Three cases of intraocular mesectodermal leiomyoma expressing progesterone and androgen receptors

Background/Aims A prospective study identified three patients between 2004 and 2010 with mesectodermal leiomyoma. The study was conducted to analyse the presence or absence of sex steroid hormone receptors in mesectodermal leiomyomas. Methods The clinical features were collated. All three patients h...

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Bibliographic Details
Published in:	Eye (London) Vol. 27; no. 5; pp. 669 - 672
Main Authors:	Quhill, H, Rennie, I G, Rundle, P A, Mudhar, H S
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-05-2013 Nature Publishing Group
Subjects:	631/443/163/812 631/45/612/388 692/699/67/1484 692/699/67/1517 Aged Case Series Female Humans Immunohistochemistry Iris Neoplasms - metabolism Laboratory Medicine Leiomyoma - metabolism Male Medicine Medicine & Public Health Middle Aged Ophthalmology Pharmaceutical Sciences/Technology Progesterone - metabolism Prospective Studies Receptors, Androgen - metabolism Surgery Surgical Oncology Uveal Neoplasms - metabolism mexectodermal androgen receptor progesterone receptor leiomyoma
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Summary:	Background/Aims A prospective study identified three patients between 2004 and 2010 with mesectodermal leiomyoma. The study was conducted to analyse the presence or absence of sex steroid hormone receptors in mesectodermal leiomyomas. Methods The clinical features were collated. All three patients had operative procedures to either remove or sample the mesectodermal leiomyomas. The tissue was fixed in formalin and exposed to conventional histological processing. Immunohistochemistry using antibodies to androgen (AR), oestrogen (ER), and progesterone (PR) receptors was performed, followed by stain scoring to assess for expression status. Results All three cases were confirmed by histology to be examples of mesectodermal leiomyomas. All three expressed sex steroid hormone receptors. One case expressed both PR and AR, one case PR only and another case AR only. None of the cases expressed ER receptors. Conclusion All three cases displayed some sex steroid hormone receptor expression. This is supportive evidence that sex steroid hormones may have a role in the pathogenesis of this tumour and suggest that it may be amenable to hormonal manipulation therapy, in a manner similar to conventional uterine leiomyomas.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0950-222X 1476-5454
DOI:	10.1038/eye.2013.37