Search Results - "Quick, Ann P"

SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity by Quick, Ann P, Wang, Qiongling, Philippen, Leonne E, Barreto-Torres, Giselle, Chiang, David Y, Beavers, David, Wang, Guoliang, Khalid, Maha, Reynolds, Julia O, Campbell, Hannah M, Showell, Jordan, McCauley, Mark D, Scholten, Arjen, Wehrens, Xander H.T

“…RATIONALE:Junctional membrane complexes (JMCs) in myocytes are critical microdomains, in which excitation–contraction coupling occurs. Structural and…”
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Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy by Wang, Qiongling, Quick, Ann P, Cao, Shuyi, Reynolds, Julia, Chiang, David Y, Beavers, David, Li, Na, Wang, Guoliang, Rodney, George G, Anderson, Mark E, Wehrens, Xander H.T

“…BACKGROUND:Duchenne muscular dystrophy patients are prone to ventricular arrhythmias, which may be caused by abnormal calcium (Ca) homeostasis and elevated…”
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Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation by Chiang, David Y, Li, Na, Wang, Qiongling, Alsina, Katherina M, Quick, Ann P, Reynolds, Julia O, Wang, Guoliang, Skapura, Darlene, Voigt, Niels, Dobrev, Dobromir, Wehrens, Xander H T

“…Altered Ca(2+) handling in atrial fibrillation (AF) has been associated with dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in…”
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Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure by Shen, Xin, van den Brink, Jonas, Bergan-Dahl, Anna, Kolstad, Terje R, Norden, Einar S, Hou, Yufeng, Laasmaa, Martin, Aguilar-Sanchez, Yuriana, Quick, Ann P, Espe, Emil KS, Sjaastad, Ivar, Wehrens, Xander HT, Edwards, Andrew G, Soeller, Christian, Louch, William E

“…Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca 2+…”
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SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice by Hinton, Jr, Antentor Othrell, Yang, Yongjie, Quick, Ann P, Xu, Pingwen, Reddy, Chitra L, Yan, Xiaofeng, Reynolds, Corey L, Tong, Qingchun, Zhu, Liangru, Xu, Jianming, Wehrens, Xander H T, Xu, Yong, Reddy, Anilkumar K

“…Framingham Heart Study suggests that dysfunction of steroid receptor coactivator-1 may be involved in the development of hypertension. However, there is no…”
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Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling by Quick, Ann P., BA, Landstrom, Andrew P., MD, PhD, Wehrens, Xander H.T., MD, PhD, FHRS

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Clinical Utility of the 31-Gene Expression Profile Test on the Management of Cutaneous Melanoma by Nurse Practitioners and Physician Assistants by Block, Renata, Patterson, Deborah, Siegel, Jennifer J, Martin, Brian, Quick, Ann P, Hunt, Jillian

“…The 31-gene expression profile (31-GEP) can predict the risk of recurrence and metastasis in cutaneous melanoma (CM). We assessed the viewpoints and use of…”
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Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction by Quick, Ann P., BA, Landstrom, Andrew P., MD, PhD, Wang, Qiongling, PhD, Beavers, David L., MD, PhD, Reynolds, Julia O., BS, Barreto-Torres, Giselle, PhD, Tran, Viet, MD, Showell, Jordan, BS, Philippen, Leonne E., MSc, Morris, Shaine A., MD, MPH, Skapura, Darlene, BS, Bos, J. Martijn, MD, Pedersen, Steen E., PhD, Pautler, Robia G., PhD, Ackerman, Michael J., MD, PhD, Wehrens, Xander H.T., MD, PhD

“…Visual Abstract…”
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SPEG: a key regulator of cardiac calcium homeostasis by Campbell, Hannah, Aguilar-Sanchez, Yuriana, Quick, Ann P, Dobrev, Dobromir, Wehrens, Xander H T

“…Abstract Proper cardiac Ca2+ homeostasis is essential for normal excitation–contraction coupling. Perturbations in cardiac Ca2+ handling through altered kinase…”
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STAT3: a link between CaMKII-βIV-spectrin and maladaptive remodeling? by Hulsurkar, Mohit, Quick, Ann P, Wehrens, Xander Ht

“…βIV-Spectrin, along with ankyrin and Ca2+/calmodulin-dependent kinase II (CaMKII), has been shown to form local signaling domains at the intercalated disc,…”
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Optimizing treatment approaches for patients with cutaneous melanoma by integrating clinical and pathologic features with the 31-gene expression profile test by Jarell, Abel, Gastman, Brian R., Dillon, Larry D., Hsueh, Eddy C., Podlipnik, Sebastian, Covington, Kyle R., Cook, Robert W., Bailey, Christine N., Quick, Ann P., Martin, Brian J., Kurley, Sarah J., Goldberg, Matthew S., Puig, Susana

“…Many patients with low-stage cutaneous melanoma will experience tumor recurrence, metastasis, or death, and many higher staged patients will not. To develop an…”
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Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation by Campbell, Hannah M., Quick, Ann P., Abu-Taha, Issam, Chiang, David Y., Kramm, Carlos F., Word, Tarah A., Brandenburg, Sören, Hulsurkar, Mohit, Alsina, Katherina M., Liu, Hui-Bin, Martin, Brian, Uhlenkamp, Dennis, Moore, Oliver M., Lahiri, Satadru K., Corradini, Eleonora, Kamler, Markus, Heck, Albert J.R., Lehnart, Stephan E., Dobrev, Dobromir, Wehrens, Xander H.T.

