Search Results - "Quesniaux, Valérie F. J."

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis by Gasse, Pamela, Riteau, Nicolas, Charron, Sabine, Girre, Sandra, Fick, Lizette, Petrilli, Virginie, Tschopp, Jurg, Lagente, Vincent, Quesniaux, Valerie F. J, Ryffel, Bernhard, Couillin, Isabelle

“…Lung injury leads to pulmonary inflammation and fibrosis through myeloid differentiation primary response gene 88 (MyD88) and the IL-1 receptor 1 (IL-1R1)…”
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IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis by Gasse, Paméla, Riteau, Nicolas, Vacher, Rachel, Michel, Marie-Laure, Fautrel, Alain, di Padova, Franco, Fick, Lizette, Charron, Sabine, Lagente, Vincent, Eberl, Gérard, Le Bert, Marc, Quesniaux, Valérie F J, Huaux, François, Leite-de-Moraes, Maria, Ryffel, Bernhard, Couillin, Isabelle

“…Idiopathic pulmonary fibrosis is a devastating as yet untreatable disease. We demonstrated recently the predominant role of the NLRP3 inflammasome activation…”
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Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice by Nascimento, Mégane, Gombault, Aurélie, Lacerda-Queiroz, Norinne, Panek, Corinne, Savigny, Florence, Sbeity, Malak, Bourinet, Manon, Le Bert, Marc, Riteau, Nicolas, Ryffel, Bernhard, Quesniaux, Valérie F. J., Couillin, Isabelle

“…Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with…”
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IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria by Reverchon, Flora, Mortaud, Stéphane, Sivoyon, Maëliss, Maillet, Isabelle, Laugeray, Anthony, Palomo, Jennifer, Montécot, Céline, Herzine, Améziane, Meme, Sandra, Meme, William, Erard, François, Ryffel, Bernhard, Menuet, Arnaud, Quesniaux, Valérie F J

“…Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral…”
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Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments by Reverchon, Flora, de Concini, Vidian, Larrigaldie, Vanessa, Benmerzoug, Sulayman, Briault, Sylvain, Togbé, Dieudonnée, Ryffel, Bernhard, Quesniaux, Valérie F. J., Menuet, Arnaud

“…Abstract Background Interleukin (IL)-33 is expressed in a healthy brain and plays a pivotal role in several neuropathologies, as protective or contributing to…”
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CD3 + Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site by Rodriguez-Cruz, Adriana, Vesin, Dominique, Ramon-Luing, Lucero, Zuñiga, Joaquin, Quesniaux, Valérie F J, Ryffel, Bernhard, Lascurain, Ricardo, Garcia, Irene, Chávez-Galán, Leslie

“…Macrophages are essential cells of the innate immune response against microbial infections, and they have the ability to adapt under both pro- and…”
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Spinal cord oligodendrocyte‐derived alarmin IL‐33 mediates neuropathic pain by Zarpelon, Ana C., Rodrigues, Francielle C., Lopes, Alexandre H., Souza, Guilherme R., Carvalho, Thacyana T., Pinto, Larissa G., Xu, Damo, Ferreira, Sergio H., Alves‐Filho, Jose C., McInnes, Iain B., Ryffel, Bernhard, Quesniaux, Valérie F. J., Reverchon, Flora, Mortaud, Stéphane, Menuet, Arnaud, Liew, Foo Y., Cunha, Fernando Q., Cunha, Thiago M., Verri, Waldiceu A.

“…ABSTRACT Neuropathic pain from injury to the peripheral and CNS represents a major health care issue. We have investigated the role of IL‐33/IL‐33 receptor…”
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Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection by Segueni, Noria, Vigne, Solenne, Palmer, Gaby, Bourigault, Marie-Laure, Olleros, Maria L, Vesin, Dominique, Garcia, Irene, Ryffel, Bernhard, Quesniaux, Valérie F J, Gabay, Cem

“…IL-36 cytokines are members of the IL-1 family of cytokines that stimulate dendritic cells and T cells leading to enhanced T helper 1 responses in vitro and in…”
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Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3 by Huot-Marchand, Sarah, Nascimento, Mégane, Culerier, Elodie, Bourenane, Mélissa, Savigny, Florence, Panek, Corinne, Serdjebi, Cindy, Le Bert, Marc, Quesniaux, Valérie F J, Ryffel, Bernhard, Broz, Petr, Riteau, Nicolas, Gombault, Aurélie, Couillin, Isabelle

“…Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS)…”
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Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy by Chavez-Galan, Leslie, Vesin, Dominique, Uysal, Husnu, Blaser, Guillaume, Benkhoucha, Mahdia, Ryffel, Bernhard, Quesniaux, Valérie F J, Garcia, Irene

“…Pleural tuberculosis (TB) is a form of extra-pulmonary TB observed in patients infected with . Accumulation of myeloid-derived suppressor cells (MDSC) has been…”
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Critical role of IL‐33 receptor ST2 in experimental cerebral malaria development by Palomo, Jennifer, Reverchon, Flora, Piotet, Julie, Besnard, Anne‐Gaelle, Couturier‐Maillard, Aurélie, Maillet, Isabelle, Tefit, Maurel, Erard, François, Mazier, Dominique, Ryffel, Bernhard, Quesniaux, Valérie F. J.

