Search Results - "Quentin, N"

Defining the catalytic activity of nanoceria in the P23H-1 rat, a photoreceptor degeneration model by Wong, Lily L, Pye, Quentin N, Chen, Lijuan, Seal, Sudipta, McGinnis, James F

“…Inorganic catalytic nanoceria or cerium oxide nanoparticles (CeNPs) are bona fide antioxidants that possess regenerative radical scavenging activities in…”
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Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection by Wong, Lily L, Hirst, Suzanne M, Pye, Quentin N, Reilly, Christopher M, Seal, Sudipta, McGinnis, James F

“…Cerium oxide nanoparticles (nanoceria) possess catalytic and regenerative radical scavenging activities. The ability of nanoceria to maintain cellular redox…”
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Antioxidants in central nervous system diseases: preclinical promise and translational challenges by Kamat, Chandrashekhar D, Gadal, Sunyana, Mhatre, Molina, Williamson, Kelly S, Pye, Quentin N, Hensley, Kenneth

“…Oxidative damage is strongly implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis,…”
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Greater Microbial Translocation and Vulnerability to Metabolic Disease in Healthy Aged Female Monkeys by Wilson, Quentin N., Wells, Magan, Davis, Ashley T., Sherrill, Christina, Tsilimigras, Matthew C. B., Jones, Roshonda B., Fodor, Anthony A., Kavanagh, Kylie

“…Monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (MT) and inflammation with…”
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On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis by Hensley, Kenneth, Mhatre, Molina, Mou, Shenyun, Pye, Quentin N, Stewart, Charles, West, Melinda, Williamson, Kelly S

“…The central nervous system (CNS) presents both challenges and opportunities to researchers of redox biochemistry. The CNS is sensitive to oxidative damage…”
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Epizootic Yersinia enterocolitica in captive African green monkeys ( Chlorocebus aethiops sabaeus ) by Balamayooran, Gayathriy, Atkins, Hannah M, Andrews, Rachel N, Michalson, Kristofer T, Hutchison, A Robert, LeGrande, Andre C, Wilson, Quentin N, Gee, Melaney K, Aycock, S Tyler, Jorgensen, Matthew J, Young, Richard W, Kock, Nancy D, Caudell, David L

“…is a Gram-negative bacterium that typical results in enterocolitis in humans and poses significant worldwide risks to public health. An outbreak of yersiniosis…”
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Evolutionary vs imitation learning for neuromorphic control at the edge by Schuman, Catherine, Patton, Robert, Kulkarni, Shruti, Parsa, Maryam, Stahl, Christopher, Haas, N Quentin, Mitchell, J Parker, Snyder, Shay, Nagle, Amelie, Shanafield, Alexandra, Potok, Thomas

“…Abstract Neuromorphic computing offers the opportunity to implement extremely low power artificial intelligence at the edge. Control applications, such as…”
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Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis by Hensley, Kenneth, Fedynyshyn, Joe, Ferrell, Scott, Floyd, Robert A, Gordon, Brian, Grammas, Paula, Hamdheydari, Ladan, Mhatre, Molina, Mou, Shenyun, Pye, Quentin N, Stewart, Charles, West, Melinda, West, Stuart, Williamson, Kelly S

“…Recent data indicate that certain pro-inflammatory cytokines are transcriptionally upregulated in the spinal cords of G93A-SOD1 mice, a model of amyotrophic…”
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Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis by Hensley, Kenneth, Floyd, Robert A., Gordon, Brian, Mou, Shenyun, Pye, Quentin N., Stewart, Charles, West, Melinda, Williamson, Kelly

“…Familial amyotrophic lateral sclerosis (FALS) is often caused by gain‐of‐function mutations in Cu,Zn‐superoxide dismutase (SOD1). Multiprobe ribonuclease…”
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Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation by Hensley, Kenneth, Abdel-Moaty, Haitham, Hunter, Jerrod, Mhatre, Molina, Mou, Shenyun, Nguyen, Kim, Potapova, Tamara, Pye, Quentin N, Qi, Min, Rice, Heather, Stewart, Charles, Stroukoff, Katharine, West, Melinda

“…Detailed study of glial inflammation has been hindered by lack of cell culture systems that spontaneously demonstrate the "neuroinflammatory phenotype". Mice…”
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A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECD by Williamson, Kelly S., Morris, J. Brad, Pye, Quentin N., Kamat, Chandrashekhar D., Hensley, Kenneth

“…The objective of this study was to determine the composition and content of sesamin and desmethyl tocopherols such as α‐tocopherol (αT), δ‐tocopherol (δT) and…”
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Correction: Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection by Wong, Lily L., Hirst, Suzanne M., Pye, Quentin N., Reilly, Christopher M., Seal, Sudipta, McGinnis, James F.