“…BACKGROUND:Enhanced diastolic calcium (Ca) release through ryanodine receptor type-2 (RyR2) has been implicated in atrial fibrillation (AF) promotion…”
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Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling by Lahiri, Satadru K., Quick, Ann P., Samson-Couterie, Benoit, Hulsurkar, Mohit, Elzenaar, Ies, van Oort, Ralph J., Wehrens, Xander H. T.

“…Heart failure (HF) is a leading cause of morbidity and mortality worldwide. Patients with HF exhibit a loss of junctophilin-2 (JPH2), a structural protein…”
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Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation by Alsina, Katherina M, Hulsurkar, Mohit, Brandenburg, Sören, Kownatzki-Danger, Daniel, Lenz, Christof, Urlaub, Henning, Abu-Taha, Issam, Kamler, Markus, Chiang, David Y, Lahiri, Satadru K, Reynolds, Julia O, Quick, Ann P, Scott, Larry, Word, Tarah A, Gelves, Maria D, Heck, Albert J.R, Li, Na, Dobrev, Dobromir, Lehnart, Stephan E, Wehrens, Xander H.T

“…BACKGROUND:Abnormal calcium (Ca) release from the sarcoplasmic reticulum (SR) contributes to the pathogenesis of atrial fibrillation (AF). Increased…”
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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release by Reynolds, Julia O., Quick, Ann P., Wang, Qiongling, Beavers, David L., Philippen, Leonne E., Showell, Jordan, Barreto-Torres, Giselle, Thuerauf, Donna J., Doroudgar, Shirin, Glembotski, Christopher C., Wehrens, Xander H.T.

“…Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine…”
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Expanded evidence that the 31-gene expression profile test provides clinical utility for melanoma management in a multicenter study by Dillon, Larry D., McPhee, Michael, Davidson, Robert S., Quick, Ann P., Martin, Brian, Covington, Kyle R., Zolochevska, Olga, Cook, Robert W., Vetto, John T., Jarell, Abel D., Fleming, Martin D.

“…National Comprehensive Cancer Network (NCCN) guidelines for cutaneous melanoma (CM) recommend physicians consider increased surveillance for patients who…”
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Efficacy of RyR2 inhibitor EL20 in induced pluripotent stem cell-derived cardiomyocytes from a patient with catecholaminergic polymorphic ventricular tachycardia by Word, Tarah A, Quick, Ann P, Miyake, Christina Y, Shak, Mayra K, Pan, Xiaolu, Kim, Jean J, Allen, Hugh D, Sibrian-Vazquez, Martha, Strongin, Robert M, Landstrom, Andrew P, Wehrens, Xander H T

“…Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac arrhythmia syndrome that often leads to sudden cardiac death. The most…”
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Development and validation of a nomogram incorporating gene expression profiling and clinical factors for accurate prediction of metastasis in patients with cutaneous melanoma following Mohs micrographic surgery by Thorpe, Ryan B., Covington, Kyle R., Caruso, Hillary G., Quick, Ann P., Zolochevska, Olga, Bricca, Gregory M., Campoli, Michael, DeBloom, James R., Fazio, Michael J., Greenhaw, Bradley N., Kirkland, E. Brent, Machan, Mac L., Brodland, David G., Zitelli, John A.

“…There is a need to improve prognostic accuracy for patients with cutaneous melanoma. A 31-gene expression profile (31-GEP) test uses the molecular biology of…”
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The 31-gene expression profile stratifies recurrence and metastasis risk in patients with cutaneous melanoma by Jarell, Abel, Skenderis, Basil, Dillon, Larry D, Dillon, Kelsey, Martin, Brian, Quick, Ann P, Siegel, Jennifer J, Rackley, Briana B, Cook, Robert W

“…Sentinel node biopsy is a prognostic indicator of melanoma recurrence. We hypothesized that adding the primary melanoma molecular signature from the 31-gene…”
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Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies by Lahiri, Satadru K, Jin, Feng, Zhou, Yue, Quick, Ann P, Kramm, Carlos F, Wang, Meng C, Wehrens, Xander Ht

“…Myocardial lipid metabolism is critical to normal heart function, whereas altered lipid regulation has been linked to cardiac diseases including…”
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