“…Cerebral malaria, a severe complication of Plasmodium falciparum infection, can be modeled in murine Plasmodium berghei ANKA (PbA) infection. PbA‐induced…”
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B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure by Nascimento, Mégane, Huot-Marchand, Sarah, Gombault, Aurélie, Panek, Corinne, Bourinet, Manon, Fanny, Manoussa, Savigny, Florence, Schneider, Pascal, Le Bert, Marc, Ryffel, Bernhard, Riteau, Nicolas, Quesniaux, Valérie F J, Couillin, Isabelle

“…Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary…”
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Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy by Uysal, Husnu, Chavez-Galan, Leslie, Vesin, Dominique, Blaser, Guillaume, Benkhoucha, Mahdia, Ryffel, Bernhard, Quesniaux, Valérie F J, Garcia, Irene

“…Pleural tuberculosis is one of the most frequent forms of extra-pulmonary tuberculosis observed in patients infected with Tumor Necrosis Factor (TNF) is a…”
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NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner by Nascimento, Mégane, Huot-Marchand, Sarah, Fanny, Manoussa, Straube, Marjolène, Le Bert, Marc, Savigny, Florence, Apetoh, Lionel, Van Snick, Jacques, Trovero, Fabrice, Chamaillard, Mathias, Quesniaux, Valérie F J, Ryffel, Bernhard, Gosset, Philippe, Gombault, Aurélie, Riteau, Nicolas, Sokol, Harry, Couillin, Isabelle

“…Chronic obstructive pulmonary disease (COPD) is a major health issue primarily caused by cigarette smoke (CS) and characterized by breathlessness and repeated…”
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Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection by Court, Nathalie, Vasseur, Virginie, Vacher, Rachel, Frémond, Cécile, Shebzukhov, Yury, Yeremeev, Vladimir V, Maillet, Isabelle, Nedospasov, Sergei A, Gordon, Siamon, Fallon, Padraic G, Suzuki, Hiroshi, Ryffel, Bernhard, Quesniaux, Valérie F J

“…Mycobacterium tuberculosis is recognized by multiple pattern recognition receptors involved in innate immune defense, but their direct role in tuberculosis…”
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Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection by Palomo, Jennifer, Marchiol, Tiffany, Piotet, Julie, Fauconnier, Louis, Robinet, Marieke, Reverchon, Flora, Le Bert, Marc, Togbe, Dieudonnée, Buijs-Offerman, Ruvalic, Stolarczyk, Marta, Quesniaux, Valérie F J, Scholte, Bob J, Ryffel, Bernhard

“…Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we revisited the role of IL-1β in lung pathology using the…”
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Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis by RITEAU, Nicolas, GASSE, Pamela, RYFFEL, Bernhard, COUILLIN, Isabelle, FAUCONNIER, Louis, GOMBAULT, Aurélie, COUEGNAT, Marion, FICK, Lizette, KANELLOPOULOS, Jean, QUESNIAUX, Valérie F. J, MARCHAND-ADAM, Sylvain, CRESTANI, Bruno

“…Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators released on lung injury and showed that…”
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NLRP6 negatively regulates type 2 immune responses in mice by Chenuet, Pauline, Marquant, Quentin, Fauconnier, Louis, Youness, Ali, Mellier, Manon, Marchiol, Tiffany, Rouxel, Nathalie, Messaoud‐Nacer, Yasmine, Maillet, Isabelle, Ledru, Aurélie, Quesniaux, Valérie F. J., Ryffel, Bernhard, Horsnell, William, Végran, Frédérique, Apetoh, Lionel, Togbe, Dieudonnée

“…Background Inflammasomes are large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection. Following…”
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Synthesis and Biological Investigation of PIM Mimics Carrying Biotin or a Fluorescent Label for Cellular Imaging by Front, Sophie, Bourigault, Marie-Laure, Rose, Stéphanie, Noria, Ségueni, Quesniaux, Valérie F. J, Martin, Olivier R

“…Phosphatidyl inositol mannosides (PIMs) are constituents of the mycobacterial cell wall; these glycolipids are known to exhibit potent inhibitory activity…”
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Cell iron status influences macrophage polarization by Agoro, Rafiou, Taleb, Meriem, Quesniaux, Valerie F J, Mura, Catherine

“…Macrophages play crucial roles in innate immune response and in the priming of adaptive immunity, and are characterized by their phenotypic heterogeneity and…”
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