The expanding field of IgG4-mediated neurological autoimmune disorders

The expanding field of IgG4-mediated neurological autoimmune disorders

At least 13 different disease entities affecting the central nervous system, peripheral nervous system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 (IgG4) immune reactivity. IgG4 has always been considered a benign, non‐inflammatory subclass of IgG, in contrast...

Full description

Saved in:
Bibliographic Details
Published in:European journal of neurology Vol. 22; no. 8; pp. 1151 - 1161
Main Authors: Huijbers, M. G., Querol, L. A., Niks, E. H., Plomp, J. J., van der Maarel, S. M., Graus, F., Dalmau, J., Illa, I., Verschuuren, J. J.
Format: Journal Article
Language:English
Published: England Blackwell Publishing Ltd 01-08-2015
John Wiley & Sons, Inc
Subjects:
Autoimmune Diseases of the Nervous System - immunology
autoimmunity
CIDP
Humans
IgG4
Iglon5
Immunoglobulin G - immunology
Lgi1
membranous nephropathy
MuSK myasthenia gravis
Nervous system
neurofascin
pemphigus
neurofascin
autoimmunity
pemphigus
Lgi1
MuSK myasthenia gravis
Iglon5
IgG4
CIDP
membranous nephropathy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:At least 13 different disease entities affecting the central nervous system, peripheral nervous system and connective tissue of the skin or kidneys are associated with immunoglobulin G4 (IgG4) immune reactivity. IgG4 has always been considered a benign, non‐inflammatory subclass of IgG, in contrast to the well‐known complement‐activating pro‐inflammatory IgG1 subclass. A comprehensive review of these IgG4 autoimmune disorders reveals striking similarities in epitope binding and human leukocyte antigen (HLA) associations. Mechanical interference of extracellular ligand−receptor interactions by the associated IgG4 antibodies seems to be the common/converging disease mechanism in these disorders.
Bibliography:L'Association Française contre les myopathies
Stichting Spieren voor Spieren
Prinses Beatrix Spierfonds
istex:A568AB76245D5654FCE75753226C3106B3BBD19D
ark:/67375/WNG-CN95XJFW-9
ArticleID:ENE12758
Fondo de Investigaciones Sanitarias - Instituto de Salud Carlos III - No. JR 13/00014
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.12758