organisms, such as Caenorhabditis elegans and Drosophila , many genes identified as key regulators of aging are involved in either…”
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Gender differences in free radical homeostasis during aging: shorter‐lived female C57BL6 mice have increased oxidative stress by Ali, Sameh S., Xiong, Chengjie, Lucero, Jacinta, Behrens, M. Margarita, Dugan, Laura L., Quick, Kevin L.

“…Summary Gender is a profound determinant of aging and lifespan, but little is known about gender differences in free radical homeostasis. Free radicals are…”
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Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia by Ruden, Jacob B, Quick, Kevin L, Gonzales, Ernesto R, Shah, Aarti R, Park, T S, Kennedy, Nan, Dugan, Laura L, Gidday, Jeffrey M

“…Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during…”
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High-throughput imaging: Focusing in on drug discovery in 3D by Li, Linfeng, Zhou, Qiong, Voss, Ty C., Quick, Kevin L., LaBarbera, Daniel V.

“…•High-throughput image based drug discovery using 3D organoid and MCTS.•An overview of state-of-the-art 3D high-throughput imaging systems and…”
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Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia by Quick, Kevin L., Dugan, Laura L.

“…Ataxia‐telangiectasia (A‐T) is an autosomal recessive disorder caused by mutations in the ATM gene. A‐T children demonstrate sensitivity to ionizing radiation,…”
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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo by Najm, Fadi J., Madhavan, Mayur, Zaremba, Anita, Shick, Elizabeth, Karl, Robert T., Factor, Daniel C., Miller, Tyler E., Nevin, Zachary S., Kantor, Christopher, Sargent, Alex, Quick, Kevin L., Schlatzer, Daniela M., Tang, Hong, Papoian, Ruben, Brimacombe, Kyle R., Shen, Min, Boxer, Matthew B., Jadhav, Ajit, Robinson, Andrew P., Podojil, Joseph R., Miller, Stephen D., Miller, Robert H., Tesar, Paul J.

“…Two drugs, miconazole and clobetasol, have functions that modulate differentiation of oligodendrocyte progenitor cells directly, enhance remyelination, and…”
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BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production by Kim‐Han, Jeong Sook, Reichert, Susan A., Quick, Kevin L., Dugan, Laura L.

“…Outside the nervous system, members of the mitochondrial uncoupling protein (UCP) family have been proposed to contribute to control of body temperature and…”
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Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates by Dugan, Laura L., Tian, LinLin, Quick, Kevin L., Hardt, Josh I., Karimi, Morvarid, Brown, Chris, Loftin, Susan, Flores, Hugh, Moerlein, Stephen M., Polich, John, Tabbal, Samer D., Mink, Jonathan W., Perlmutter, Joel S.

“…Objective We evaluated the efficacy of the potent antioxidant C3 to salvage nigrostriatal neuronal function after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine…”
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A biologically effective fullerene (C 60) derivative with superoxide dismutase mimetic properties by Ali, Sameh S., Hardt, Joshua I., Quick, Kevin L., Sook Kim-Han, Jeong, Erlanger, Bernard F., Huang, Ting-ting, Epstein, Charles J., Dugan, Laura L.

“…Superoxide, a potentially toxic by-product of cellular metabolism, may contribute to tissue injury in many types of human disease. Here we show that a…”
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Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid [C3] in Mice and Primates by Hardt, Joshua I., Perlmutter, Joel S., Smith, Christopher J., Quick, Kevin L., Wei, Ling, Chakraborty, Subhasish K., Dugan, Laura L.

“…Background and Objectives Fullerene-based compounds are a novel class of molecules being developed for a variety of biomedical applications, with nearly 1000…”
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Reactive oxygen species and aging: evolving questions by Dugan, Laura L, Quick, Kevin L

“…Over the past 50 years, reactive oxygen species (ROS) have been investigated as putative mediators of the process of aging. As specific genes and pathways that…”
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Pharmacokinetics and toxicology of the neuroprotective e,e,e-methanofullerene(63)-carboxylic acid in mice and primates by Hardt, Joshua I., Perlmutter, Joel S., Smith, Christopher J., Quick, Kevin L., Wei, Ling, Chakraborty, Subhasish K., Dugan, Laura L.

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Pharmacokinetics and Toxicology of the Neuroprotective e,e,e-Methanofullerene(60)-63-tris Malonic Acid C3 in Mice and Primates by Hardt, Joshua I, Perlmutter, Joel S, Smith, Christopher J, Quick, Kevin L, Wei, Ling, Chakraborty, Subhasish K, Dugan, Laura L

“…Fullerene-based compounds are a novel class of molecules being developed for a variety of biomedical applications, with nearly 1000 publications in this area…”
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Carboxyfullerene neuroprotection post injury in parkinsonian nonhuman primates by Dugan, Laura L., Tian, LinLin, Quick, Kevin L., Hardt, Josh I., Karimi, Morvarid, Brown, Chris, Loftin, Susan, Flores, Hugh, Moerlein, Stephen M., Polich, John, Tabbal, Samer D., Mink, Jonathan W., Perlmutter, Joel S.

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Rapid microplate assay for superoxide scavenging efficiency by Quick, Kevin L., Hardt, Joshua I., Dugan, Laura L.

“…Here we report a method to determine superoxide scavenging efficiency, using kinetic analysis of cytochrome c reduction and an automated UV/vis microtiter…”
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