Search Results - "Quezada, Elías"

Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders by Quezada, Elías, Rodríguez-Enríquez, Fernanda, Laguna, Reyes, Cutrín, Elena, Otero, Francisco, Uriarte, Eugenio, Viña, Dolores

“…Neurodegenerative diseases have a complex nature which highlights the need for multitarget ligands to address the complementary pathways involved in these…”
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Phytochemical Analysis and Antiproliferative Activity of Ulex gallii Planch. (Fabaceae), a Medicinal Plant from Galicia (Spain) by Bada, Lucía, Pereira, Renato B, Pereira, David M, Lores, Marta, Celeiro, María, Quezada, Elías, Uriarte, Eugenio, Gil-Longo, José, Viña, Dolores

“…The genus comprises thirteen accepted species of perennial shrubs in the family Fabaceae. In Galicia (Spain) many of these are considered spontaneous…”
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Quantitative Structure−Activity Relationship and Complex Network Approach to Monoamine Oxidase A and B Inhibitors by Santana, Lourdes, González-Díaz, Humberto, Quezada, Elías, Uriarte, Eugenio, Yáñez, Matilde, Viña, Dolores, Orallo, Francisco

“…The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the…”
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Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin–resveratrol hybrids by Vilar, Santiago, Quezada, Elías, Santana, Lourdes, Uriarte, Eugenio, Yánez, Matilde, Fraiz, Nuria, Alcaide, Carlos, Cano, Ernesto, Orallo, Francisco

“…We have synthesized the coumarin–resveratrol hybrid 4 and its dimethoxy derivative 3 by a very direct synthetic route involving a Pechmann procedure. Compound…”
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Potent, selective and reversible hMAO-B inhibition by benzalphthalides: Synthesis, enzymatic and cellular evaluations and virtual docking and predictive studies by Olmo, Esther del, Barboza, Bianca, Delgado-Esteban, Maria, Escala, Nerea, Jiménez-Blasco, Daniel, Lopez-Pérez, José L., Cillero de la Fuente, Laura, Quezada, Elías, Munín, Javier, Viña, Dolores, Bolaños, Juan P., Feliciano, Arturo San

“…[Display omitted] •11 BPHs inhibited hMAO-B selectively with a Selectivity Indexes (SI) ≥ 100.•1 BPH inhibited hMAO-B selectively at the sub-nanomolar level.•2…”
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Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-halo-3-phenylcoumarins by Quezada, Elías, Delogu, Giovanna, Picciau, Carmen, Santana, Lourdes, Podda, Gianni, Borges, Fernanda, García-Morales, Verónica, Viña, Dolores, Orallo, Francisco

“…A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by…”
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Discovery of new phthalazinones as vasodilator agents and novel pharmacological tools to study calcium channels by Munín, Javier, Quezada, Elías, Viña, Dolores, Uriarte, Eugenio, Delogu, Giovanna Lucía, Gil-Longo, José

“…Hydralazine has led to the synthesis of phthalazinone derivatives which induce vasorelaxation. A new series of 2-(aminoalkyl)-4-benzyl-2H-phthalazin-1-one…”
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Computational Drug Target Screening through Protein Interaction Profiles by Vilar, Santiago, Quezada, Elías, Uriarte, Eugenio, Costanzi, Stefano, Borges, Fernanda, Viña, Dolores, Hripcsak, George

“…The development of computational methods to discover novel drug-target interactions on a large scale is of great interest. We propose a new method for virtual…”
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Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives by Delogu, Giovanna, Picciau, Carmen, Ferino, Giulio, Quezada, Elías, Podda, Gianni, Uriarte, Eugenio, Viña, Dolores

“…Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. Series of 3-indolyl and 3-thiophenylcoumarins were synthesized…”
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A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine by Munín, Javier, Santana, Lourdes, Uriarte, Eugenio, Borges, Fernanda, Quezada, Elías

“…[Display omitted] Two new synthetic strategies have been developed for the synthesis of a new class of cyclophthalazine derivatives…”
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A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors by Matos, Maria Joao, Viña, Dolores, Quezada, Elias, Picciau, Carmen, Delogu, Giovanna, Orallo, Francisco, Santana, Lourdes, Uriarte, Eugenio

“…6-Methyl-3-phenylcoumarins 3–6 were design, synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors. The synthesis of these new…”
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Tyrosinase inhibitor activity of coumarin-resveratrol hybrids by Fais, Antonella, Corda, Marcella, Era, Benedetta, Fadda, M Benedetta, Matos, Maria Joao, Quezada, Elias, Santana, Lourdes, Picciau, Carmen, Podda, Gianni, Delogu, Giovanna

“…In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to…”
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Synthesis, biological evaluation and structure–activity relationships of new phthalazinedione derivatives with vasorelaxant activity by Munín, Javier, Quezada, Elías, Cuiñas, Andrea, Campos-Toimil, Manuel, Uriarte, Eugenio, Santana, Lourdes, Viña, Dolores

“…Five series of 1,4-phthalazinedione derivatives were synthesized in good yields. Vasorelaxant activity of these new derivatives was measured on either intact…”
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Predicting monoamine oxidase inhibitory activity through ligand-based models by Vilar, Santiago, Ferino, Giulio, Quezada, Elias, Santana, Lourdes, Friedman, Carol

“…The evolution of bio- and cheminformatics associated with the development of specialized software and increasing computer power has produced a great interest…”
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Synthesis and vasorelaxant and antiplatelet activities of a new series of (4-Benzylphthalazin-1-ylamino)alcohol derivatives by Munín, Javier, Quezada, Elías, Campos-Toimil, Manuel, Cano, Ernesto, Uriarte, Eugenio, Viña, Dolores

“…A new series of phthalazine derivatives was synthesized by reaction of phthalic anhydride and different substituted phenylacetic acids to yield the…”
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Phytochemical Analysis and Antiproliferative Activity of IUlex gallii/I Planch by Bada, Lucía, Pereira, Renato B, Pereira, David M, Lores, Marta, Celeiro, María, Quezada, Elías, Uriarte, Eugenio, Gil-Longo, José, Viña, Dolores

“…The genus Ulex comprises thirteen accepted species of perennial shrubs in the family Fabaceae. In Galicia (Spain) many of these are considered spontaneous…”
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Redox‐Active Phenolic Compounds Mediate the Cytotoxic and Antioxidant Effects of Carpodesmia tamariscifolia (=Cystoseira tamariscifolia) by Moussa, Hanaa, Quezada, Elías, Viña, Dolores, Riadi, Hassane, Gil‐Longo, José

“…Carpodesmia tamariscifolia is a brown alga rich in (poly)phenols with important cytotoxic and antioxidant effects. However, the relationship between its…”
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A novel tetrahydrobenzoangelicin with dark and photo biological activity by Dalla Via, Lisa, Gia, Ornella, Caffieri, Sergio, García-Argáez, Aída N., Quezada, Elías, Uriarte, Eugenio

“…The synthesis of 8,9,10,11-tetrahydro-5-(3-dimethylaminopropoxy)-4-methylbenzofuro[2,3-h]coumarin (5) is described. The new compound showed the ability to…”
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Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O 2 ‐ vs. N 1 ‐Alkylation by Quezada, Elías, Viña, Dolores, Delogu, Giovanna, Borges, Fernanda, Santana, Lourdes, Uriarte, Eugenio

“…The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild…”
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Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O2- vs. N1-Alkylation by Quezada, Elías, Viña, Dolores, Delogu, Giovanna, Borges, Fernanda, Santana, Lourdes, Uriarte, Eugenio

“…The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild…”
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