Search Results - "Querfurth, HW"

Flow velocity and pulsatility of the ocular circulation in chronic intracranial hypertension by Querfurth, H. W., Lagrèze, W.-D. A., Hedges, T. R., Heggerick, P. A.

“…Objectives– The aim of this study is to examine the relationship of ocular blood flow velocities and pulsatility to intracranial pressure (ICP). Methods– We…”
Get full text

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons by Magrané, Jordi, Smith, Roy C, Walsh, Kenneth, Querfurth, Henry W

“…Intracellular beta-amyloid 42 (Abeta42) accumulation is increasingly recognized as an early event in the pathogenesis of Alzheimer's disease (AD). We have…”
Get full text

Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response by Magrané, Jordi, Rosen, Kenneth M, Smith, Roy C, Walsh, Kenneth, Gouras, Gunnar K, Querfurth, Henry W

“…Early events in Alzheimer's disease (AD) pathogenesis implicate the accumulation of beta-amyloid (Abeta) peptide inside neurons in vulnerable brain regions…”
Get full text

Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle Cells by Rosen, Kenneth M., Veereshwarayya, Vimal, Moussa, Charbel E-H., Fu, Qinghao, Goldberg, Matthew S., Schlossmacher, Michael G., Shen, Jie, Querfurth, Henry W.

“…Mutations in the ubiquitin ligase-encoding Parkin gene have been implicated in the pathogenesis of autosomal recessive Parkinson disease. Outside of the…”
Get full text

Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model by Sugarman, Michael C., Kitazawa, Masashi, Baker, Michael, Caiozzo, Vincent J., Querfurth, Henry W., LaFerla, Frank M.

“…Inclusion body myositis (IBM) is the most common age-related degenerative skeletal muscle disorder. The aberrant intracellular accumulation of the β-amyloid…”
Get full text

Calcium Dyshomeostasis in β-Amyloid and Tau-bearing Skeletal Myotubes by Christensen, Rial A., Shtifman, Alexander, Allen, Paul D., Lopez, Jose R., Querfurth, Henry W.

“…The relative scarcity of inclusion-affected muscle cells or markers of cell death in inclusion body myositis (IBM) is in distinction to the specific and early…”
Get full text

Dissociation of ERK and Akt signaling in endothelial cell angiogenic responses to β-amyloid by Magrane, Jordi, Christensen, Rial A., Rosen, Kenneth M., Veereshwarayya, Vimal, Querfurth, Henry W.

“…Cerebrovascular deposits of β-amyloid (Aβ) peptides are found in Alzheimer's disease and cerebral amyloid angiopathy with stroke or dementia. Dysregulations of…”
Get full text

Calcium Ionophore Increases Amyloid .beta. Peptide Production by Cultured Cells by Querfurth, Henry W, Selkoe, Dennis J

“…Amyloid beta peptide (A beta) is released into the media of a variety of cells in culture during normal metabolism. The discovery of several missense mutations…”
Get full text

Caffeine Stimulates Amyloid β‐Peptide Release from β‐Amyloid Precursor Protein‐Transfected HEK293 Cells by Querfurth, Henry W., Jiang, Jinwei, Geiger, Jonathan D., Selkoe, Dennis J.

“…: Extracellular amyloid β‐peptide (Aβ) deposition is a pathological feature of Alzheimer's disease and the aging brain. Intracellular Aβ accumulation is…”
Get full text

β-Amyloid Peptide Expression Is Sufficient for Myotube Death: Implications for Human Inclusion Body Myopathy by Querfurth, Henry W., Suhara, Toshimitsu, Rosen, Kenneth M., McPhie, Donna L., Fujio, Yasushi, Tejada, George, Neve, Rachael L., Adelman, Lester S., Walsh, Kenneth

“…Inclusion body myositis (sIBM) is the most common disorder of skeletal muscle in aged humans. It shares biochemical features with Alzheimer's disease,…”
Get full text

Prediction of intracranial pressure from noninvasive transocular venous and arterial hemodynamic measurements: a pilot study by Querfurth, Henry W, Arms, Steven W, Lichy, Christoph M, Irwin, William T, Steiner, Thorsten

“…Continuous measurement of intracranial pressure (ICP) requires the invasive placement of epidural, parenchymal, or intraventricular devices. For critical…”
Get full text

Downregulation and increased turnover of β-amyloid precursor protein in skeletal muscle cultures by neuregulin-1 by Rosen, Kenneth M, Ford, Byron D, Querfurth, Henry W

“…The β-amyloid precursor protein (βAPP) is found in skeletal muscle localized to the base of the postsynaptic folds of the neuromuscular junction; yet here, as…”
Get full text

Enhancer function and novel DNA binding protein activity in the near upstream βAPP gene promoter by Querfurth, H.W., Jiang, J., Xia, W., Selkoe, D.J.

“…The role of βAPP gene transcription and promoter regulation in modifying amyloid β-peptide (Aβ) levels is not well understood. Increased production of Aβ or…”
Get full text

Expression of ryanodine receptors in human embryonic kidney (HEK293) cells by Querfurth, H W, Haughey, N J, Greenway, S C, Yacono, P W, Golan, D E, Geiger, J D

“…It has been shown previously that mobilization of caffeine-sensitive intracellular calcium (Ca2+i) stores increased the release of amyloid beta-peptide (Abeta)…”
Get full text

Acetylcholinesterase inhibition in dementia with Lewy bodies: results of a prospective pilot trial by Querfurth, H W, Allam, G J, Geffroy, M A, Schiff, H B, Kaplan, R F

“…Dementia with Lewy bodies (DLB) is the second commonest form of dementia. The response to acetylcholinesterase inhibition (AChEI) could be greater in DLB than…”
Get more information

Sodium channels in normal and regenerated feline ventral spinal roots by Querfurth, HW, Armstrong, R, Herndon, RM

“…Regenerated and remyelinated nerve fibers have shorter internodes and thus more nodes than normal mature fibers. This requires either a decrease in the number…”
Get full text