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Differential structure and activity between human and mouse intelectin-1: Human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer by Tsuji, Shoutaro, Yamashita, Makiko, Nishiyama, Akihito, Shinohara, Tsutomu, Li, Zhongwei, Myrvik, Quentin N, Hoffman, Donald R, Henriksen, Ruth Ann, Shibata, Yoshimi

“…Human intelectin-1 (hITLN-1) is a 120-kDa lectin recognizing galactofuranosyl residues found in cell walls of various microorganisms but not in mammalian…”
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Anti-inflammatory effects of tocopherol metabolites by Grammas, Paula, Hamdheydari, Ladan, Benaksas, Elaine J, Mou, Shenyun, Pye, Quentin N, Wechter, William J, Floyd, Robert A, Stewart, Charles, Hensley, Kenneth

“…Our objective was to assess the anti-inflammatory effects of α-tocopherol, γ-tocopherol, and their metabolites…”
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Splenic PGE2-releasing macrophages regulate Th1 and Th2 immune responses in mice treated with heat-killed BCG by Shibata, Yoshimi, Henriksen, Ruth Ann, Honda, Ikuro, Nakamura, Reiko M., Myrvik, Quentin N.

“…Hosts infected with low doses of mycobacteria develop T helper cell type 1 (Th1) immunity, but at relatively higher doses, a switch to Th2 immunity occurs…”
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Oral Administration of Chitin Down-Regulates Serum IgE Levels and Lung Eosinophilia in the Allergic Mouse by Shibata, Yoshimi, Foster, L. Ann, Bradfield, John F, Myrvik, Quentin N

“…Previous studies showed that local macrophages phagocytose nonantigenic chitin particles (1-10 micrometer polymers of N-acetyl-<cmd SC>d<cmd /SC> -glucosamine)…”
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The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice by West, Melinda, Mhatre, Molina, Ceballos, Alex, Floyd, Robert A., Grammas, Paula, Gabbita, S. Prasad, Hamdheydari, Ladan, Mai, Tammy, Mou, Shenyun, Pye, Quentin N., Stewart, Charles, West, Stuart, Williamson, Kelly S., Zemlan, Frank, Hensley, Kenneth

“…Familial forms of amyotrophic lateral sclerosis (ALS) can be caused by mutations in copper, zinc‐superoxide dismutase (SOD1). Mice expressing SOD1 mutants…”
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Inhalation of environmental stressors & chronic inflammation: Autoimmunity and neurodegeneration by Gomez-Mejiba, Sandra E., Zhai, Zili, Akram, Hammad, Pye, Quentin N., Hensley, Kenneth, Kurien, Biji T., Scofield, R. Hal, Ramirez, Dario C.

“…Human life expectancy and welfare has decreased because of the increase in environmental stressors in the air. An environmental stressor is a natural or…”
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p38 Kinase Is Activated in the Alzheimer's Disease Brain by Hensley, Kenneth, Floyd, Robert A., Zheng, Nai‐Ying, Nael, Raha, Robinson, Kent A., Nguyen, Xuan, Pye, Quentin N., Stewart, Charles A., Geddes, James, Markesbery, William R., Patel, Ela, Johnson, Gail V. W., Bing, Guoying

“…: The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the…”
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Persistent Inactivation of Macrophage Cyclooxygenase-2 in Mycobacterial Pulmonary Inflammation by Shinohara, Tsutomu, Pantuso, Traci, Shinohara, Shizuka, Kogiso, Mari, Myrvik, Quentin N, Henriksen, Ruth Ann, Shibata, Yoshimi

“…The induction of cyclooxygenase-2 (COX-2) in tissue macrophages (MØ) increases prostaglandin E(2) (PGE(2)) release, potentially down-regulating granulomatous…”
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